Drug repurposing expands the therapeutic applications of existing medications, while repositioning examines drugs that never reached market. In neurodegeneration, the approach is described as a pragmatic shortcut into mid- to late-stage trials.
Scientists at NTU Singapore developed an AI-powered biochip that detects multiple microRNA biomarkers in 20 minutes. The platform achieved more than 99 per cent accuracy in test channels.
Genomic technologies including whole-genome sequencing and polygenic risk scores are advancing precision medicine for neurodegenerative diseases like Alzheimer's and Parkinson's. Research reveals complex gene interactions in conditions like PTEN hamartoma tumor syndrome and sex-specific metabolic signatures in Alzheimer's disease. The integration of genomics with molecular neurobiology offers potential for more accurate diagnosis and treatment.
Brainstorm Cell Therapeutics announced a $1 million private placement at a premium to market price to support its upcoming Phase IIIb trial of NurOwn stem cell therapy for amyotrophic lateral sclerosis.
Recent reviews highlight expanding clinical benefits of GLP-1-based therapies, including antiinflammatory actions across multiple organs and cardiovascular risk reduction, with combination approaches emerging for obesity treatment.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
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Exploratory Clinical Study and Validation of Blood Biomarkers for Alzheimer's Disease |
COMPLETED | |
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Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance |
RECRUITING | NA |
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Optimization of Adaptive Rowing Seating |
NOT_YET_RECRUITING | NA |
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Elemental 028 Extra Case Studies |
RECRUITING | NA |
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An Innovative Method in SAliva Samples for the Early Differential Diagnosis of High-impact NeuroDegenerative Diseases Through Raman Spectroscopy |
ENROLLING_BY_INVITATION | |
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A Registered Cohort Study on Color Discrimination Deficit Associated With Neurodegenerative Disorders. |
UNKNOWN | |
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Joint Consultation Between a Neurologist and a Clinical Psychologist |
UNKNOWN | |
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Tau PET Imaging With 18F-T807(AV1451) in Neurodegenerative Disorders |
UNKNOWN | EARLY_PHASE1 |
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Mesenchymal Stem Cells for the Treatment of Various Chronic and Acute Conditions |
RECRUITING | PHASE1/PHASE2 |
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COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE |
COMPLETED |
