Hypoplastic left heart syndrome is a severe congenital heart defect characterized by underdevelopment of left-sided cardiac structures, resulting in critically impaired systemic circulation. Newborns typically require staged surgical palliation and intensive lifelong follow-up. Without intervention, the condition is usually fatal in infancy.
Longeveron Inc. announced Phase 2b clinical trial results published in Cell Stem Cell showing laromestrocel improved physical condition in patients with age-related frailty after nine months compared to placebo.
Longeveron Inc. appointed Stephen H. Willard as CEO effective February 11, 2026, replacing interim CEO Than Powell. The appointment comes as the company expects top-line results from its pivotal Phase 2b trial for Hypoplastic Left Heart Syndrome in Q3 2026.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT06711666 |
Prenatal Maternal Mental Health and Neurodevelopment in Congenital Heart Disease |
RECRUITING | |
| NCT06461676 |
Study of Intramyocardial Injection of Ventrix Bio Extracellular Matrix (VentriGel) to Assess the Safety and Feasibility in Pediatric Patients with Hypoplastic Left Heart Syndrome (HLHS) |
NOT_YET_RECRUITING | PHASE1 |
| NCT06342999 |
Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome |
ENROLLING_BY_INVITATION | NA |
| NCT05709275 |
Hypoplastic Left Heart Syndrome: Subendocardial Viability After Norwood Palliation |
TERMINATED | |
| NCT05386173 |
Effect of Fetal Aortic Valvuloplasty on Outcomes |
RECRUITING | |
| NCT04925024 |
Evaluation of Lomecel-Bâ„¢ Injection in Patients With Hypoplastic Left Heart Syndrome (HLHS): A Phase IIb Clinical Trial. |
ACTIVE_NOT_RECRUITING | PHASE2 |
| NCT04581668 |
Impact of NAVA Ventilation on Brain Oxygenation and Perfusion in Children With Congenital Heart Disease |
UNKNOWN | NA |
| NCT04452188 |
Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative Period |
COMPLETED | NA |
| NCT04181255 |
Cold Heart Study: A Randomized Pilot Trial of Surfactant Therapy |
TERMINATED | PHASE1 |
| NCT04056416 |
Physical Activity Promotion in Children and Adolescents With Single Ventricle Physiology (MedBike) |
COMPLETED | NA |
