RA stands for rheumatoid arthritis, a chronic systemic autoimmune inflammatory disease primarily affecting synovial joints and causing pain, stiffness, swelling, and progressive joint damage.
AbbVie reported positive Phase 3 data for Skyrizi's subcutaneous Crohn's disease treatment and is advancing lutikizumab and Rinvoq in hidradenitis suppurativa, with multiple readouts expected throughout 2026 as the company pursues combination therapy strategies.
Diacerein, an anthraquinone derivative, shows promise as a disease-modifying agent in rheumatoid arthritis through its anti-inflammatory and chondroprotective actions, with combination therapy appearing to enhance therapeutic benefits.
The FDA has accepted Dr. Reddy's Laboratories' BLA for DRL_AB, a proposed interchangeable biosimilar to abatacept, submitted in December 2025. The application is the first for an abatacept biosimilar and is supported by Phase 1 data showing pharmacokinetic similarity.
Scientists at Northwell Health's Feinstein Institutes have developed a novel drug discovery strategy transforming a detrimental immune element into a therapeutic for sepsis and rheumatoid arthritis, published in Military Medical Research.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07147959 |
PET-Based Imaging of Radiolabeled CIT-013 |
RECRUITING | PHASE2 |
| NCT04311567 |
Effects of Tofacitinib vs Methotrexate on Rheumatoid Arthritis Interstitial Lung Disease |
TERMINATED | PHASE4 |
| NCT04224194 |
Auto-injector Real Life Handling in Patients |
COMPLETED | PHASE3 |
| NCT02240888 |
Vaccination in Inflammatory Rheumatic Disease (VACCIMIL). The Impact of Antirheumatic Treatment on Antibody Response |
COMPLETED | NA |
| NCT02240732 |
Surgical Tourniquets and Cerebral Emboli |
COMPLETED | |
| NCT02057250 |
To Evaluate Sarilumab - SAR153191 (REGN88) - Auto-injector Device In Patients With Rheumatoid Arthritis |
COMPLETED | PHASE3 |
