News Related to Merck KGaA

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Organoid Models Gain Validation as Predictive Tools in Drug Development

Apr 01, 2026

Patient-derived organoids demonstrate clinically meaningful predictive value in drug development, with validation studies showing concordance between organoid drug-response profiles and patient outcomes. These models enable earlier go/no-go decisions and more rational clinical trial design, as evidenced by their use in developing FDA Breakthrough Therapy designated candidates.

RNA-Targeting Small Molecules Gain Momentum as Drug Discovery Frontier

Feb 27, 2026

Pharmaceutical companies are increasingly partnering with biotechs developing RNA-targeting small molecules, driven by advances in RNA structural biology and the success of drugs like Roche's Evrysdi. The approach aims to address "undruggable" targets while offering oral availability advantages.