Opioid addiction, clinically termed opioid use disorder (OUD), is a chronic relapsing substance use disorder characterized by compulsive opioid use despite harmful consequences. It is associated with overdose risk and major health and social burden.
Trump signed an executive order to speed FDA review of ibogaine and other psychedelic drugs and said the U.S. would dedicate $50 million to ibogaine research. The FDA is also preparing priority vouchers and steps toward the first U.S. human trials, while ibogaine remains linked to serious heart risks.
Salem city councilors are considering spending $250,000 in opioid settlement funds for a new drug treatment and recovery program at Redwood Crossings supportive housing. The proposal comes as the city launches a broader "Prevent, Treat, and Enforce" initiative to address substance abuse through treatment, prevention, and law enforcement coordination.
NIH funded dramatically fewer research grants in 2025, with funding rates dropping from 27% to 20% for established investigators and from 26% to 19% for early-career researchers, according to newly released agency data.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07022782 |
MEDiterranean Diet-driven Detoxification of OPioid Addicted patiEnts (MED-DOPE) |
ACTIVE_NOT_RECRUITING | NA |
| NCT05611749 |
Duloxetine Impact on Postoperative Pain Control and Outcomes |
TERMINATED | PHASE2 |
| NCT05299515 |
Peer Activate: Trial of Peer-Delivered Behavioral Activation for Methadone Adherence |
COMPLETED | NA |
| NCT04336293 |
sTMS for Substance Use-disordered Veterans |
COMPLETED | NA |
| NCT04325659 |
An Innovative Intervention for OUD Treatment |
COMPLETED | PHASE2/PHASE3 |
| NCT04309565 |
Transitions Clinic Network: Post Incarceration Addiction Treatment, Healthcare, and Social Support |
COMPLETED | NA |
| NCT04239235 |
Integrating Support Persons Into Recovery |
COMPLETED | NA |
| NCT03685162 |
Observational Study to Evaluate Levomethadone Safety and Effectiveness in Subjects Under Opioid Maintenance Treatment |
COMPLETED | |
| NCT03394911 |
Healthy Adult Male Facial Skin Surface Lipid Pheromone p.o. to Treat Opioid Addiction |
UNKNOWN | PHASE3 |
| NCT02897414 |
ER/LA Opioid Analgesics - Surveillance Monitoring of State Medical Examiner Databases |
UNKNOWN |
