Breast cancer is a malignant disease in which abnormal cells in breast tissue grow uncontrollably and can invade surrounding tissue or spread to distant sites.
A study published in The Journal of Clinical Investigation found that CXCL11 may help drive endocrine resistance in some hormone receptor-positive breast cancers. Researchers said ED-resistant tumors had increased immune signaling and may be more responsive to immunotherapies.
Samsung Bioepis plans to start a global Phase 1 trial of SBE303, its first independently developed new drug candidate targeting Nectin-4. Preclinical data showed tolerability up to 40 mg/kg in monkeys.
Trastuzumab deruxtecan is moving into earlier treatment lines for HER2-positive metastatic breast cancer, demonstrating superior efficacy over standard regimens and prompting reconsideration of long-standing treatment sequences.
New research warns AI pathology systems may use statistical shortcuts rather than biological signals, while a clinical trial shows stereotactic radiation improves quality of life for patients with multiple brain metastases compared to whole brain radiation.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07095023 |
Neoadjuvant Oral Paclitaxel Plus Subcutaneous Pertuzumab/Trastuzumab in Patients With HER2-positive Breast Cancer |
RECRUITING | NA |
| NCT07018505 |
EpCAM-Targeted Surface-Enhanced Raman Spectroscopy Nanotags for Rapid Evaluation of Surgical Margins and Sentinel Lymph Node Metastasis Status in Breast Cancers |
NOT_YET_RECRUITING | |
| NCT06960291 |
Sustainable Implementation of the EXCEL Exercise Oncology Program Across Canada |
RECRUITING | NA |
| NCT06956443 |
Prediction of ICG for Skin Necrosis in Mastectomy With Immediate Reconstruction |
NOT_YET_RECRUITING | |
| NCT06954623 |
Partial Breast Re-irradiation for Breast Cancer |
RECRUITING | NA |
| NCT06943313 |
Breast Cancer PET/CT Imaging With 68Ga-pAKTi |
ENROLLING_BY_INVITATION | |
| NCT06856876 |
Examining the Effectiveness of Multidisciplinary Care Teams in Improving Outcomes for Breast Cancer Patients |
COMPLETED | NA |
| NCT06825975 |
A Phase II Single-Arm Clinical Study to Explore the Efficacy and Safety of Hyperbaric Oxygen in the Neoadjuvant Treatment of Triple-Negative and HER2+ Breast Cancer Patients |
NOT_YET_RECRUITING | NA |
| NCT06825949 |
A Clinical Study to Explore the Efficacy and Safety of Hyperbaric Oxygen in the Neoadjuvant Treatment of Hormone Receptor Positive Breast Cancer Patients |
NOT_YET_RECRUITING | NA |
| NCT06819501 |
Hyperbaric Oxygen Therapy for Peripheral Neuropathy Due to Paclitaxel Analogs |
NOT_YET_RECRUITING | NA |
