GVHD stands for graft-versus-host disease, an alloimmune complication after allogeneic stem-cell or bone marrow transplantation in which donor immune cells attack recipient tissues. It can present as acute or chronic disease with multisystem involvement. GVHD is a major determinant of post-transplant morbidity and mortality.
Interim results from the ABC phase 1/2b trial show a calcineurin inhibitor-free GVHD prevention regimen combining posttransplant cyclophosphamide, bortezomib, and abatacept achieved low GVHD rates and favorable survival outcomes. The approach enables earlier introduction of posttransplant maintenance therapies while reducing toxicity associated with conventional immunosuppressants.
Researchers developed BIOPREVENT, an AI-based tool that predicts chronic graft-versus-host disease and transplant-related mortality in stem cell and bone marrow transplant patients by analyzing blood biomarkers and clinical data collected 90-100 days post-transplant.
CAR-T cell therapy engineering advances at Tandem 2026 focus on reducing toxicity and improving access, while McGill researchers develop targeted nanoparticle immunotherapy for lymph node metastases with fewer side effects.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07570407 |
Quantification of Peripheral Blood iNKTs After Allogeneic Stem Cell Transplantation |
NOT_YET_RECRUITING | |
| NCT07508345 |
Endothelial Dysfunction as a Predictive Marker of Acute Graft-Versus-Host Disease in Adult Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation |
COMPLETED | |
| NCT07314892 |
Psychiatric Status and Symptom Severity in Graft-versus-Host Disease (GvHD). |
RECRUITING | |
| NCT07302776 |
TACrolimus Targeted Immunosuppression Cessation in ALlogeneic HCT |
NOT_YET_RECRUITING | PHASE1 |
| NCT07014059 |
Autologous Serum Obtained by a Closed-Circuit Collection Device |
NOT_YET_RECRUITING | PHASE2 |
| NCT06995521 |
Vorinostat for Graft-versus-host Disease (GVHD) Prevention in Non-Malignant Adolescent and Young Adults (AYA) Population |
NOT_YET_RECRUITING | PHASE2 |
| NCT06938165 |
The Safety and Efficacy of Fecal Microbiota Transplant (FMT) for Steroid-refractory Graft-versus-host Disease |
COMPLETED | NA |
| NCT06590285 |
Diagnostic Refinement and Educational Approaches in Managing Bone Marrow Transplantation |
RECRUITING | NA |
| NCT06469411 |
Effect of PMSCs and Their Secretome for the Treatment of GvHD |
COMPLETED | PHASE3 |
| NCT06462365 |
Prevention of GvHD in Participants With Hematological Malignancies Undergoing Hematopoietic Stem Cell Transplant (HSCT) |
RECRUITING | PHASE1 |
