Atherosclerotic Cardiovascular Disease

Disease

Disease Profile

Atherosclerotic cardiovascular disease (ASCVD) is cardiovascular disease caused by atherosclerotic plaque buildup in arterial walls, leading to conditions such as coronary artery disease, stroke, and peripheral arterial disease.

Category
Cardiovascular disease
ICD Codes
  • I25.1

Related News

Arrowhead Pharmaceuticals Reports Strong Long-Term Data for Plozasiran in Hypertriglyceridemia

Arrowhead Pharmaceuticals presented long-term data showing plozasiran achieved 83% median triglyceride reduction in severe hypertriglyceridemia patients with no acute pancreatitis events over two years. The RNA interference therapy demonstrated durable improvements in atherogenic lipoproteins and consistent safety profile. The company plans to complete Phase 3 studies by mid-2026 and submit for regulatory approval.

Eli Lilly Acquires Rights to CSL's IL-6 Inhibitor in $100M Deal

Eli Lilly has acquired rights to CSL's IL-6 inhibitor clazakizumab in a $100 million deal, expanding its cardiometabolic pipeline. The monoclonal antibody targets chronic inflammation, particularly in cardiovascular conditions. This move follows Lilly's successful obesity and diabetes drugs that drove $65.1 billion in 2025 revenue.

Shingles Vaccine Reduces Cardiovascular Events in Heart Disease Patients by 46%

A new study of over 246,000 heart disease patients shows the shingles vaccine reduces major cardiovascular events by 46% and death by 61% within one year. The protective effects are comparable to quitting smoking and support existing vaccine recommendations for adults over 50. The findings will be presented at the American College of Cardiology's annual meeting.

Oral Semaglutide Shows Broad Cardiometabolic Benefits in Type 2 Diabetes Trial

Oral semaglutide demonstrated significant improvements in multiple cardiometabolic risk factors in adults with type 2 diabetes at high cardiovascular risk. The SOUL trial analysis showed reductions in systolic blood pressure, cholesterol, triglycerides, HbA1c, and body weight compared to placebo. These benefits were observed as early as 13 weeks and contributed to a 14% reduction in major adverse cardiovascular events.

Related Clinical Trials

NCT ID Title Status Phase
NCT07594392

Clinical Assessment and Targeted Imaging to Characterize High-Risk Atherosclerotic Cardiovascular Disease of Survivors in SJLIFE

NOT_YET_RECRUITING
NCT07551492

A Phase III Study To Evaluate the Efficacy And Safety Of HRS9531 In Participants With Atherosclerotic Cardiovascular Disease

NOT_YET_RECRUITING PHASE3
NCT07543731

A Real-World Study of Long-Term Adherence and Persistence to Inclisiran, Evolocumab, and Alirocumab

NOT_YET_RECRUITING
NCT07203677

Comparative Effectiveness of Tirzepatide Versus Sitagliptin in Individuals at Cardiovascular Risk (TIRZSITA-CVOT)

COMPLETED
NCT07160829

Focus on Levels of Awareness and Perceptions Regarding hsCRP in Identifying Systemic Inflammation in ASCVD, CKD and Heart Failure Management

COMPLETED
NCT07037433

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

RECRUITING PHASE3
NCT07034690

Study to Evaluate the Impact of a Targeted Lipid Optimization Program on LDL-C Control in At-risk Adult Patients With Dyslipidemia

RECRUITING PHASE4
NCT07023445

Patterns of Inclisiran Use in the Real World: An Analysis of US Databases

COMPLETED
NCT06962488

Polygenic Risk Score Implementation and Stratification for Managing Blood Pressure

RECRUITING NA
NCT06875973

Pelacarsen Roll-over Extension Program

RECRUITING PHASE3