Spinal cord injury is damage to the spinal cord that disrupts motor, sensory, and autonomic function below the injury level. Severity ranges from incomplete to complete injury and can cause long-term disability.
The FDA cleared neuromodulation devices from Epineuron, Aneuvo and Encora Therapeutics. The products address peripheral nerve surgery, spinal cord injury neurorehabilitation and essential tremor.
A preclinical study in Precision Clinical Medicine found that luteolin and astragaloside IV improved recovery after severe spinal cord injury in cell and rat models. The combined treatment reduced oxidative stress and neuroinflammation and improved motor function over five weeks.
AbbVie updated its completed Phase 2 elezanumab study in acute traumatic cervical spinal cord injury. The placebo-controlled trial began in March 2020 and its latest public update was posted on February 9, 2026.
Scientists at Northwestern University developed human spinal cord organoids that accurately replicate injury responses including cell death, inflammation, and glial scarring. Testing showed a "dancing molecules" therapy significantly reduced scarring and promoted nerve regrowth.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07603752 |
Implantable Wireless Brain-Machine Interface System for Spinal Cord Injury: Efficacy and Safety Study |
RECRUITING | NA |
| NCT07596563 |
Olfactory Cell Transplantation and Intensive Rehabilitation to Repair Chronic Spinal Cord Injury |
NOT_YET_RECRUITING | PHASE1 |
| NCT07594574 |
Posterior Minimally Invasive Surgery for Treating Paralytic Scoliosis With Pelvic Obliquity in Children Following Spinal Cord Injury |
ACTIVE_NOT_RECRUITING | NA |
| NCT07588711 |
Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Neuropathic Pain Following Spinal Cord Injury |
NOT_YET_RECRUITING | NA |
| NCT07588503 |
FES Cycling With BFR in the Spinal Cord Injury Population |
RECRUITING | PHASE1 |
| NCT07583576 |
Effects of Functional Electrical Stimulation on Spasticity, Quadriceps Muscle Strength and Functional Mobility in Individuals With Paraplegia |
NOT_YET_RECRUITING | NA |
| NCT07550699 |
Clinical Investigation to Validate the Safety and Performance of Integrating Functional Electrical Stimulation Into the ABLE Exoskeleton |
RECRUITING | NA |
| NCT07541612 |
NIRS MONITORING OF SPINAL CORD ISCHEMIA IN AORTIC SURGERY |
RECRUITING | |
| NCT07507331 |
Turkish Version of the Neurogenic Bladder Symptom Score Short Form |
NOT_YET_RECRUITING | |
| NCT07504055 |
Non-invasive Spinal Cord Stimulation and Blood Pressure Regulation After Spinal Cord Injury |
RECRUITING | NA |
