CS2009

Drug

Drug Profile

CS2009 is an investigational PD-1/VEGFA/CTLA-4 trispecific antibody developed by CStone for solid tumors. Clinical development has progressed through Phase I/II with more than 200 enrolled patients and ongoing preparation for Phase III multi-regional studies. The agent remains unapproved and in clinical development.

Drug Class
Trispecific antibody targeting PD-1, VEGFA, and CTLA-4
Approval Status
Investigational; IND-cleared with ongoing Phase I/II and planned Phase III trials, but not approved for marketing
Mechanism of Action
Combines anti-PD-1, anti-CTLA-4, and anti-VEGFA activities to reverse T-cell exhaustion, promote T-cell activation, inhibit angiogenesis, and remodel the tumor microenvironment
Indications
  • \Advanced solid tumors (investigational)\
  • \Non-small cell lung cancer (investigational)\
  • \Colorectal cancer (investigational)\

Related News

Related Clinical Trials

NCT ID Title Status Phase
NCT06741644

A Phase I/II Study of CS2009 in Participants With Advanced Solid Tumors

RECRUITING PHASE1/PHASE2