Also known as: brain fog
University of Galway researchers identified that targeting GABA signaling, specifically α5-GABA A receptors, can restore neural balance and improve memory in Alzheimer's disease models, offering a potential new therapeutic approach distinct from current excitatory-focused treatments.
Vaccine denial and weakened public health measures risk increasing chronic illness, as historical data shows post-infectious conditions follow major outbreaks. Long COVID affects 10-20% of those infected, while historical pandemics led to conditions like encephalitis lethargica with near 50% mortality.
Two new studies reveal long COVID's lasting biological and mental health effects. A mouse study found coronavirus triggers prolonged lung and brain damage unlike influenza, while a population study linked long COVID to significantly higher depression and anxiety risks up to three years post-infection.
Acromegaly patients face persistent symptoms including fatigue, joint pain, headaches, and brain fog despite biochemical control. Treatment burden and financial barriers remain significant, particularly in sub-Saharan Africa where diagnostic tools and therapies are often inaccessible.
A 16-year study links higher vitamin D levels in middle age to lower tau protein deposits in the brain, while a major COVID-19 trial finds vitamin D doesn't reduce acute severity but may help with long COVID recovery. Separate research shows supplementation improves vitamin D levels and stabilizes immune profiles in athletes and non-athletes.
Amylyx Pharmaceuticals is advancing avexitide toward potential FDA approval for post-bariatric hypoglycemia, with Phase 3 LUCIDITY trial results expected in Q3 2026 and a cash runway extending into 2028.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07742657 |
A Clinical Trial to Evaluate the Effects of Super Liver Liquid Drops on Gut Health, Digestive Comfort, and Daily Energy Levels |
ACTIVE_NOT_RECRUITING | NA |
| NCT07742605 |
A Clinical Trial to Evaluate the Effects of a Supplement on Cognitive Performance |
COMPLETED | NA |
| NCT07721506 |
A Clinical Trial to Evaluate the Effects of the Edge+Ease PM+AM System on Mood, Mental Clarity, Sleep Quality, and Digestive Wellbeing |
NOT_YET_RECRUITING | NA |
| NCT07523113 |
ME/CFS Brain Fog: Cognitive Rehabilitation Trial |
NOT_YET_RECRUITING | NA |
| NCT07396779 |
Cognitive Task-Based Walking Effects on Cognition, Mood, Sleep, and Quality of Life in Older Adults With Brain Fog |
COMPLETED | NA |
| NCT07005921 |
Attention, Memory and Quality of Life in Post-COVID-19 Adults |
COMPLETED | NA |
| NCT06586398 |
A Pilot rTMS Trial for Neuropsychiatric Symptoms of Long-COVID |
COMPLETED | NA |
