Mavacamten significantly reduces heart obstruction in adolescents with hypertrophic cardiomyopathy, with patients experiencing a 48.5 mm Hg drop in blockage compared to minimal change in placebo groups. The drug also lowered blood markers indicating heart damage and showed promise in slowing disease progression. Separate real-world data confirms mavacamten's effectiveness as monotherapy across diverse patient populations.
Novartis announced positive European regulatory opinion for remibrutinib in chronic spontaneous urticaria and reported the drug met its primary endpoint in a Phase 3 trial for chronic inducible urticaria.
Novartis announced positive Phase III RemIND trial results for oral remibrutinib in chronic inducible urticaria, marking the first therapy to meet a Phase III primary endpoint in the condition. The company has submitted a supplemental New Drug Application to the FDA.
International researchers have identified a specific antibody mutation that causes rare but serious blood clots after adenovirus-based COVID-19 vaccines or natural adenovirus infection, providing a roadmap for safer vaccine design.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07327762 |
Comparison of Two Different Suture Knot Techniques on Post-Operative Trismus and Swelling After Impacted Third Molar Surgery |
NOT_YET_RECRUITING | NA |
| NCT07196904 |
Ultrasonic vs Rotary Instruments in Impacted Mandibular Third Molar Surgery: Clinical and Salivary CRP Outcomes |
COMPLETED | NA |
| NCT06967246 |
Effect of Kinesio Taping of Pain, Swelling and Trismus After Mandibular Third Molar Surgery |
COMPLETED | NA |
| NCT06293209 |
Effect of Cool Spray and Cold Packs in Reducing Preoperative Edema and Pain in Ankle Fractures in Ubonratchathani |
ACTIVE_NOT_RECRUITING | NA |
| NCT03672669 |
Comparison of the Effect of A-PRF and L-PRF on Outcomes After Removal of Impacted Mandibular Third Molar |
COMPLETED | NA |
| NCT03492814 |
Comparing Different Suturing Techniques on the Post-operative Morbidity After Removal of Impacted Mandibular Third Molar |
COMPLETED | NA |
| NCT02493179 |
Efficacy Evaluation of the (Serodase 5 mg Tablet) in the Treatment of Inflammation After Third Molar Surgery |
UNKNOWN | PHASE4 |
| NCT01551017 |
Fast Track Recovery Knee Arthroplasty Project |
UNKNOWN | |
| NCT01431014 |
Effect of Steroid for the Postoperative Swelling After Orthognathic Surgery |
COMPLETED | PHASE4 |
| NCT01371877 |
The Role of Vitamin D in Chronic Urticaria and Angioedema Treatment |
COMPLETED | NA |
