Updated pediatric hypertriglyceridemia guidance says triglyceride thresholds below 400 mg/dL mainly signal ASCVD risk, while levels above about 885 mg/dL raise pancreatitis risk. Lifestyle changes remain first-line treatment, and pediatric-specific evidence for drug therapy is still limited.
Enlicitide decanoate demonstrated efficacy in reducing LDL cholesterol levels compared to placebo in patients with atherosclerotic cardiovascular disease history or risk, according to phase 3 CORALreef Lipids trial data.
A systematic review of 64 randomized clinical trials found GLP-1 receptor agonists produce greater weight loss in women than men, while the global market is projected to grow from $51.57 billion in 2026 to $112.62 billion by 2032.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07522645 |
Adherence to Dyslipidemia Therapy: Harnessing Evidence From Randomized Evaluations in AtheroSclerotic CardioVascular Disease |
NOT_YET_RECRUITING | NA |
| NCT07491978 |
Development and Multicenter Validation of an AI-Based Remote Photoplethysmography (rPPG) Facial Scan for Multimodal Health Assessment |
NOT_YET_RECRUITING | |
| NCT07417618 |
INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without ASCVD (INTERCEPT-ASCVD) |
ACTIVE_NOT_RECRUITING | |
| NCT07303777 |
Efficacy, Safety, and PopPK Profile of ABP-745 in Patients With Atherosclerosis |
RECRUITING | PHASE2 |
| NCT07270887 |
The Long-term Effect of Remote Ischemic Conditioning on Main Organs in ASVCD Patients With Very High Risks |
RECRUITING | |
| NCT07117695 |
Duke Cardiometabolic Prevention Clinic's Impact on High-risk Cardiovascular Patients With Uncontrolled Risk Factors |
NOT_YET_RECRUITING | NA |
| NCT06960655 |
Improving Lipid Optimization Quality and Treatment Options in ASCVD |
ENROLLING_BY_INVITATION | NA |
| NCT06767774 |
Comparison of Pitavastatin Plus Ezetimibe Versus High-Intensity Statin Therapy on Risk of New-Onset Diabetes Mellitus |
RECRUITING | PHASE4 |
| NCT06691217 |
Effects of IL-1 Beta Inhibition on Vascular Inflammation in TET2 Clonal Hematopoiesis |
RECRUITING | PHASE2 |
| NCT06641661 |
NPC1L1 Gene Polymorphism and the Efficacy and Safety of Hybutimibe |
NOT_YET_RECRUITING |
