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NCT06413706 A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy Status ACTIVE_NOT_RECRUITING Phase PHASE2
NCT06409390 Sequential Therapies Modeled on Evolutionary Dynamics for Breast Cancer Status RECRUITING Phase PHASE2
NCT06380751 Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer Status RECRUITING Phase PHASE3
NCT06365788 Bicalutamide and Abemaciclib in Inoperable or Metastatic Androgen Receptor-positive Triple-negative Breast Cancer Status RECRUITING Phase PHASE2
NCT06188520 A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors Status RECRUITING Phase PHASE1/PHASE2
NCT06179303 Functional Imaging in Prediction of Response to Abemaciclib for Advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer Status RECRUITING Phase PHASE2
NCT06169371 Abemaciclib Dose Escalation to Maintain Intensity (ADE-MI) Status RECRUITING Phase PHASE4
NCT06065748 A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer) Status RECRUITING Phase PHASE3
NCT06025747 Evaluation of Abemaciclib and Radiation Therapy Before Surgery for the Treatment of High-Risk Adipocytic Retroperitoneal Sarcoma Status RECRUITING Phase PHASE1
NCT06001762 TRADE: Dose Escalation Tolerability of Abemaciclib in HR+ HER2- Early Stage Breast Cancer Status ACTIVE_NOT_RECRUITING Phase PHASE2
NCT05999994 A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer Status RECRUITING Phase PHASE2
NCT05999968 Abemaciclib Plus Darolutamide in Prostate Cancer That Has Spread After Initial Treatment Status COMPLETED Phase PHASE1
NCT05952557 An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2) Status RECRUITING Phase PHASE3
NCT05933395 Genetically-informed Therapy for ER+ Breast Cancer Post-CDK4/6 Inhibitor Status RECRUITING Phase PHASE2
NCT05891093 Efficacy and Safety of Fluzoparib Combined With Adjuvant Endocrine Therapy for HR+/HER2- SNF3-subtype Early Breast Cancer (BCTOP-L-A01) Status RECRUITING Phase PHASE3
NCT05872204 Abemaciclib and Letrozole in Patients With Estrogen Receptor-positive Rare Ovarian Cancer Status RECRUITING Phase PHASE2