Emtricitabine is a nucleoside reverse-transcriptase inhibitor (NRTI) antiretroviral used for prevention and treatment of HIV-1 infection, usually in combination regimens. It is marketed as Emtriva and is also included in widely used fixed-dose combinations such as Truvada and Descovy. It is an oral prescription medicine.
Merck announced Phase 3 trial results for its investigational once-daily, two-drug HIV regimen doravirine/islatravir at CROI 2026, demonstrating non-inferiority to standard treatment in treatment-naïve adults with viral suppression rates of 91.8% at Week 48.
A once-daily single-tablet combination of bictegravir and lenacapavir demonstrated non-inferiority to existing HIV treatments in Phase 3 trials, offering simplified treatment for people living with HIV who are virologically suppressed.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT05979311 |
A Study to Evaluate the Efficacy, Safety, and Tolerability of Using an Oral Once-daily 2 Drug Regimen Compared to an Oral Once-daily 3 Drug Regimen for the Treatment of Human Immunodeficiency Virus (HIV)-1 in Adults Who Have Not Previously Taken Antiretroviral Therapy |
ACTIVE_NOT_RECRUITING | PHASE3 |
| NCT04862975 |
Pharmacokinetics of Antiretroviral Drugs in Lactating Women and Breastmilk Fed Infants Under 6 Months of Age in Botswana |
COMPLETED | |
| NCT04477096 |
Evaluation of Drug Interaction Between HS-10234 and Emtriccitabine |
COMPLETED | PHASE1 |
| NCT03218085 |
Role of Exogenous and Endogenous Sex Hormones on Tenofovir and Emtricitabine Disposition in Female Genital Tract |
COMPLETED | |
| NCT02904369 |
PK and PD Study of Oral F/TAF for HIV Prevention |
COMPLETED | PHASE1 |
| NCT02475915 |
Efficacy of VHM After Treatment Interruption in Subjects Initiating ART During Acute HIV Infection |
COMPLETED | PHASE1/PHASE2 |
| NCT02327715 |
Emtricitabine for Prevention of Vertical Transmission of HBV in Chinese Pregnant HBsAg Positive Patients |
UNKNOWN | PHASE4 |
| NCT02327702 |
Emtricitabine for Naive Chinese Pregnant Chronic Hepatitis B Patients |
UNKNOWN | PHASE4 |
| NCT02327676 |
Emtricitabine for Naive Child Chinese Chronic Hepatitis B Patients |
UNKNOWN | PHASE4 |
| NCT02327663 |
Emtricitabine for Naive Chinese Chronic Hepatitis B Patients |
UNKNOWN | PHASE4 |
