Adjunct intra-arterial alteplase after thrombectomy improved 90-day functional recovery in LVO stroke (57.5% vs 42.5%). Headache occurs in 46% of hemorrhagic stroke patients; only 21.8% of stroke/TBI patients receive inpatient rehab.
In TRIDENT, GMRx2 reduced recurrent stroke risk by 39% after intracerebral hemorrhage. LT3001 was safe in phase 2 acute ischemic stroke trials, supporting a global phase 3.
Blood-based biomarkers including brain-derived tau and amyloid-beta are enabling earlier Alzheimer's disease diagnosis through non-invasive testing, though confirmatory imaging remains necessary before treatment initiation.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07800572 |
Anisodine Hydrobromide for Patients With Acute Ischemic Stroke Undergoing Endovascular Therapy (HEAL-2) |
NOT_YET_RECRUITING | PHASE2 |
| NCT07598799 |
Rapid Local Ischemic Postconditioning on Stroke After Thrombectomy |
NOT_YET_RECRUITING | NA |
| NCT07555977 |
SUPERSTAR: Aspiration vs. Stent Retriever in Anterior Circulation LVO |
NOT_YET_RECRUITING | NA |
| NCT07361302 |
A Study to Test if Tenecteplase Helps People to Recover From an Acute Stroke When Given More Than 4.5 Hours After the Person Was Last Seen Well |
RECRUITING | PHASE3 |
| NCT07318948 |
BALANCE Trial Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632 |
RECRUITING | NA |
| NCT07263308 |
Albumin for Patients With Acute Large Vessel Occlusive Stroke Undergoing Endovascular Therapy -2 |
RECRUITING | PHASE3 |
| NCT07026331 |
Effect of Balloon Angioplasty vs Stenting Following Residual Stenosis After Endovascular Treatment of Intracranial Atherosclerotic Acute Ischemic Stroke |
RECRUITING | NA |
| NCT06878066 |
Thrombolysis in Factor Xa-inhibitors Trial |
RECRUITING | PHASE3 |
