Researchers have developed a remote-controlled CAR T-cell therapy that can be switched off on demand using venetoclax, while new engineering strategies aim to overcome barriers in treating glioblastoma and other solid tumors.
An international research team has conducted the first comprehensive genetic study of cancer in domestic cats, identifying genetic changes that closely resemble those in human cancers and opening new perspectives for targeted therapies.
A study published in Science sequenced cancer-related genes in 493 cat tumor samples across 13 cancer types, revealing striking genetic similarities with human cancers and opening possibilities for shared treatments.
President Trump signed a spending package funding the National Institutes of Health at nearly $49 billion, the highest level ever, reversing his earlier push for a 40% budget cut to medical research.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07539441 |
A Study of Mirdametinib in People With Central Nervous System Tumors |
RECRUITING | PHASE1/PHASE2 |
| NCT05308407 |
POWER UP: Participating Online While Exercising to Recover Using Play |
TERMINATED | NA |
| NCT05235074 |
OH2 Oncolytic Viral Therapy in Central Nervous System Tumors |
RECRUITING | PHASE1/PHASE2 |
| NCT05081180 |
Study of Avelumab in Combination With Lenvatinib for Children With Primary CNS Tumors |
ACTIVE_NOT_RECRUITING | PHASE1 |
| NCT03050450 |
Study of Lenalidomide With Vorinostat in Pediatric Patients With High Grade or Progressive CNS Tumors |
TERMINATED | PHASE1 |
| NCT02793466 |
Durvalumab in Pediatric and Adolescent Patients |
COMPLETED | PHASE1 |
| NCT02462629 |
Study of BLZ-100 in Pediatric Subjects With CNS Tumors |
COMPLETED | PHASE1 |
| NCT01985451 |
Pemetrexed and Temozolomide in Treating Patients With Relapsed Primary Central Nervous System Lymphoma （PCNSL） |
UNKNOWN | PHASE2 |
| NCT01735747 |
Temozolomide, Nedaplatin, Vincristine, and Radiotherapy as First-line Treatment in Newly Diagnosed Primary CNS Lymphoma |
UNKNOWN | PHASE2 |
| NCT01164189 |
Bevacizumab in Recurrent Grade II and III Glioma |
COMPLETED | PHASE2 |
