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UK Puberty Blocker Trial Paused After Regulator Raises Age and Safety Concerns

Feb 22, 2026

The Pathways clinical trial into puberty blockers has been paused after the MHRA raised concerns about minimum age limits and unquantified long-term biological risks, with recruitment now suspended pending resolution.

UK Regulator Pauses PATHWAYS Puberty Blocker Trial Over Safety Concerns

Feb 21, 2026

The MHRA has raised new safety concerns about the PATHWAYS clinical trial investigating puberty blockers in young people with gender incongruence, pausing preliminary work until issues are resolved with sponsor King's College London.