Spinal cord injury is damage to the spinal cord that disrupts motor, sensory, and autonomic function below the injury level. Severity ranges from incomplete to complete injury and can cause long-term disability.
FDA approved a subcutaneous starting dose of Leqembi for early Alzheimer's disease. AAIC 2026 real-world data showed most patients stable or improved; a mouse study found KCL-286 repaired DNA damage and reduced inflammation.
A Cochrane review finds exercise for hip osteoarthritis reduces pain by 7 points on a 100-point scale, below the 12-point threshold for noticeable benefit. A survey shows 76% of physical therapy patients skip home exercises, citing forgetfulness and time constraints. A study reports only 22% of stroke and brain injury survivors receive intensive inpatient rehab, with disparities by race, insurance, and income.
The FDA cleared neuromodulation devices from Epineuron, Aneuvo and Encora Therapeutics. The products address peripheral nerve surgery, spinal cord injury neurorehabilitation and essential tremor.
A preclinical study in Precision Clinical Medicine found that luteolin and astragaloside IV improved recovery after severe spinal cord injury in cell and rat models. The combined treatment reduced oxidative stress and neuroinflammation and improved motor function over five weeks.
AbbVie updated its completed Phase 2 elezanumab study in acute traumatic cervical spinal cord injury. The placebo-controlled trial began in March 2020 and its latest public update was posted on February 9, 2026.
Scientists at Northwestern University developed human spinal cord organoids that accurately replicate injury responses including cell death, inflammation, and glial scarring. Testing showed a "dancing molecules" therapy significantly reduced scarring and promoted nerve regrowth.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07768930 |
BCI-Guided Tibialis Anterior FES for Gait Training in Spinal Cord Injury |
ACTIVE_NOT_RECRUITING | NA |
| NCT07745686 |
VALSE: Integration of Neuromodulation and Exoskeleton Systems for Mobility in Individuals With Chronic Spinal Cord Injury |
NOT_YET_RECRUITING | NA |
| NCT07742553 |
Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial |
NOT_YET_RECRUITING | PHASE2/PHASE3 |
| NCT07739134 |
Multimodal Tracking of Therapy Activity and Effort During Rehabilitation |
ACTIVE_NOT_RECRUITING | |
| NCT07739043 |
NeuroRise: Intrathecal CE-1 Treatment for Traumatic SCI |
NOT_YET_RECRUITING | EARLY_PHASE1 |
| NCT07738978 |
Understanding and Enhancing Human Health and Movement |
RECRUITING | NA |
| NCT07733401 |
Guided Laminectomy With Augmented Duroplasty for Acute Traumatic Spinal Cord Injury |
NOT_YET_RECRUITING | NA |
| NCT07732868 |
Effects of a Virtual Reality-based Brain-Machine Interface Protocol in Spinal Cord Injury |
ENROLLING_BY_INVITATION | NA |
| NCT07725952 |
Cardiovascular Autonomic Function After Resistance Training |
NOT_YET_RECRUITING | NA |
| NCT07720882 |
A Clinical Study of a Fully Implanted, Wireless and Functional BCI for Upper-Limb Functional Replacement in Tetraplegia Due to Spinal Cord Injury: Efficacy and Safety |
RECRUITING | NA |
