Ectopic NMDAR Expression in Cancer Triggers Autoimmunity Through Antibody Maturation
Mar 26, 2026
Research reveals how ectopic NMDA receptor expression in triple-negative breast cancer triggers autoimmune disease through antibody maturation. The study shows NMDAR expression recruits B cells and drives affinity maturation, producing antibodies that can cross the blood-brain barrier and cause neurological symptoms while constraining tumor growth.