Also known as: IVIG
A 19-month-old girl with influenza A (H1N1)-associated acute necrotizing encephalitis made a complete neurological recovery despite a severity score of 6. Multimodal immunomodulatory therapy including IVIG, corticosteroids, anakinra, and plasma exchange led to rapid decline in blood cytokine levels. The case underscores early recognition and targeted treatment in young children.
Three FcRn inhibitors are approved for generalized myasthenia gravis, with a head-to-head trial of efgartigimod and nipocalimab underway. Emerging therapies including telitacicept, gefurulimab, and CAR-T cell therapy (KYV-101) show promise, while Immunovant's batoclimab failed TED trials.
The FDA has accepted Hansa Biopharma's Biologics License Application for imlifidase, a desensitization treatment for highly sensitized adult kidney transplant patients with positive crossmatch against deceased donors, with a PDUFA date of December 19, 2026.
CAR T-cell therapy is delivering high remission rates for multiple myeloma patients, with improved handoff communication reducing infection risks. FDA-approved BCMA-targeting products show response rates from 72% to 98% in heavily pretreated patients.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07698080 |
Dexamethasone, Intravenous Injection of Human Immunoglobulin, and Increased Infusion of Mononuclear Cells to Reduce Donor Specific Antibodies in Haploidentical Hematopoietic Stem Cell Transplantation |
NOT_YET_RECRUITING | PHASE2 |
| NCT07674745 |
Autoantibody Reduction Therapy for Progressive Idiopathic Pulmonary Fibrosis |
NOT_YET_RECRUITING | PHASE2 |
| NCT07561125 |
Effects of IVIG for BPD in Preterm Infant Born at 28 Weeks and Below |
RECRUITING | PHASE2 |
| NCT07202052 |
Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Platform Trial (RATIONAL-PT) |
RECRUITING | PHASE2/PHASE3 |
| NCT06925360 |
IVIG Trial for the Treatment of Bronchopulmonary Dysplasia |
RECRUITING | PHASE2 |
| NCT06183008 |
IVIG in Painful Sensory Neuropathy |
NOT_YET_RECRUITING | PHASE4 |
| NCT05634824 |
IVIg Plus Low Dose rhTPO for ITP in Pregnancy |
UNKNOWN | PHASE2 |
| NCT05604859 |
Evaluate the Efficacy and Safety of Various Treatment Schemes for Severe Fever With Thrombocytopenia Syndrome(SFTS) |
UNKNOWN | PHASE4 |
| NCT05520892 |
Two Regimens of IVIG in the Treatment of Newly Diagnosed ITP in Children |
RECRUITING | PHASE4 |
| NCT05134792 |
Effect of Pre-emptive Intravenous Immunoglobulin (IVIG) on the Incidence of Septic Episodes in Pediatric Burn Patients |
COMPLETED | PHASE2/PHASE3 |
