Clinical Trials

NCT05471960 | RECRUITING

86 participants

Neuroplasticity in RBD

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-27

Start Date:

2023-04-21

Completion:

2027-07-31

Conditions

• REM Sleep Behavior Disorder

Interventions

• OTHER

No Results Yet

NCT05470348 | RECRUITING | PHASE1

36 participants

A Study of BL-B01D1 in Patients With Unresectable Locally Advanced or Metastatic Breast Cancer and Other Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-08-11

Completion:

2026-12-31

Conditions

• Breast Cancer
• Solid Tumor

Interventions

• DRUG

No Results Yet

NCT05461768 | RECRUITING | PHASE1

348 participants

A Study of BL-M07D1 in Patients With Locally Advanced or Metastatic HER2-Positive/Negative Breast Cancer and Other Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-08-09

Completion:

2026-12-31

Conditions

• Breast Cancer
• Locally Advanced or Metastatic Solid Tumor

Interventions

• DRUG

No Results Yet

NCT05459636 | ACTIVE_NOT_RECRUITING | NA

44 participants

Inspiratory Muscle Strength Training in Adults With Obesity

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2023-12-07

Completion:

2026-12-31

Conditions

• Obesity

Interventions

• DEVICE

No Results Yet

NCT05446376 | COMPLETED | PHASE2

19 participants

Contribution of PET/CT With Gallium 68 Citrate (68Ga-PET/CT) for the Diagnosis of Prosthetic Valve Infective Endocarditis

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2024-11-22

Completion:

2026-05-06

Conditions

• Infective Endocarditis

Interventions

• DRUG

No Results Yet

NCT05435300 | ACTIVE_NOT_RECRUITING

20 participants

Does tDCS Change Synaptic Density in the Brains of Patients With Schizophrenia

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-27

Start Date:

2021-09-17

Completion:

2026-09-30

Conditions

• Schizophrenia
• Schizoaffective

Interventions

• OTHER

No Results Yet

NCT05420064 | RECRUITING | NA

1000 participants

An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-12-01

Completion:

2027-05-31

Conditions

• BRCA1 Mutation
• POLD1 Gene Mutation
• CDKN2A Mutation
• BRCA2 Mutation
• POLE Gene Mutation
• APC Gene Mutation
• ATM Gene Mutation
• MLH1 Gene Mutation
• BARD1 Gene Mutation
• MSH2 Gene Mutation
• BRIP1 Gene Mutation
• MSH6 Gene Mutation
• CHEK2 Gene Mutation
• PMS2 Gene Mutation
• PALB2 Gene Mutation
• EPCAM Gene Mutation
• RAD51C Gene Mutation
• BMPR1A Gene Mutation
• RAD51D Gene Mutation
• SMAD4
• PTEN Gene Mutation
• GREM1

Interventions

• BEHAVIORAL

No Results Yet

NCT05409976 | ACTIVE_NOT_RECRUITING | NA

136 participants

The GORE® VIABAHN® FORTEGRA Venous Stent IVC Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-10-25

Completion:

2026-05-09

Conditions

• Venous Thromboses
• Venous Disease
• Venous Leg Ulcer
• Venous Stasis
• Venous Ulcer
• Venous Stenosis
• Venous Occlusion
• Vein Thrombosis
• Vein Occlusion
• Vein Disease

Interventions

• DEVICE

Results Available

NCT05391295 | COMPLETED

15 participants

Mapping Emotional Dynamics During Corticosteroid Treatment

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-27

Start Date:

2022-09-19

Completion:

2024-07-28

Conditions

• Emotions
• Corticosteroids

Interventions

• OTHER

No Results Yet

NCT05372614 | RECRUITING | PHASE1

58 participants

Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-10-05

Completion:

2028-07-17

Conditions

• Metastatic Malignant Solid Neoplasm
• Metastatic Pancreatic Adenocarcinoma
• Stage III Pancreatic Cancer AJCC v8
• Stage IV Pancreatic Cancer AJCC v8
• Unresectable Malignant Solid Neoplasm
• Unresectable Pancreatic Adenocarcinoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT05338970 | ACTIVE_NOT_RECRUITING | PHASE3

586 participants

HERTHENA-Lung02: A Study of Patritumab Deruxtecan Versus Platinum-based Chemotherapy in Metastatic or Locally Advanced EGFRm NSCLC After Failure of EGFR TKI Therapy

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-07-08

Completion:

2024-05-31

Conditions

• Nonsquamous Non-small Cell Lung Cancer
• EGFR L858R
• EGFR Exon 19 Deletion

Interventions

• DRUG

No Results Yet

NCT05314998 | RECRUITING | PHASE3

394 participants

Adjuvant Trial in Patients With Resected PDAC Randomized to Allocation of Oxaliplatin- or Gemcitabine-based Chemotherapy by Standard Clinical Criteria or by a Transcriptomic Treatment Specific Stratification Signature

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2026-08-17

Completion:

2033-04-01

Conditions

• Pancreatic Ductal Adenocarcinoma

Interventions

• DRUG

No Results Yet

NCT05310838 | COMPLETED | NA

28 participants

Optimizing Engagement in Services for First-Episode Psychosis

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-03-01

Completion:

2025-12-16

Conditions

• Engagement, Patient
• First Episode Psychosis

Interventions

• BEHAVIORAL

No Results Yet

NCT05288790 | RECRUITING | PHASE2

250 participants

Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2023-09-18

Completion:

2027-03-31

Conditions

• Microtia
• Dysbiosis
• Alcohol Drinking
• HIV Infections
• Cardiovascular Diseases

Interventions

• DIETARY_SUPPLEMENT

No Results Yet

NCT05262491 | RECRUITING | PHASE1

96 participants

A Study of BL-B01D1 in Patients With Locally Advanced or Metastatic Gastrointestinal Tumor and Other Solid Tumor

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-02-14

Completion:

2026-12-31

Conditions

• Gastrointestinal Tumor

Interventions

• DRUG

No Results Yet

NCT05257746 | RECRUITING

500 participants

Perioperative and Postoperative Evaluation of Rectal and Urogenital Function in Patients Undergoing Rectal Resection

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-27

Start Date:

2021-03-03

Completion:

2030-06-30

Conditions

• Rectal Surgery

Interventions

• PROCEDURE

No Results Yet

NCT05213572 | RECRUITING

200 participants

Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-27

Start Date:

2022-03-24

Completion:

2035-06-01

Conditions

• Mortality in Sickle Cell
• Sickle Cell Cardiopulmonary Complications
• Sickle Cell Organ Damage
• Sickle Cell Life Expectancy and Risk Factors for Early Death
• Sickle Cell Lung Disease and Sudden Death

No Results Yet

NCT05194982 | RECRUITING | PHASE1

570 participants

A Study of BL-B01D1 in Patients With Locally Advanced or Metastatic Solid Tumor

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2021-11-29

Completion:

2026-12-31

Conditions

• Locally Advanced or Metastatic Solid Tumor

Interventions

• DRUG

No Results Yet

NCT05181982 | RECRUITING

10000 participants

Evaluation of a Flexible and Integrative Psychiatric Care Model at the Pfalzklinikum (EVA_Pfalz)

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-27

Start Date:

2022-09-30

Completion:

2025-09-30

Conditions

• Mental Health Care

Interventions

• OTHER

No Results Yet

NCT05175105 | ACTIVE_NOT_RECRUITING | PHASE3

30 participants

A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Not Regularly Transfused, Followed by a 5-Year Extension Period

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-06-06

Completion:

2024-12-13

Conditions

• Pediatric Pyruvate Kinase Deficiency
• Pediatric Hemolytic Anemia

Interventions

• DRUG

No Results Yet

NCT05172752 | RECRUITING | NA

200 participants

A University-Community Partnership to Reduce Exposure to Disinfection Byproducts In Appalachia

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-02-25

Completion:

2026-10-31

Conditions

• Disinfection By-products

Interventions

• OTHER

No Results Yet

NCT05162742 | ACTIVE_NOT_RECRUITING | PHASE3

150 participants

Colchicine and Inflammation in Aortic Stenosis

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-12-22

Completion:

2026-12-31

Conditions

• Aortic Valve Disease
• Aortic Valve Stenosis
• Aortic Valve Calcification
• Inflammation
• Calcification
• Cardiovascular Diseases

Interventions

• DRUG

No Results Yet

NCT05153226 | ACTIVE_NOT_RECRUITING | PHASE3

640 participants

GvHD Prophylaxis in Unrelated Donor HCT: Randomized Trial Comparing PTCY Versus ATG

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-03-02

Completion:

2026-03-31

Conditions

• Graft Vs Host Disease
• Peripheral Blood Stem Cell Transplantation
• AML
• MDS
• MDS/MPN
• CMML

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT05150691 | RECRUITING | PHASE1/PHASE2

796 participants

A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-01-31

Completion:

2027-08-31

Conditions

• HER2-positive Advanced Solid Tumor

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT05145868 | ACTIVE_NOT_RECRUITING | NA

400 participants

Just-In-Time Intervention to Reduce Alcohol-Facilitated Intimate Partner Violence Perpetration

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2023-01-03

Completion:

2026-11-01

Conditions

• Alcohol Drinking
• Aggression
• Emotion Regulation

Interventions

• BEHAVIORAL
• OTHER

No Results Yet

NCT05144256 | ACTIVE_NOT_RECRUITING | PHASE3

49 participants

A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Regularly Transfused, Followed by a 5-Year Extension Period

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-06-08

Completion:

2024-05-03

Conditions

• Pediatric Pyruvate Kinase Deficiency
• Pediatric Hemolytic Anemia

Interventions

• DRUG

No Results Yet

NCT05138393 | RECRUITING | NA

90 participants

Scoliosis-specific Exercises for Mild Idiopathic Scoliosis

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-02-18

Completion:

2027-11-30

Conditions

• Idiopathic Scoliosis

Interventions

• OTHER

No Results Yet

NCT05132075 | ACTIVE_NOT_RECRUITING | PHASE3

95 participants

Study of JDQ443 in Comparison With Docetaxel in Participants With Locally Advanced or Metastatic KRAS G12C Mutant Non-small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-06-15

Completion:

2026-08-25

Conditions

• Non-Small Cell Lung Cancer

Interventions

• DRUG

No Results Yet

NCT05107635 | RECRUITING

500 participants

Inappropriate Sinus Tachycardia Registry

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-27

Start Date:

2022-03-01

Completion:

2027-01-31

Conditions

• Inappropriate Sinus Tachycardia
• Postural Tachycardia Syndrome

Interventions

• DEVICE

No Results Yet

NCT05107310 | ACTIVE_NOT_RECRUITING | NA

62 participants

The Spinal Navigation Trial - Surgical Navigation or Free Hand Technique in Spine Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-01-18

Completion:

2024-06-30

Conditions

• Scoliosis
• Kyphosis

Interventions

• PROCEDURE

No Results Yet

NCT05103345 | RECRUITING | PHASE1/PHASE2

70 participants

Study of SGN1 Administered Via Intratumoral Injection in Patients With Advanced Solid Tumor

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2023-04-19

Completion:

2027-12-31

Conditions

• Advanced Solid Tumor

Interventions

• DRUG

No Results Yet

NCT05099666 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

62 participants

Lurbinectedin + Doxorubicin In Leiomyosarcoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-02-04

Completion:

2026-12-31

Conditions

• Advanced Soft-tissue Sarcoma
• Metastatic Soft-tissue Sarcoma
• Advanced Leiomyosarcoma
• Leiomyosarcoma Metastatic

Interventions

• DRUG

No Results Yet

NCT05081128 | COMPLETED | NA

99 participants

Efficacy in iNPH Shunting (PENS) Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-05-18

Completion:

2026-02-24

Conditions

• Idiopathic Normal Pressure Hydrocephalus (INPH)

Interventions

• DEVICE

Results Available

NCT05077904 | RECRUITING | PHASE3

350 participants

A Study to Test the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2021-12-07

Completion:

2026-09-30

Conditions

• Stereotypical Prolonged Seizures

Interventions

• DRUG
• OTHER

No Results Yet

NCT05063162 | ACTIVE_NOT_RECRUITING | PHASE3

113 participants

A Study to Evaluate the Efficacy and Safety of Rozanolixizumab in Adult Participants With Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Disease (MOGAD)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-02-02

Completion:

2027-05-06

Conditions

• Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD)

Interventions

• DRUG
• OTHER

No Results Yet

NCT05038150 | RECRUITING | PHASE1/PHASE2

70 participants

Study of SGN1 in Patients With Advanced Solid Tumor

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2023-01-16

Completion:

2028-01-18

Conditions

• Advanced Solid Tumor

Interventions

• DRUG

No Results Yet

NCT05017532 | COMPLETED | NA

15 participants

Cognitive Remediation for Social Cognition in Schizophrenia and Related Disorders

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2022-01-06

Completion:

2025-02-14

Conditions

• Psychosis
• Schizophrenia
• Cognitive Impairment

Interventions

• BEHAVIORAL

No Results Yet

NCT05012111 | RECRUITING

1000 participants

Natural History of Acquired and Inherited Bone Marrow Failure Syndromes

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-27

Start Date:

2021-10-25

Completion:

2041-02-04

Conditions

• Severe Aplastic Anemia
• Telomere Biology Disorders
• Inherited Bone Marrow Failure Syndromes

No Results Yet

NCT04962061 | COMPLETED | NA

159 participants

A Combined Multidomain Intervention to Prevent Cognitive Decline Associated With Cardiovascular Risk Factors.

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-27

Start Date:

2021-09-01

Completion:

2026-02-06

Conditions

• Aging
• Cardiovascular Risk Factor

Interventions

• OTHER

No Results Yet

NCT04947605 | ACTIVE_NOT_RECRUITING

524 participants

Epidemiological Landscape of Cervical Cancer in Latin America

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-27

Start Date:

2021-11-04

Completion:

2023-03-31

Conditions

• Uterine Cervical Neoplasms

No Results Yet