Presbyopia is an age-related loss of near focusing ability due to reduced lens elasticity, causing progressive difficulty with near tasks such as reading.
FDA clears Cloudbreak Pharma's IND for CBT-199, a novel presbyopia eye drop, allowing Phase 2 trials to proceed. The company also advances CBT-001 (Phase 3 for pterygium) and CBT-004 (Phase 3 for pinguecula).
LENZ Therapeutics submitted a UK marketing authorization application for VIZZ for presbyopia on April 20, 2026. The filing follows FDA approval in July 2025 and EMA validation in March 2026.
Opus Genetics reported positive early data from its BEST1 gene therapy program and expects FDA action on its presbyopia treatment in October 2026. Ultragenyx announced 2025 revenue of $673 million and initiated a strategic restructuring plan targeting profitability in 2027.
The FDA accepted Viatris' application for phentolamine ophthalmic solution 0.75% to treat presbyopia, with a decision expected October 2026. Separately, the agency approved Yuvezzi, a once-daily combination eye drop for age-related near vision loss.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07723716 |
Evaluate the Efficacy and Safety of CTO0307 in Adults With Presbyopia |
COMPLETED | PHASE3 |
| NCT07638943 |
Refitting Satisfied INFUSE One-Day Multifocal Wearers to DAILIES TOTAL1 Multifocal Contact Lenses |
RECRUITING | NA |
| NCT07637500 |
Refocus VisAbility™ Micro Insert System Pre-market Clinical Trial |
RECRUITING | NA |
| NCT07623720 |
CorVision® 4-year Follow-up |
COMPLETED | |
| NCT07617090 |
Volumetric Visual Fields at Intermediate and Near Distances in Presbyopic Patients Using Occupational and General-Purpose Progressive Addition Lenses |
ACTIVE_NOT_RECRUITING | NA |
| NCT07600645 |
Contact Lens Trial Fitting Experience |
NOT_YET_RECRUITING | NA |
| NCT07586982 |
Clinical Performance of Verofilcon A Toric Contact Lenses |
RECRUITING | NA |
| NCT07570602 |
VisionApp - Refraction and Presbyopia |
COMPLETED | NA |
| NCT07559188 |
Proof-of-Concept for a Novel Optical Aperture Contact Lens in Presbyopia and Keratoconus |
NOT_YET_RECRUITING | NA |
| NCT07512089 |
Comparison of PRESBYOND Laser Blended Vision and Conventional Monovision LASIK in Individuals With Presbyopia: A Randomized Clinical Study |
RECRUITING | NA |
