The CONDOR randomized clinical trial found brolucizumab better preserved visual acuity than panretinal photocoagulation in proliferative diabetic retinopathy at week 54. Brolucizumab also reduced vision-threatening complications and center-involved diabetic macular edema events, while showing more intraocular inflammation.
Ocular Therapeutix announced positive topline results from the SOL-1 Phase 3 superiority trial of AXPAXLI for wet age-related macular degeneration, meeting its primary endpoint with statistically significant improvements in vision outcomes compared to aflibercept.
Ocular Therapeutix announced positive topline results from SOL-1, its Phase 3 superiority trial of AXPAXLI for wet age-related macular degeneration, meeting primary and durability endpoints with high statistical significance.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07259928 |
Safety and Proof of Concept Study of ANXV (Annexin A5) in Patients With Diabetic Retinopathy or Retinal Vein Occlusion |
RECRUITING | PHASE2 |
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A Study to Evaluate the Efficacy and Safety of OTX-TKI (Axitinib Implant) in Participants With Non-Proliferative Diabetic Retinopathy |
RECRUITING | PHASE3 |
| NCT07230184 |
To Evaluate the Efficacy and Safety of Combination Therapy With B55R1 and B55R2 Compared to B55R1 Monotherapy in Patients With NPDR |
COMPLETED | PHASE4 |
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Intravitreal and Intracameral DEX in NPDR |
ENROLLING_BY_INVITATION | PHASE3 |
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Clinical Study on the Efficacy and Safety of TNTL in the Treatment of Non-proliferative Diabetic Retinopathy |
RECRUITING | PHASE3 |
| NCT06713720 |
Remote Ischemic Conditioning for Non-Proliferative Diabetic Retinopathy |
RECRUITING | NA |
| NCT06487845 |
A Study to Learn How Safe BAY3283142 is When Taken as a Single Dose or as Multiple Doses in Healthy Chinese Participants |
COMPLETED | PHASE1 |
| NCT05695417 |
Study to Evaluate the Safety, Tolerability, and Efficacy of OTX-TKI in Subjects With Moderately Severe to Severe Non-proliferative Diabetic Retinopathy |
ACTIVE_NOT_RECRUITING | PHASE1 |
| NCT05681884 |
Safety and Efficacy of Faricimab in Patients With NPDR |
COMPLETED | PHASE2 |
| NCT05393284 |
Phase 2 Spectra Study to Evaluate the Safety and Efficacy of OPL-0401 in Patients With Diabetic Retinopathy |
ACTIVE_NOT_RECRUITING | PHASE2 |
