Colistin (polymyxin E) is a polymyxin-class antibiotic mainly reserved for severe multidrug-resistant Gram-negative infections. It is used in different formulations including intravenous colistimethate sodium and topical/oral colistin sulfate. The drug is prescription-only in major markets.
BioVersys AG received FDA approval to enroll U.S. patients in a global Phase 3 trial evaluating BV100 for hospital-acquired pneumonia caused by carbapenem-resistant Acinetobacter baumannii, with trial completion expected by end of 2027.
CDC and FDA are investigating a multistate outbreak of extensively drug-resistant Salmonella Newport infections linked to Rosabella brand moringa powder capsules, with seven people sickened across seven states and three requiring hospitalization.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07326540 |
Efficacy and Safety of BV100 Plus Low Dose Polymyxin B Versus Colistin Plus High-dose Ampicillin/Sulbactam in Patients With Hospital-acquired or Ventilator-associated Bacterial Pneumonia Due to Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex |
RECRUITING | PHASE3 |
| NCT06827756 |
Comparative Study of Secondary Prophylaxis for SBP |
COMPLETED | PHASE4 |
| NCT05922124 |
Cefiderocol and Ampicillin-sulbactam vs. Colistin +/- Meropenem for Carbapenem Resistant A. Baumannii |
RECRUITING | PHASE4 |
| NCT05689229 |
Aerosolized Versus Intravenous Colistin-based Antimicrobial Regimens in Hospitalized COVID-19 Patients With Bacterial Coinfection: A Randomized Controlled Trial |
COMPLETED | PHASE3 |
| NCT05613361 |
The Effect of Curcumin Against Colistin-induced Nephrotoxicity |
RECRUITING | PHASE3 |
| NCT05586815 |
Efficacy of Colistin Monotherapy Versus Colistin Plus Minocycline for Carbapenem-Resistant A. Baumannii Infection |
UNKNOWN | PHASE4 |
| NCT05542446 |
Pharmacokinetics of Colistin in Critically Ill Patients With Extracorporeal Membrane Oxygenation |
TERMINATED | PHASE4 |
| NCT05279586 |
Secondary Prophylaxis of Hepatic Encephalopathy in Cirrhotic Patients |
UNKNOWN | EARLY_PHASE1 |
| NCT05258851 |
Ceftazidime-Avibactam Use in Critically Ill Patients With Carbapenem-Resistant Enterobacteriaceae Infections |
TERMINATED | PHASE3 |
| NCT04995133 |
Colistin Intravenous Administration in Critically Ill Patients Suffering From Hospital Infections Caused by Multi-antibiotic-resistant Germs. |
UNKNOWN | PHASE4 |
