A Nature Communications study reported that STING agonist 8803 inhibited tumor growth in human meningioma samples and reduced tumor volume and mortality in mouse models. Researchers found the STING pathway is expressed in both meningioma tumor cells and immune cells in the tumor microenvironment.
Northwestern Medicine scientists discovered that N-acetyl-L-leucine (NALL), an FDA-approved compound, promotes neuroprotective effects in experimental Parkinson's disease models by targeting multiple molecular pathways simultaneously.
Northwestern Medicine researchers identified a potent immunotherapy approach targeting the STING pathway for meningiomas, the most common primary brain tumor. The experimental drug STING agonist 8803 triggered tumor cell death and immune responses in human samples and mouse models.
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|---|---|---|---|
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ENROLLING_BY_INVITATION | NA |
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WITHDRAWN | NA |
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RECRUITING | |
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ENROLLING_BY_INVITATION | NA |
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COMPLETED | NA |
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RECRUITING | NA |
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COMPLETED | PHASE1 |
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ACTIVE_NOT_RECRUITING | NA |
