Also known as: gallstones
Cholelithiasis is the presence of gallstones in the gallbladder or biliary tract. It may be asymptomatic or cause biliary pain and complications such as cholecystitis or pancreatitis.
The UK MHRA approved oral semaglutide (Wegovy) as the first GLP-1 weight loss tablet on 11 June 2026. A new report links high-dose tirzepatide to anhedonia, and data show bariatric surgery declining sharply as GLP-1 use surges.
The FDA has announced plans to crack down on active pharmaceutical ingredients used in compounded GLP-1 drugs and warned about the risks of these products. The agency has cited counterfeit products, non-FDA-approved ingredients and more than 1,000 adverse event reports tied to compounded semaglutide and tirzepatide.
GLP-1 weight loss drugs show increasing efficacy but raise concerns about excessive weight loss, side effects, and the rise of unregulated compounded versions sold online.
A 30-year-old female with stage IV gallbladder adenocarcinoma achieved complete metabolic resolution of metastases after three cycles of pembrolizumab, gemcitabine, and cisplatin, despite presenting without traditional risk factors.
Clinical studies demonstrate GLP-1 receptor agonists like semaglutide and tirzepatide produce substantial weight loss when combined with lifestyle changes, with patients achieving mean reductions of 14.9% body weight over 68 weeks.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07758803 |
A Randomized Controlled Trial Comparing the Effects of Different Anesthetic Sedatives on PONV in Laparoscopic Cholecystectomy |
RECRUITING | PHASE4 |
| NCT07717684 |
Time to Loss of Consciousness With Remimazolam Versus Propofol for Anesthetic Induction in Laparoscopic Cholecystectomy |
RECRUITING | PHASE4 |
| NCT07676552 |
Rectointercostal Plane Block (RICPB) for Laparoscopic Cholecystectomy |
NOT_YET_RECRUITING | NA |
| NCT07655778 |
EUS-Guided Gallbladder Drainage Versus Conservative Management in Patients Unfit for Surgery After a Biliary Event Without Cholecystitis. DRECON Study |
NOT_YET_RECRUITING | NA |
| NCT07649811 |
Endoscopic vs Non-endoscopic Drainage for Benign Gallbladder Diseases in High-risk Patients or Patients Desiring Gallbladder Preservation |
NOT_YET_RECRUITING | |
| NCT07637721 |
Supraglottic Oxygenation Via Oral Transtracheal Catheter for Reducing the Incidence of Hypoxemia During ERCP Under Sedation |
NOT_YET_RECRUITING | NA |
| NCT07595692 |
Tri-Radial Port Extension for Difficult Gallbladder Extraction |
COMPLETED | NA |
| NCT07552701 |
USG-Guided TAPA vs RIFB Block for Postoperative Analgesia in Laparoscopic Cholecystectomy |
RECRUITING | NA |
| NCT07512024 |
Effects of Postoperative Video-assisted Early Mobilization on Recovery Outcomes |
NOT_YET_RECRUITING | NA |
| NCT07490730 |
Antegrade Transcystic Balloon Dilatation of the Papillary Sphincter During Emergency Laparoscopic Cholecystectomy for Common Bile Duct Stones |
COMPLETED |
