Listeriosis is a foodborne bacterial infection caused by Listeria monocytogenes that can present with invasive disease such as sepsis or meningitis, especially in high-risk populations. Severe outcomes include hospitalization, fetal loss in pregnancy-associated cases, and notable case-fatality risk.
Researchers at Stony Brook University developed an oral vaccine using modified Listeria monocytogenes that generates anti-tumor immune responses in the gut and significantly improves colorectal cancer control when combined with checkpoint inhibitors.
Researchers have developed attenuated Listeria bacteria therapies that boost innate immune cells to fight cancer. Two approaches target colorectal cancer and pediatric leukemia, with FDA clearance expected soon for trials in children.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT03357536 |
Genetic Susceptibility to Listeriosis |
RECRUITING | NA |
| NCT02924220 |
Genetic Susceptibility and Biomarkers in Listeriosis |
COMPLETED | |
| NCT01520597 |
National Study on Listeriosis and Listeria |
COMPLETED |
