Clinical Trials

NCT07093489 | RECRUITING

11990 participants

Evaluation of Effectiveness and Safety of LC16m8 Mpox Vaccine in the Democratic Republic of Congo (DRC)

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-31

Start Date:

2025-12-03

Completion:

2027-08-01

Conditions

• Mpox (Monkeypox)
• Mpox

Interventions

• BIOLOGICAL

No Results Yet

NCT07080489 | RECRUITING | NA

444 participants

Exploring the Role of the Prefrontal Cortex in Decision-Making

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-03-04

Completion:

2027-12-31

Conditions

• Depressive Disorder, Major Depressive Disorder
• Healthy Volunteer
• Aging

Interventions

• DEVICE

No Results Yet

NCT07079475 | RECRUITING | PHASE1/PHASE2

220 participants

Study of Oral EGFR Inhibitor DZD6008 Combined With Sunvozertinib in Patients Who Have Advanced NSCLC With EGFR Mutations (TIAN-SHAN8)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-07-30

Completion:

2028-06-30

Conditions

• Non-Small Cell Lung Cancer

Interventions

• DRUG

No Results Yet

NCT07077161 | RECRUITING | PHASE2

34 participants

Cabozantinib Dose Skipping as an Alternative to Dose Reductions

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2026-01-26

Completion:

2027-09-01

Conditions

• Renal Cell Carcinoma (RCC)

Interventions

• DRUG

No Results Yet

NCT07076550 | TERMINATED | PHASE1

5 participants

A Phase 1-1b Study to Evaluate the Safety, Efficacy and Dosimetry of Study Drug A9-3408 in Subjects With Metastatic Melanoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-11-19

Completion:

2026-07-09

Conditions

• Melanoma Metastatic
• Uveal Melanoma, Metastatic
• Mucosal Melanoma

Interventions

• DRUG
• DIAGNOSTIC_TEST

No Results Yet

NCT07071519 | RECRUITING | PHASE3

120 participants

A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-07-28

Completion:

2034-07-31

Conditions

• Ulcerative Colitis

Interventions

• DRUG

No Results Yet

NCT07070661 | COMPLETED | NA

44 participants

Radial Pressure Wave Therapy With or Without Parameter Modulation for Carpal Tunnel Syndrome.

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-07-15

Completion:

2026-01-15

Conditions

• Carpal Tunnel Syndrome (CTS)

Interventions

• DEVICE

No Results Yet

NCT07070440 | RECRUITING | PHASE1/PHASE2

180 participants

DZD6008 Combination Therapy in Patients With Locally Advanced or Metastatic NSCLC With EGFR Mutation (TIAN-SHAN7)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-07-16

Completion:

2027-06-30

Conditions

• Non Small Cell Lung Cancer

Interventions

• DRUG

No Results Yet

NCT07067463 | RECRUITING | PHASE3

705 participants

A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2026-03-23

Completion:

2030-06-30

Conditions

• Multiple Sclerosis (MS) Primary Progressive

Interventions

• DRUG

No Results Yet

NCT07067151 | ENROLLING_BY_INVITATION

30 participants

Using Smartwatches to Monitor Smoking in Real-life Situations

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-31

Start Date:

2026-09-03

Completion:

2027-04-30

Conditions

• Smoking

No Results Yet

NCT07062315 | ENROLLING_BY_INVITATION | NA

90 participants

Impact of Chronotype-Based Time-Restricted Eating on Visceral Fat and Metabolic Health in Physically Inactive Adults With Central Obesity

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-07-31

Completion:

2026-10-31

Conditions

• Central Obesity
• Time Restricted Eating

Interventions

• BEHAVIORAL

No Results Yet

NCT07061977 | RECRUITING | PHASE3

336 participants

Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-11-05

Completion:

2030-12-31

Conditions

• Locally Advanced Cervical Adenocarcinoma
• Locally Advanced Cervical Adenosquamous Carcinoma
• Locally Advanced Cervical Squamous Cell Carcinoma
• Stage IIIA Cervical Cancer FIGO 2018
• Stage IIIB Cervical Cancer FIGO 2018
• Stage IIIC1 Cervical Cancer FIGO 2018
• Stage IIIC2 Cervical Cancer FIGO 2018
• Stage IVA Cervical Cancer FIGO 2018

Interventions

• PROCEDURE
• RADIATION
• DRUG
• BIOLOGICAL

No Results Yet

NCT07061964 | RECRUITING | PHASE2

111 participants

Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-11-25

Completion:

2027-07-31

Conditions

• Muscle Invasive Bladder Urothelial Carcinoma
• Stage II Bladder Cancer AJCC v8
• Stage IIIA Bladder Cancer AJCC v8

Interventions

• PROCEDURE
• BIOLOGICAL
• RADIATION
• OTHER

No Results Yet

NCT07057336 | COMPLETED | NA

90 participants

Evaluation of Post-Operative Pain Following the Use of Nano-Calcium Hydroxide

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2024-05-14

Completion:

2024-12-15

Conditions

• Chronic Apical Periodontitis

Interventions

• DRUG

No Results Yet

NCT07054190 | RECRUITING | PHASE2

120 participants

A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-09-09

Completion:

2027-07-31

Conditions

• Breast Cancer

Interventions

• DRUG

No Results Yet

NCT07053514 | NOT_YET_RECRUITING | NA

139 participants

Same-Day Antiretroviral Therapy as a Behavioral Design Intervention to Reduce Stigma in Key Affected Populations

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2027-10-31

Completion:

2028-10-31

Conditions

• Hiv

Interventions

• BEHAVIORAL

No Results Yet

NCT07045038 | COMPLETED | NA

60 participants

Blood Flow Restricted Resistance Exercises Versus Low Level Laser on Cardiac Functions in Patients With Chronic Heart Failure

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-07-20

Completion:

2026-04-20

Conditions

• Heart Failure NYHA Class II

Interventions

• DEVICE
• OTHER
• DRUG

No Results Yet

NCT07042295 | SUSPENDED | PHASE2

86 participants

Treatment With Amivantamab and Hyaluronidase or Cetuximab for Advanced Skin Cancer in People With a Weakened Immune System

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2026-03-23

Completion:

2029-02-28

Conditions

• Locally Recurrent Skin Squamous Cell Carcinoma
• Metastatic Skin Squamous Cell Carcinoma

Interventions

• DRUG
• PROCEDURE
• BIOLOGICAL

No Results Yet

NCT07041723 | RECRUITING | NA

6 participants

BiOfeedback, Online for Sibilant Treatment

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-07-30

Completion:

2027-07-31

Conditions

• Speech Sound Disorder

Interventions

• BEHAVIORAL

No Results Yet

NCT07041125 | COMPLETED

122 participants

Concomitant LAAC/AF Ablation (Watchman FLX Pro)

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-31

Start Date:

2025-06-01

Completion:

2026-06-30

Conditions

• PFA Ablation and LAAC Procedures

Interventions

• DEVICE

No Results Yet

NCT07030868 | TERMINATED | PHASE2

1 participants

A Study of LY3549492 in Adults With Obesity or Overweight With Type 2 Diabetes

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-06-19

Completion:

2025-07-29

Conditions

• Obesity
• Overweight
• Type 2 Diabetes

Interventions

• DRUG

Results Available

NCT07027826 | RECRUITING | NA

70 participants

The Esophageal String Test as a Diagnostic Screening Tool for Eosinophilic Esophagitis Among Africans With Dysphagia in Mali and the United States

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2026-09-03

Completion:

2027-08-31

Conditions

• Dysphagia
• Eosinophilic Esophagitis

Interventions

• DEVICE

No Results Yet

NCT07019649 | COMPLETED | NA

21 participants

Randomized Pilot Trial of AYUDA Program for Younger Latinx Adults With Type 2 Diabetes

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-07-25

Completion:

2026-06-09

Conditions

• Diabetes Mellitus, Type 2

Interventions

• BEHAVIORAL

No Results Yet

NCT07015034 | RECRUITING | NA

460 participants

Developing and Testing a Model to Identify Preventive Vision Loss Among Older Patients in General Practice

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2024-05-15

Completion:

2026-10-30

Conditions

• Vision Impairment and Blindness
• Glaucoma
• Age-Related Macular Degeneration
• Cataract
• Diabetic Retinopathy

Interventions

• OTHER

No Results Yet

NCT07013201 | RECRUITING | PHASE2

135 participants

A 16-week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream 20 mg/g in Adult Participants With Mild to Severe Palmoplantar Pustulosis

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-09-11

Completion:

2026-12-14

Conditions

• Palmoplantar Pustulosis

Interventions

• DRUG

No Results Yet

NCT07010302 | NOT_YET_RECRUITING | PHASE4

540 participants

Rituximab Versus Ravulizumab, Inebilizumab, Satralizumab, and Eculizumab in NMOSD

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2026-08-01

Completion:

2030-01-31

Conditions

• NMOSD

Interventions

• DRUG

No Results Yet

NCT07005297 | NOT_YET_RECRUITING

1000 participants

Clinical Genetics Branch Eligibility Screening Survey

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-31

Start Date:

2026-09-03

Completion:

2035-01-01

Conditions

• Melanoma
• Li-Fraumeni Syndrome
• Pulmonary Blastoma
• Chordoma
• Congenital Bone Marrow Failure Syndromes
• Costello Syndrome
• Fanconi Anemia
• CFC Syndrome (CFCS)
• Legius Syndrome
• RASopathies

No Results Yet

NCT07004699 | RECRUITING | NA

610 participants

Comparison of Two Ventilation Methods During Endoscopy of the Pharynx, Larynx and Oesophagus

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-07-11

Completion:

2027-07-01

Conditions

• Oxygen Inhalation Therapy Endoscopy

Interventions

• PROCEDURE

No Results Yet

NCT06995885 | ENROLLING_BY_INVITATION

30 participants

Development of an Interview-Informed Timeline Follow-Back (TLFB) for Opioid Use in the Era of Fentanyl

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-31

Start Date:

2026-09-03

Completion:

2027-05-31

Conditions

• Substance Use Disorders (SUDs)

No Results Yet

NCT06995651 | RECRUITING | PHASE1

15 participants

Dorzagliatin in Pancreatic Insufficient Cystic Fibrosis

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-10-21

Completion:

2027-07-31

Conditions

• Pancreatic Insufficiency
• Cystic Fibrosis-related Diabetes

Interventions

• DRUG

No Results Yet

NCT06995521 | RECRUITING | PHASE2

55 participants

Vorinostat for Graft-versus-host Disease (GVHD) Prevention in Non-Malignant Adolescent and Young Adults (AYA) Population

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2026-09-30

Completion:

2028-09-30

Conditions

• GVHD

Interventions

• DRUG

No Results Yet

NCT06991738 | NOT_YET_RECRUITING | PHASE1/PHASE2

18 participants

177Lu-DOTA-EB-TATE in Adult Patients With Metastatic, Radioactive Iodine Non-Responsive Oncocytic (Hurthle-Cell) Thyroid Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2026-09-03

Completion:

2032-07-01

Conditions

• Thyroid Cancer

Interventions

• DIAGNOSTIC_TEST
• OTHER
• DRUG

No Results Yet

NCT06991556 | ACTIVE_NOT_RECRUITING | PHASE2

167 participants

An Open-label Study of JSB462 (Luxdegalutamide) in Combination With Abiraterone in Adult Male Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-07-07

Completion:

2032-02-13

Conditions

• Metastatic Hormone-sensitive Prostate Cancer

Interventions

• DRUG

No Results Yet

NCT06990737 | WITHDRAWN | PHASE2

0 participants

Phase 2 Pragmatic Trial of Sentinel Lymph Node Biopsy (SLNB) in Patients With Clinically Node-Negative (cN0), High-Risk Cutaneous Squamous Cell Carcinoma (cSCC) of the Head and Neck

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-06-25

Completion:

2026-06-18

Conditions

• Cutaneous Squamous Cell Carcinoma of the Head and Neck
• Clinically Node-Negative (cN0)
• High-Risk Cutaneous Squamous Cell Carcinoma (cSCC) of the Head and Neck

Interventions

• PROCEDURE
• DRUG

No Results Yet

NCT06985641 | ACTIVE_NOT_RECRUITING | NA

119 participants

Khanya Ekhaya: A Home-Based Intervention

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2026-08-17

Completion:

2026-11-23

Conditions

• Mental Health
• Community Health Workers
• Training
• Global Health
• Burnout
• Well-being
• Natured-informed Therapy

Interventions

• BEHAVIORAL

No Results Yet

NCT06981923 | COMPLETED | NA

350 participants

Awake Video Stylet Airway Assessment and Evaluation of Tracheal Intubation With CMAC D-Blade Versus Video Stylet in Bariatric Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-05-10

Completion:

2026-02-10

Conditions

• Difficult Intubation in Obesity

Interventions

• DEVICE

No Results Yet

NCT06976190 | RECRUITING | PHASE3

446 participants

A Study of MRG003 in Combination With Pucotenlimab Versus Chemotherapy in the Treatment of Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-05-06

Completion:

2029-05-31

Conditions

• Recurrent or Metastatic Nasopharyngeal Carcinoma

Interventions

• DRUG

No Results Yet

NCT06974916 | RECRUITING | NA

100 participants

EMBRACE Tremor BiFUS

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-04-22

Completion:

2027-07-31

Conditions

• Essential Tremor

Interventions

• PROCEDURE
• OTHER

No Results Yet

NCT06968806 | RECRUITING | PHASE3

1346 participants

Study on Ketorolac for Improving Outcomes and Prognosis in Patients With Stanford Type A Aortic Dissection

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2025-10-27

Completion:

2027-09-01

Conditions

• Aortic Dissection
• Inflammation

Interventions

• DRUG

No Results Yet

NCT06966362 | RECRUITING | PHASE4

400 participants

Varenicline for Smoking Reduction in Veterans Not Ready To Quit

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2026-08-17

Completion:

2030-06-28

Conditions

• Veterans
• Tobacco Use Disorder
• Cigarette Smoking
• Tobacco Dependence

Interventions

• DRUG
• BEHAVIORAL

No Results Yet