News Related to MC4R Deficiency

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GLP-1 Drugs Effective in Rare Genetic Obesity, Mouse Study Shows

Mar 01, 2026

Three GLP-1 weight-loss drugs—semaglutide, tirzepatide and retatrutide—reduced weight and improved metabolic health in mice lacking the MC4R gene, offering potential treatment for rare genetic obesity.

Triple-Agonist Obesity Drugs Show Weight Loss Comparable to Bariatric Surgery in Phase 3 Trials

Feb 24, 2026

Triple-agonist drug retatrutide has demonstrated weight loss outcomes similar to bariatric surgery in Phase 3 trials. Research shows GLP-1 drugs work through brain-mediated appetite suppression and are effective even in genetic obesity.