High grade gliomas are a group of aggressive malignant intrinsic brain tumors, typically WHO grade III and IV, including anaplastic gliomas and glioblastoma. They are associated with high recurrence rates and poor prognosis despite multimodal therapy. Management generally includes surgery plus chemoradiation.
Johnson & Johnson invests over $1 billion in a new Pennsylvania cell therapy manufacturing facility for cancer and neurological diseases. The expansion addresses growing demand for advanced therapies while highlighting workforce training challenges in GMP environments. Other developments include new cell line technology for viral vector production and CRISPR-edited CAR-T manufacturing partnerships.
Cellectar Biosciences said it will report full-year 2025 financial results and provide a corporate update on March 4, 2026. The company also shared conference call, webcast, and replay details.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07710040 |
Preoperative Proton Irradiation for High-grade Brain Gliomas. |
RECRUITING | PHASE1 |
| NCT07670455 |
Brain Radiotherapy Imaging for High-grade Glioma Using Hypoxia Targeting Through Oxygen-Enhanced Response |
NOT_YET_RECRUITING | NA |
| NCT07664176 |
NgFUS NIVO: NeuroNavigation-Guided Focused Ultrasound With Nivolumab in Relapsed and Progressive DMG and Other High Grade Brain Tumors |
NOT_YET_RECRUITING | PHASE1 |
| NCT07649070 |
Phase 2 Trial of G207 + 5 Gy Radiation for Children With High-Grade Gliomas |
NOT_YET_RECRUITING | PHASE2 |
| NCT07635173 |
SM-1 Combined With Temozolomide in Subjects With Refractory or Recurrent High-Grade Gliomas |
COMPLETED | PHASE1 |
| NCT07439172 |
Pre-Radiation Chemotherapy for Newly Diagnosed High-Grade Glioma. |
NOT_YET_RECRUITING | PHASE2 |
| NCT07346144 |
Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma |
RECRUITING | PHASE1/PHASE2 |
| NCT07331064 |
Gallium Maltolate for the Treatment of Pediatric Patients With Relapsed or Refractory Pediatric High-Grade Glioma and Atypical Teratoid Rhabdoid Tumor |
NOT_YET_RECRUITING | PHASE1 |
| NCT07210632 |
Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG) |
RECRUITING | EARLY_PHASE1 |
| NCT07061626 |
Determine Maximum Tolerated Dose, Safety, and Tolerability of Rhenium (186Re) in Pediatric Recurrent, Refractory or Progressive Ependymoma and High-Grade Glioma |
NOT_YET_RECRUITING | PHASE1 |
