A phase 2 clinical trial published in The Lancet Gastroenterology & Hepatology found that dupilumab significantly improved symptoms and biological markers in patients with eosinophilic gastritis, a rare stomach disease with no approved treatments. The DEGAS study involved 41 patients across 11 U.S. centers.
Kymera Therapeutics presented Phase 1 data for oral STAT6 degrader KT-621 in healthy Japanese adults, showing ≥98% STAT6 degradation and favorable safety. Parallel Phase 2b trials in atopic dermatitis and asthma are ongoing with data expected in 2027, and FDA has granted Fast Track designation for both indications.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07588568 |
A Trial of Upadacitinib for Non-responsive Eosinophilic Esophagitis |
NOT_YET_RECRUITING | PHASE2 |
| NCT07227506 |
Utility of Mucosal Impedance Device in Chronic Esophageal Disorders: |
RECRUITING | |
| NCT07027826 |
The Esophageal String Test as a Diagnostic Screening Tool for Eosinophilic Esophagitis Among Africans With Dysphagia in Mali and the United States |
RECRUITING | NA |
| NCT06972147 |
Prevalence and Description of FIRE (Food Induced Immediate Response of the Esophagus) in the Pediatric Population With Eosinophilic Esophagitis |
RECRUITING | |
| NCT06851559 |
A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks |
ACTIVE_NOT_RECRUITING | PHASE2 |
| NCT06596252 |
Once Daily Versus Twice Daily Budesonide Orodispersible Tablets for Induction of Remission in EoE |
RECRUITING | PHASE3 |
| NCT06501274 |
Capsule Sponge Study in Eosinophilic Oesophagitis |
COMPLETED | NA |
| NCT05583227 |
Efficacy and Safety of Tezepelumab in Patients With Eosinophilic Esophagitis |
ACTIVE_NOT_RECRUITING | PHASE3 |
| NCT05176262 |
A Prospective Study of the Four Food Elimination Diet for Treatment of Eosinophilic Esophagitis |
ACTIVE_NOT_RECRUITING | |
| NCT05176249 |
Prospective Database for Eosinophilic Esophagitis (EoE) of Pediatric Population |
ACTIVE_NOT_RECRUITING |
