Clinical Trials

NCT04967183 | ACTIVE_NOT_RECRUITING | NA

3788 participants

Polyprev: Study to Compare Fecal Immunochemical Test With Endoscopic Surveillance After Advanced Adenoma Resection in Fecal Immunochemical Test Colorectal Cancer Screening Programs.

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2022-06-01

Completion:

2026-04-12

Conditions

• Colorectal Cancer

Interventions

• DIAGNOSTIC_TEST
• PROCEDURE

No Results Yet

NCT04942210 | ACTIVE_NOT_RECRUITING | PHASE2

568 participants

Study on an Investigational Yellow Fever Vaccine Compared With YF-VAX in Adults in the USA

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-07-01

Completion:

2022-06-24

Conditions

• Yellow Fever
• Healthy Volunteers

Interventions

• BIOLOGICAL

Results Available

NCT04932434 | COMPLETED | PHASE2

12 participants

Psilocybin Therapy for Depression and Anxiety in Parkinson's Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-08-15

Completion:

2024-12-31

Conditions

• Parkinson Disease
• Depression
• Anxiety

Interventions

• DRUG

Results Available

NCT04924075 | RECRUITING | PHASE2

355 participants

Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-08-12

Completion:

2029-12-27

Conditions

• Pheochromocytoma/Paraganglioma
• Pancreatic Neuroendocrine Tumor
• Von Hippel-Lindau Disease
• Advanced Gastrointestinal Stromal Tumor
• HIF-2α Mutated Cancers

Interventions

• DRUG

No Results Yet

NCT04905693 | ENROLLING_BY_INVITATION | PHASE3

1850 participants

Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2022-09-06

Completion:

2029-12-31

Conditions

• Idiopathic Pulmonary Fibrosis
• Interstitial Lung Disease
• Progressive Pulmonary Fibrosis

Interventions

• DRUG
• DEVICE

No Results Yet

NCT04892953 | RECRUITING | PHASE2

51 participants

Local Consolidative Therapy and Durvalumab for Oligoprogressive and Polyprogressive Stage III NSCLC After Chemoradiation and Anti-PD-L1 Therapy

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-07-07

Completion:

2029-09-30

Conditions

• Stage III Lung Cancer AJCC v8
• Stage III Lung Non-Small Cell Cancer AJCC v7
• Stage IIIA Lung Cancer AJCC v8
• Stage IIIA Lung Non-Small Cell Cancer AJCC v7
• Stage IIIB Lung Cancer AJCC v8
• Stage IIIB Lung Non-Small Cell Cancer AJCC v7
• Stage IIIC Lung Cancer AJCC v8

Interventions

• DRUG
• BIOLOGICAL
• PROCEDURE
• OTHER

No Results Yet

NCT04886531 | RECRUITING | PHASE2

30 participants

Trial of Pre-operative Neratinib and Endocrine Therapy With Trastuzumab in ER-Positive, HER-2 Positive Breast Cancers

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2022-07-21

Completion:

2026-12-22

Conditions

• Breast Cancer
• HER2-positive Breast Cancer
• ER Positive Breast Cancer
• PR-Positive Breast Cancer

Interventions

• DRUG

No Results Yet

NCT04875754 | COMPLETED | PHASE1/PHASE2

12 participants

A Study Evaluating the Safety, Tolerability, and Range of Biologically Active Doses of ICM-203 in Mild to Moderate Knee Osteoarthritis

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2022-03-17

Completion:

2026-02-20

Conditions

• Osteoarthritis, Knee

Interventions

• GENETIC
• DRUG

No Results Yet

NCT04873362 | ACTIVE_NOT_RECRUITING | PHASE3

1188 participants

A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-05-04

Completion:

2027-03-31

Conditions

• Breast Cancer

Interventions

• DRUG

No Results Yet

NCT04866810 | SUSPENDED | NA

24 participants

The Effect of Diet and Exercise on ImmuNotherapy and the Microbiome (EDEN)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2023-07-25

Completion:

2026-10-31

Conditions

• Melanoma

Interventions

• BEHAVIORAL

No Results Yet

NCT04838678 | RECRUITING | EARLY_PHASE1

100 participants

Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-07-18

Completion:

2026-12-31

Conditions

• Hypertension
• Obesity

Interventions

• DRUG

No Results Yet

NCT04823299 | RECRUITING | NA

556 participants

Randomized Controlled Trial- Ablation Strategy for Paroxysmal Atrial Fibrillation - Trigger and Substrate Guided Wide Area Radiofrequency Ablation Compared to Pulsed Field Ablation Pulmonary Vein Isolation

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2026-03-23

Completion:

2029-03-31

Conditions

• Atrial Fibrillation
• Catheter Ablation
• Radiofrequency Catheter Ablation

Interventions

• PROCEDURE

No Results Yet

NCT04820387 | ACTIVE_NOT_RECRUITING

94 participants

Assessment of Remote Vital Signs for Telemedicine Applications

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2021-04-20

Completion:

2027-09-30

Conditions

• Telemedicine
• Physiology

No Results Yet

NCT04804553 | RECRUITING | PHASE3

60 participants

Apremilast Pediatric Study in Children With Active Juvenile Psoriatic Arthritis

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2022-03-17

Completion:

2028-03-21

Conditions

• Active Juvenile Psoriatic Arthritis

Interventions

• DRUG

No Results Yet

NCT04802759 | RECRUITING | PHASE1/PHASE2

316 participants

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-06-22

Completion:

2029-05-30

Conditions

• Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer

Interventions

• DRUG

No Results Yet

NCT04795934 | ACTIVE_NOT_RECRUITING | NA

142 participants

Multicenter Single-Blind RCT of CTIF Versus LNF For Treatment of GERD in Patients Requiring Hiatal Hernia Repair

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-01-26

Completion:

2025-07-31

Conditions

• GERD
• Hiatal Hernia

Interventions

• PROCEDURE

No Results Yet

NCT04793360 | ACTIVE_NOT_RECRUITING

1500 participants

Molecular Assessment and Profiling of Liver Transplant Recipients

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2021-05-26

Completion:

2027-12-31

Conditions

• Liver Transplantation
• Biomarkers

Interventions

• DEVICE

No Results Yet

NCT04790344 | COMPLETED | NA

557 participants

LUX-Dx TRENDS Evaluates Diagnostics Sensors in Heart Failure Patients Receiving Boston Scientific's Investigational ICM System.

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-03-20

Completion:

2026-07-27

Conditions

• Heart Failure

Interventions

• DEVICE

No Results Yet

NCT04724499 | ACTIVE_NOT_RECRUITING | NA

30 participants

Improving Cognitive Function Through High-intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-07-14

Completion:

2026-06-09

Conditions

• Breast Cancer
• Chemotherapy Effect
• Exercise Therapy
• Cognitive Change

Interventions

• BEHAVIORAL
• OTHER

No Results Yet

NCT04700527 | RECRUITING | PHASE1/PHASE2

122 participants

The Effects of SCFA Supplementation in Subjects Receiving Abdominopelvic RT: A Randomized Controlled Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2023-12-15

Completion:

2027-04-21

Conditions

• Toxicity
• Radiation Toxicity

Interventions

• DRUG

No Results Yet

NCT04699838 | ACTIVE_NOT_RECRUITING | PHASE2

30 participants

Chemo-Immunotherapy Followed by Durvalumab and Ceralasertib in Treatment Naïve Patients With Extensive Stage Small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-04-20

Completion:

2027-01-31

Conditions

• Extensive Stage Small Cell Lung Cancer

Interventions

• DRUG

No Results Yet

NCT04691661 | ACTIVE_NOT_RECRUITING | PHASE2

43 participants

Safety, Tolerability, Pharmacokinetics and Efficacy Study of Radotinib in Parkinson's Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-09-09

Completion:

2026-09-02

Conditions

• Parkinson Disease

Interventions

• DRUG

No Results Yet

NCT04684524 | COMPLETED | PHASE3

62 participants

Dupilumab in Allergic Fungal Rhinosinusitis (AFRS)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-12-01

Completion:

2024-12-14

Conditions

• Allergic Fungal Rhinosinusitis

Interventions

• DRUG

Results Available

NCT04683653 | RECRUITING | PHASE1/PHASE2

100 participants

Study of Pelvic Hypofractionated Radiotherapy in Endometrial Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-01-15

Completion:

2026-08-20

Conditions

• Endometrial Cancer

Interventions

• RADIATION
• OTHER

No Results Yet

NCT04677049 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

59 participants

Study of Niacin in Glioblastoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-03-18

Completion:

2027-12-31

Conditions

• Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype

Interventions

• DRUG

No Results Yet

NCT04676594 | ACTIVE_NOT_RECRUITING

400 participants

Genentech Validation Tool for Pulmonary Fibrosis

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2020-10-04

Completion:

2027-08-31

Conditions

• Interstitial Lung Disease

No Results Yet

NCT04657991 | ACTIVE_NOT_RECRUITING | PHASE3

257 participants

A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-01-15

Completion:

2026-10-30

Conditions

• Melanoma

Interventions

• DRUG

No Results Yet

NCT04643015 | ACTIVE_NOT_RECRUITING

21 participants

New Ways of Doing Magnetic Resonance Imaging in Children and Adults

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2020-11-18

Completion:

2026-11-18

Conditions

• Pediatric Disorder
• Adult Disease

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT04635384 | ACTIVE_NOT_RECRUITING

307 participants

Assessment of Chimerism and Relapse Post Bone Marrow/Hematopoietic Cell Transplant (HCT) Using AlloHeme Test

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2021-06-30

Completion:

2026-10-15

Conditions

• Acute Myeloid Leukemia
• Acute Lymphoblastic Leukemia
• Myelodysplastic Syndrome

No Results Yet

NCT04633252 | RECRUITING | PHASE1/PHASE2

86 participants

A Phase I/II Study of PDS01ADC With Docetaxel and Abiraterone in Adults With Metastatic Castration Sensitive and PDS01ADC With Docetaxel in Castration Resistant Prostate Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-02-23

Completion:

2026-12-31

Conditions

• Cancer Of Prostate
• Prostate Neoplasms

Interventions

• DRUG

No Results Yet

NCT04628767 | RECRUITING | PHASE2/PHASE3

131 participants

Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-11-12

Completion:

2027-09-30

Conditions

• Renal Pelvis and Ureter Urothelial Carcinoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT04624906 | ACTIVE_NOT_RECRUITING | PHASE2

63 participants

Bendamustine, Rituximab and Acalabrutinib in Waldenstrom's Macroglobulinemia

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-03-02

Completion:

2025-12-31

Conditions

• Waldenstrom Macroglobulinemia

Interventions

• DRUG

No Results Yet

NCT04620707 | COMPLETED | NA

52 participants

RGS@Home: Personalized 24/7 Home Care Post-stroke

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-11-09

Completion:

2023-08-04

Conditions

• Stroke
• Hemiparesis
• Subacute Stroke
• Chronic Stroke

Interventions

• DEVICE
• BEHAVIORAL

No Results Yet

NCT04588922 | RECRUITING | PHASE1/PHASE2

160 participants

Study of SLS009 (Formerly GFH009) a Potent Highly Selective CDK9 Inhibitor in Patients With Hematologic Malignancies and High-Risk Newly Diagnosed AML

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-05-10

Completion:

2026-12-30

Conditions

• Hematologic Malignancies

Interventions

• DRUG

No Results Yet

NCT04586023 | ACTIVE_NOT_RECRUITING | PHASE3

751 participants

Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-03-24

Completion:

2025-09-05

Conditions

• Relapsing Multiple Sclerosis

Interventions

• DRUG

No Results Yet

NCT04544449 | ACTIVE_NOT_RECRUITING | PHASE3

985 participants

A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants With Primary Progressive Multiple Sclerosis

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-10-26

Completion:

2025-09-17

Conditions

• Multiple Sclerosis, Primary Progressive

Interventions

• DRUG

No Results Yet

NCT04537390 | RECRUITING | NA

100 participants

Anti-mullerian Hormone Levels in Healthy Females

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2016-07-19

Completion:

2030-12-01

Conditions

• Healthy

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT04524871 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

518 participants

A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-11-01

Completion:

2027-07-30

Conditions

• Advanced Liver Cancers

Interventions

• DRUG

No Results Yet

NCT04493060 | COMPLETED | PHASE2

22 participants

Niraparib and Dostarlimab for the Treatment of Germline or Somatic BRCA1/2 and PALB2 Mutated Metastatic Pancreatic Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-12-28

Completion:

2023-12-07

Conditions

• Metastatic Pancreatic Ductal Adenocarcinoma
• Stage IV Pancreatic Cancer AJCC v8

Interventions

• BIOLOGICAL
• DRUG

Results Available

NCT04487249 | COMPLETED | NA

47 participants

Trial of Vision Therapy for Intermittent Exotropia

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-10-01

Completion:

2026-04-30

Conditions

• Intermittent Exotropia

Interventions

• OTHER

No Results Yet