Erectile dysfunction is the persistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It is a multifactorial condition with organic, psychogenic, and mixed etiologies, and is strongly associated with cardiometabolic comorbidities and age. It can substantially affect quality of life and mental health.
Diabetes and heart disease can impair sexual function by damaging blood vessels, nerves and circulation. Sexual dysfunction may also be an early warning sign of underlying vascular damage.
GLP-1 drugs are expanding in 2026 with oral semaglutide for weight management, rising patient use and broader commercialization. A study also found a modest increase in erectile dysfunction risk among men with Type 2 diabetes starting GLP-1 medicines, though the association weakened after stricter adjustment.
GLP-1 drugs discovered accidentally in anglerfish research now treat conditions beyond diabetes including kidney disease, sleep apnea, and addiction. The global diabetes therapeutics market is projected to reach $241.5 billion by 2030, growing at 12.4% annually.
Ten-year survival data show salvage focal therapy using heat or cold ablation is as effective as radical prostatectomy for treating localized prostate cancer recurrence after radiotherapy, with significantly fewer complications and better quality of life.
A major meta-analysis of 19 randomized trials involving 123,940 participants found that only six side effects are actually caused by statins, challenging long-standing concerns about the drugs' safety profile.
Pfizer is applying lessons from its Viagra launch to introduce its first obesity treatment, a monthly injection acquired from Metsera. The company aims to leverage past experience with sensitive health topics as it enters the competitive obesity market.
A matched analysis of 923 men found salvage focal therapy and radical prostatectomy achieved comparable 10-year cancer-specific survival for prostate cancer recurring after radiotherapy, though surgery carried significantly higher complication rates.
The Trump administration launched TrumpRx.gov in February 2026, offering discounted prices on dozens of brand-name prescription drugs through negotiated deals with pharmaceutical companies, though critics warn many listed drugs have cheaper generic alternatives.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07602608 |
Platelet-Rich Plasma With or Without Tadalafil for Erectile Dysfunction |
COMPLETED | PHASE4 |
| NCT07592533 |
A Single Arm Study of Extracorporeal Shockwave Therapy for Management of Erectile Dysfunction |
RECRUITING | NA |
| NCT07574268 |
Efficacy of Transcutaneous Electrical Neural Stimulation and Tadalafil in Men With Erectile Dysfunction: A Randomized, Double-Blind, Bi-centric, Placebo- and Sham-Controlled Trial |
COMPLETED | PHASE4 |
| NCT07563647 |
Association Between Diastolic Dysfunction and Erectile Dysfunction and the Effect of Tadalafil and SGLT2 Inhibitors on Them in Men With Metabolic Syndrome |
COMPLETED | PHASE4 |
| NCT07544537 |
A Prospective Comparative Study of Autologous Bone Marrow-Derived and Adipose Tissue-Derived Mesenchymal Stem Cells Versus Platelet-Rich Plasma and Standard Therapy in Patients With Organic Erectile Dysfunction |
ACTIVE_NOT_RECRUITING | PHASE2 |
| NCT07537855 |
Efficacy of Intracavernosal Xeomin With Tadalafil for Mild-Moderate Erectile Dysfunction |
NOT_YET_RECRUITING | PHASE2 |
| NCT07460167 |
Penile Rehabilitation in Patients With Erectile Dysfunction After Pelvic Fracture Urethral Injury Using Low-intensity Shock Wave. |
COMPLETED | NA |
| NCT07451808 |
Male Pelvic Floor Muscle Rehabilitation Exercises |
NOT_YET_RECRUITING | NA |
| NCT07442396 |
The Effectiveness of Exercise in the Treatment of Erectile Dysfunction and Premature Ejaculation |
RECRUITING | NA |
| NCT07431008 |
Safety Follow-up Study of Cellgram-ED in Post-Radical Prostatectomy Erectile Dysfunction |
RECRUITING |
