Research reveals how ectopic NMDA receptor expression in triple-negative breast cancer triggers autoimmune disease through antibody maturation. The study shows NMDAR expression recruits B cells and drives affinity maturation, producing antibodies that can cross the blood-brain barrier and cause neurological symptoms while constraining tumor growth.
Grail's NHS-Galleri trial of 142,000 participants failed to achieve statistically significant reduction in late-stage cancer diagnoses, though secondary endpoints showed four-fold improvement in overall cancer detection rate. Stock fell 48% following the announcement.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT06784674 |
Maternal Abdominal Morphology Assessment |
RECRUITING | |
| NCT06487312 |
Clinical Trial to Evaluate the Effectiveness and Safety of a Remote Automated Ultrasound Diagnostic System for Automated Ultrasound Examinations: a Prospective, Multicenter Study |
ENROLLING_BY_INVITATION | |
| NCT04935216 |
Predictors of Postoperative Complications and Readmissions in Laparoscopic Pancreas Resection |
COMPLETED | |
| NCT04764396 |
Assessing Effects of Heparin Priming and Pass Number on Tissue Quality of Fine Needle Biopsies |
TERMINATED | NA |
| NCT03348319 |
Is There a Pancreatic Segmentation Based on the Pancreatic Duct Branching? |
WITHDRAWN | |
| NCT02979483 |
Management of Symptomatic Advanced Pancreatic Adenocarcinoma |
ACTIVE_NOT_RECRUITING | NA |
| NCT02244164 |
Pathophysiological Study of the Increase in Pancreatic Volume in Type 2 Diabetes Treatments. |
TERMINATED | NA |
| NCT01786850 |
Magnetic Resonance-guided High-intensity Focused Ultrasound Treatment of Locally Advanced Pancreatic Cancer |
AVAILABLE | |
| NCT01169649 |
Study of MK-2206 in Patients With Metastatic Neuroendocrine Tumors (NET) |
COMPLETED | PHASE2 |
| NCT00936104 |
Side Population in Pancreatic Ductal Adenocarcinoma (PDAC) |
COMPLETED |
