Cancer care is being transformed by targeted therapy, immunotherapy, personalized medicine, and emerging mRNA-based universal cancer vaccines. Advances in immunotherapeutics and cellular therapies are improving survival rates, while an off-the-shelf mRNA vaccine from the University of Florida is already in human trials.
Two recent clinical trials found that adding immunotherapy to standard chemoradiation did not improve survival for patients with limited-stage small-cell lung cancer or high-risk HPV-positive oropharyngeal cancer, though both studies revealed important insights about treatment delivery and radiation scheduling.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07418034 |
A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED) |
NOT_YET_RECRUITING | PHASE2 |
| NCT06445114 |
Using CircuLating Tumor DNA to Risk Adapt Post-Operative Therapy for HPV-associated Oropharyngeal Cancer |
RECRUITING | PHASE2 |
| NCT05451004 |
SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer |
RECRUITING | PHASE3 |
| NCT04708470 |
A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers |
ACTIVE_NOT_RECRUITING | PHASE1/PHASE2 |
| NCT04432597 |
HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated Cancers |
COMPLETED | PHASE1/PHASE2 |
| NCT04287868 |
Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies |
COMPLETED | PHASE1/PHASE2 |
| NCT03729518 |
TORS De-Intensification Protocol Version 2.0: Dose and Volume Reduction in the Neck |
COMPLETED | NA |
| NCT03224000 |
Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer |
ACTIVE_NOT_RECRUITING | PHASE2 |
| NCT02012699 |
Integrated Cancer Repository for Cancer Research |
RECRUITING |
