A newly reported antimicrobial peptide, GT-2, selectively disrupts microbial membranes while sparing mammalian cells. The peptide adopts a helical conformation in response to bacterial and fungal lipids and reduced Pseudomonas aeruginosa wound burden below the detection limit in a topical model.
Researchers at McMaster University said their SyntheMol-RL AI model designed a new antibiotic candidate called synthecin. In mouse wound infection models, the topical compound was highly effective against drug-resistant Staphylococcus aureus.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT06025253 |
PINTA - Prophylactic Incisional Negative Pressure Therapy for Major Amputations |
RECRUITING | NA |
| NCT05977816 |
PROPEL-2: Prophylactic Negative Pressure Wound Therapy in Laparotomy Wounds |
ACTIVE_NOT_RECRUITING | NA |
| NCT05196880 |
Biofilm Correlation and Validation |
COMPLETED |
