Acne vulgaris is a chronic inflammatory skin disorder of the pilosebaceous follicles that commonly causes pimples and inflammatory lesions. It is one of the most common skin diseases and often begins during adolescence.
Magnesium supplements can interact with antibiotics and bone-loss drugs, reducing their effectiveness. High doses may cause diarrhea, nausea, and low blood pressure. Experts advise talking to a health care provider before use.
India's drug regulator has mandated stronger safety warnings for doxycycline and carbimazole after a national review of adverse reaction reports. Doxycycline packages will now list potential mental health side effects such as anxiety and dizziness, while carbimazole will warn of a rare blood disorder.
A study using FAERS and MEPS data found that oral contraceptive side effects such as acne, migraine, anxiety, and depression vary by progestin type. Drospirenone-containing pills had higher reported rates of all four, while acne was also greater with levonorgestrel and norgestimate.
Two phase 3 trials found upadacitinib 15 mg significantly improved facial and total repigmentation versus placebo at 48 weeks in nonsegmental vitiligo. The 614-patient studies also showed continued improvement over time and a safety profile consistent with prior use.
Sagimet Biosciences reported fourth quarter and full year 2025 financial results, announcing plans to initiate a Phase 2 trial of denifanstat and resmetirom combination in F4 MASH patients in the second half of 2026, with a 26-week biomarker readout expected in the first half of 2028.
The FDA has accepted Regeneron's Biologics License Application for garetosmab to treat fibrodysplasia ossificans progressiva, granting Priority Review with a target action date of August 2026. The application is supported by Phase 3 OPTIMA trial data.
The FDA has accepted Regeneron's biologics license application for garetosmab with priority review, targeting fibrodysplasia ossificans progressiva. A decision is expected by August 2026 based on Phase 3 trial data showing significant reductions in new bone lesions.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07756957 |
Safety of the Acne mRNA Vaccine in Adolescents 12 to 17 Years of Age With Moderate to Severe Acne |
NOT_YET_RECRUITING | PHASE2 |
| NCT07752368 |
A Clinical Trial Examining the Efficacy of a Novel Acne Treatment Serum |
COMPLETED | NA |
| NCT07749469 |
Safety and Efficacy of Skincare Products for Managing Mild to Moderate Acne in Individuals With Sensitive Skin |
RECRUITING | NA |
| NCT07735169 |
Clinical Observation of Skin Condition in Patients With Acne Vulgaris Using Ubiquinol, Pomegranate Peel Extract, Ceramide, and Salicylic Acid Emulsion |
NOT_YET_RECRUITING | |
| NCT07572331 |
Clinical Study Evaluating the Safety and Effectiveness of the NIRA Laser M2.1 for the Treatment of Full-Face Wrinkles |
COMPLETED | NA |
| NCT07549828 |
Sebum Metabolomics and Lipidomics for Clinical Applications |
NOT_YET_RECRUITING | NA |
| NCT07481019 |
A Randomised Controlled Trial of ePROM-Guided Flexible Scheduling in Dermatology |
NOT_YET_RECRUITING | NA |
| NCT07428954 |
Using Artificial Intelligence to Help Doctors Identify Different Skin Conditions and Improve Patient Care |
COMPLETED | |
| NCT07428915 |
Evaluating Legit.Health Plus Support for Improving Diagnosis of Generalized Pustular Psoriasis and Other Skin Conditions Among Primary Care Physicians and Dermatologists |
COMPLETED | |
| NCT07411638 |
Non-interventional Translational Study in Mild, Moderate and Severe Acne Patients |
NOT_YET_RECRUITING |
