News Related to Autoimmune Disease

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Autolus Reports $74.3M Revenue in First Commercial Year, Aims for Positive Margins by 2026

Mar 28, 2026

Autolus Therapeutics reported $74.3 million in 2025 revenue during its first commercial year, while facing a -265% gross margin. The company aims to achieve positive margins by 2026 through scaling production and expanding into autoimmune diseases with promising early lupus trial results. The broader CAR-T therapy market is projected to reach $9.85 billion in the US by 2033.

CRISPR Therapeutics Reports Wider-Than-Expected Q4 Loss, Sales Miss Estimates

Mar 28, 2026

CRISPR Therapeutics reported a Q4 2025 loss of $1.37 per share, missing estimates, with revenues of $0.9 million falling short of expectations. The company's partner Vertex recorded $54 million in Casgevy sales for the quarter, with regulatory submissions for pediatric label expansion planned for early 2026.

Ectopic NMDAR Expression in Cancer Triggers Autoimmunity Through Antibody Maturation

Mar 26, 2026

Research reveals how ectopic NMDA receptor expression in triple-negative breast cancer triggers autoimmune disease through antibody maturation. The study shows NMDAR expression recruits B cells and drives affinity maturation, producing antibodies that can cross the blood-brain barrier and cause neurological symptoms while constraining tumor growth.

Monash University Partners with Ono Pharmaceutical for Autoimmune Disease Therapies

Mar 23, 2026

Monash University and Ono Pharmaceutical have signed two licence agreements for the development of anti-GPCR antibodies targeting autoimmune and inflammatory diseases. The agreements result from Ono exercising options on research collaborations announced in 2023. The partnership combines Monash's research excellence with Ono's drug development capabilities to address unmet medical needs.