Research reveals how ectopic NMDA receptor expression in triple-negative breast cancer triggers autoimmune disease through antibody maturation. The study shows NMDAR expression recruits B cells and drives affinity maturation, producing antibodies that can cross the blood-brain barrier and cause neurological symptoms while constraining tumor growth.
Grail's NHS-Galleri trial of 142,000 participants failed to achieve statistically significant reduction in late-stage cancer diagnoses, though secondary endpoints showed four-fold improvement in overall cancer detection rate. Stock fell 48% following the announcement.
New research warns AI pathology systems may use statistical shortcuts rather than biological signals, while a clinical trial shows stereotactic radiation improves quality of life for patients with multiple brain metastases compared to whole brain radiation.
Merck is diversifying its oncology pipeline beyond Keytruda as the blockbuster approaches patent cliffs, focusing on immune modulating therapies, antibody-drug conjugates, and tumor intrinsic treatments through strategic acquisitions and partnerships.
New research demonstrates that physical activity after cancer diagnosis reduces mortality risk in less common cancers and enhances circadian clock function in tumor tissue, supporting exercise as a therapeutic intervention.
Novartis announced plans to establish a 46,000-square-foot radioligand therapy manufacturing site in Denton, Texas, as part of its $23 billion US expansion. The facility is expected to be operational in 2028.
The global oncology precision medicine market is projected to grow from $190.50 billion in 2026 to $366.53 billion by 2033 at a 9.8% CAGR, while the cancer biomarker testing market is expected to reach $96.53 billion by 2033 at a 12.6% CAGR.
The FDA approved Optune Pax, a wearable Tumor Treating Fields device, for locally advanced pancreatic cancer in combination with gemcitabine and nab-paclitaxel. The approval marks the first new treatment for this indication in nearly 30 years.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07370051 |
Effect of Topical Oxygen and LED Light Therapy on Nipple Crack |
NOT_YET_RECRUITING | NA |
| NCT07252986 |
Clinical Translation Research on a Multi-omics Breast Cancer Distant Metastasis Prediction Model Empowered by Artificial Intelligence |
RECRUITING | |
| NCT07156006 |
Breast Arterial Calcifications as an Imaging Biomarker of Cardiovascular Risk |
TERMINATED | |
| NCT06791161 |
A Multicenter Prospective Cohort Study of Adjuvant Therapy for BRCA1/2 Mutated Hormone Receptor-positive HER2-negative Early High-risk Breast Cancer |
ENROLLING_BY_INVITATION | |
| NCT06382272 |
A Bionic Breast Project Using Neuroprosthesis to Reduce Chronic Pain After Mastectomy |
RECRUITING | NA |
| NCT06162351 |
A Study to Evaluate the Efficacy and Toxicities of PLX038, in Patients With Locally Advanced or Metastatic Triple-negative Breast Cancer |
TERMINATED | PHASE2 |
| NCT06157879 |
Measuring Electrical Properties of Breast Tissues |
COMPLETED | NA |
| NCT06083415 |
Early Breast Growth in Girls Aged 6 to 8 Years in the Current Environmental Context |
RECRUITING | NA |
| NCT05720039 |
Robotic vs. Open NSM for Early Stage Breast Cancer |
ACTIVE_NOT_RECRUITING | NA |
| NCT05663801 |
Magnesium Sulphate Versus Ketamine as an Adjuvant to Bupivacaine in Pectoral Nerve Block During Mastectomy |
COMPLETED | PHASE2 |
