Acne vulgaris is a chronic inflammatory skin disorder of the pilosebaceous follicles that commonly causes pimples and inflammatory lesions. It is one of the most common skin diseases and often begins during adolescence.
Two phase 3 trials found upadacitinib 15 mg significantly improved facial and total repigmentation versus placebo at 48 weeks in nonsegmental vitiligo. The 614-patient studies also showed continued improvement over time and a safety profile consistent with prior use.
Sagimet Biosciences reported fourth quarter and full year 2025 financial results, announcing plans to initiate a Phase 2 trial of denifanstat and resmetirom combination in F4 MASH patients in the second half of 2026, with a 26-week biomarker readout expected in the first half of 2028.
The FDA has accepted Regeneron's Biologics License Application for garetosmab to treat fibrodysplasia ossificans progressiva, granting Priority Review with a target action date of August 2026. The application is supported by Phase 3 OPTIMA trial data.
The FDA has accepted Regeneron's biologics license application for garetosmab with priority review, targeting fibrodysplasia ossificans progressiva. A decision is expected by August 2026 based on Phase 3 trial data showing significant reductions in new bone lesions.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07572331 |
Clinical Study Evaluating the Safety and Effectiveness of the NIRA Laser M2.1 for the Treatment of Full-Face Wrinkles |
COMPLETED | NA |
| NCT07549828 |
Sebum Metabolomics and Lipidomics for Clinical Applications |
NOT_YET_RECRUITING | NA |
| NCT07428954 |
Using Artificial Intelligence to Help Doctors Identify Different Skin Conditions and Improve Patient Care |
COMPLETED | |
| NCT07428915 |
Evaluating Legit.Health Plus Support for Improving Diagnosis of Generalized Pustular Psoriasis and Other Skin Conditions Among Primary Care Physicians and Dermatologists |
COMPLETED | |
| NCT07411638 |
Non-interventional Translational Study in Mild, Moderate and Severe Acne Patients |
NOT_YET_RECRUITING | |
| NCT07368764 |
The Suitability of Tience® for Treating Acne Scars |
RECRUITING | NA |
| NCT07366229 |
Topical Application of Engineered Lactobacillus Reuteri With a Zinc Sulfate-Tannic Acid MPN Coating for Acne |
RECRUITING | PHASE2 |
| NCT07341659 |
Efficacy of Cosmetic Product RV3278B-OS0386 in the Maintenance Phase After Oral Isotretinoin Treatment of Adults Subjects With Facial Acne. |
ACTIVE_NOT_RECRUITING | NA |
| NCT07341087 |
Skin Inflammation in (Peri)Menopause: A Probiotic Intervention Proof of Concept Trial |
RECRUITING | NA |
| NCT07296523 |
Expert Consensus on the Use of Isotretinoin in Acne Vulgaris: A Delphi Study |
ENROLLING_BY_INVITATION |
