Clinical Trials Updated in 2026

NCT04943445 | COMPLETED | PHASE2

43 participants

Study of a Pembrolizumab-based Organ Preservation Strategy for Locally Advanced Larynx Cancers

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2022-02-22
Completion:: 2023-08-22

Conditions

Squamous Cell Carcinoma of Larynx

Interventions

DRUG
RADIATION

No Results Yet

NCT04925479 | RECRUITING | PHASE1/PHASE2

34 participants

Study to Determine the Dose and Safety of Asciminib in Pediatric Patients With Chronic Myeloid Leukemia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2021-12-27
Completion:: 2027-09-21

Conditions

Myeloid Leukemia, Philadelphia Positive

Interventions

DRUG

No Results Yet

NCT04904146 | RECRUITING

120 participants

Predictive and Prognostic Biomarkers in Patients With Mycosis Fungoides and Sézary Syndrome.

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-27
Start Date:: 2021-04-02
Completion:: 2027-04-30

Conditions

Mycosis Fungoides
Sezary Syndrome

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04878094 | ACTIVE_NOT_RECRUITING | PHASE3

155 participants

A Study of Intra-operative Imaging in Women With Ovarian Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2021-05-03
Completion:: 2027-05-03

Conditions

Ovarian Cancer
Ovarian Carcinoma

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04862117 | ACTIVE_NOT_RECRUITING | NA

14 participants

Long Term Extension of Safety and Efficacy of Vagus Nerve Stimulator in Patients With Rheumatoid Arthritis (RA)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2018-07-28
Completion:: 2026-12-08

Conditions

Rheumatoid Arthritis

Interventions

DEVICE

No Results Yet

NCT04842552 | COMPLETED | PHASE3

228 participants

Effect of Hydralazine on Alzheimer's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2021-08-02
Completion:: 2026-03-05

Conditions

Alzheimer Disease

Interventions

DRUG

No Results Yet

NCT04805437 | RECRUITING | NA

170 participants

Brace Treatment for Idiopathic Scoliosis; PReventing Idiopathic SCOliosis PROgression

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2021-04-30
Completion:: 2027-09-30

Conditions

Idiopathic Scoliosis

Interventions

DEVICE

No Results Yet

NCT04801329 | COMPLETED

110 participants

Korean Post-marketing Surveillance Vyndamax® Capsules for the Treatment of Transthyretin Amyloid Cardiomyopathy

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-27
Start Date:: 2021-06-29
Completion:: 2026-04-21

Conditions

ATTR-CM (Transthyretin Amyloid Cardiomyopathy)

Interventions

DRUG

No Results Yet

NCT04794972 | RECRUITING | PHASE1

60 participants

A Study of GNC-039, a Tetra-specific Antibody, in Participants With Relapsed/Refractory or Metastatic Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2021-04-14
Completion:: 2026-12-31

Conditions

Recurrent Glioma
Solid Tumor

Interventions

DRUG

No Results Yet

NCT04770779 | ACTIVE_NOT_RECRUITING | PHASE3

258 participants

A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-TDT)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2021-11-30
Completion:: 2024-04-11

Conditions

Transfusion-dependent Alpha-Thalassemia
Transfusion-dependent Beta-Thalassemia

Interventions

DRUG

Results Available

NCT04770753 | ACTIVE_NOT_RECRUITING | PHASE3

194 participants

A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Non-Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-NTDT)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2021-12-20
Completion:: 2023-11-13

Conditions

Non-Transfusion-dependent Alpha-Thalassemia
Non-Transfusion-dependent Beta-Thalassemia

Interventions

DRUG

Results Available

NCT04751370 | ACTIVE_NOT_RECRUITING | PHASE2

31 participants

Testing Nivolumab and Ipilimumab With Short-Course Radiation in Locally Advanced Rectal Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2022-02-08
Completion:: 2026-12-31

Conditions

Locally Advanced Rectal Adenocarcinoma
Stage II Rectal Cancer AJCC v8
Stage III Rectal Cancer AJCC v8

Interventions

PROCEDURE
BIOLOGICAL
RADIATION

No Results Yet

NCT04729959 | ACTIVE_NOT_RECRUITING | PHASE2

61 participants

Testing the Addition of the Immune Therapy Drugs, Tocilizumab and Atezolizumab, to Radiation Therapy for Recurrent Glioblastoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2022-03-11
Completion:: 2025-06-15

Conditions

Diffuse Astrocytoma, IDH-Wildtype
Recurrent Glioblastoma

Interventions

BIOLOGICAL
PROCEDURE
RADIATION

Results Available

NCT04704661 | ACTIVE_NOT_RECRUITING | PHASE1

51 participants

Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2021-08-09
Completion:: 2027-03-31

Conditions

Advanced Breast Carcinoma
Advanced Colon Carcinoma
Advanced Colorectal Carcinoma
Advanced Endometrial Carcinoma
Advanced Gastric Carcinoma
Advanced Gastroesophageal Junction Adenocarcinoma
Advanced Malignant Solid Neoplasm
Advanced Salivary Gland Carcinoma
Anatomic Stage III Breast Cancer AJCC v8
Anatomic Stage IV Breast Cancer AJCC v8
Clinical Stage III Gastric Cancer AJCC v8
Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
Clinical Stage IV Gastric Cancer AJCC v8
Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
HER2-Positive Breast Carcinoma
Malignant Hepatobiliary Neoplasm
Metastatic Breast Carcinoma
Metastatic Colon Carcinoma
Metastatic Colorectal Carcinoma
Metastatic Endometrial Carcinoma
Metastatic Gastric Carcinoma
Metastatic Gastroesophageal Junction Adenocarcinoma
Metastatic Malignant Solid Neoplasm
Metastatic Salivary Gland Carcinoma
Stage III Colon Cancer AJCC v8
Stage III Colorectal Cancer AJCC v8
Stage III Major Salivary Gland Cancer AJCC v8
Stage III Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8
Stage IV Colon Cancer AJCC v8
Stage IV Colorectal Cancer AJCC v8
Stage IV Major Salivary Gland Cancer AJCC v8
Stage IV Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8
Unresectable Breast Carcinoma
Unresectable Colon Carcinoma
Unresectable Colorectal Carcinoma
Unresectable Endometrial Carcinoma
Unresectable Gastric Carcinoma
Unresectable Gastroesophageal Junction Adenocarcinoma
Unresectable Malignant Solid Neoplasm
Unresectable Salivary Gland Carcinoma

Interventions

PROCEDURE
DRUG
BIOLOGICAL

No Results Yet

NCT04696731 | ACTIVE_NOT_RECRUITING | PHASE1

120 participants

Safety and Efficacy of ALLO-316 in Subjects With Advanced or Metastatic Clear Cell Renal Cell Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2021-02-24
Completion:: 2030-01-31

Conditions

Advanced/Metastatic Clear Cell Renal Cell Carcinoma

Interventions

GENETIC
BIOLOGICAL
DRUG

No Results Yet

NCT04692675 | RECRUITING | NA

508 participants

Multiparametric Magnetic Resonance Imaging of the Prostate to Assess Disease Progression and Genomics in Patients Undergoing Active Surveillance for Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2022-11-18
Completion:: 2029-09-01

Conditions

Prostate Cancer

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04675749 | RECRUITING

200 participants

Quality of Life in Women With X-linked Adrenoleukodystrophy

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-27
Start Date:: 2019-12-01
Completion:: 2028-01-01

Conditions

X-linked Adrenoleukodystrophy

No Results Yet

NCT04669886 | RECRUITING

150 participants

Serum Endotoxin Assay to Predict the Development of Postoperative Infectious Complications and Systemic Inflammatory Response Following Percutaneous Nephrolithotomy.

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-27
Start Date:: 2023-11-01
Completion:: 2027-03-30

Conditions

Nephrolithiasis
Urosepsis

No Results Yet

NCT04669860 | SUSPENDED

90 participants

Evaluating the Bacterial and Fungal Microbiome in Patients With Calcium Oxalate Urolithiasis and Renal Cell Carcinoma

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-27
Start Date:: 2021-02-24
Completion:: 2028-09-01

Conditions

Calcium Oxalate Urolithiasis
Renal Cell Carcinoma

No Results Yet

NCT04633239 | RECRUITING | PHASE1

42 participants

Testing the Addition of Abemaciclib to Olaparib for Women With Recurrent Ovarian Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2021-07-02
Completion:: 2026-11-01

Conditions

Recurrent Ovarian High Grade Serous Adenocarcinoma
Recurrent Platinum-Resistant Ovarian Carcinoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT04599946 | ACTIVE_NOT_RECRUITING | NA

2132 participants

Goat Infant Formula Feeding and Eczema (the GIraFFE Study)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2021-01-08
Completion:: 2024-08-28

Conditions

Dermatitis, Atopic
Eczema, Infantile
Infant Development
Child Development

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT04589468 | RECRUITING | NA

51 participants

Researching the Effect of Exercise on Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2026-10-30
Completion:: 2028-02-13

Conditions

Breast Cancer
Prostate Cancer
Colorectal Cancer
Stage I Breast Cancer
Stage II Breast Cancer
Stage III Breast Cancer
Stage I Prostate Cancer
Stage II Prostate Cancer
Stage III Prostate Cancer
Stage I Colorectal Cancer
Stage II Colorectal Cancer
Stage III Colorectal Cancer

Interventions

OTHER

No Results Yet

NCT04569448 | RECRUITING | PHASE3

58 participants

Brexpiprazole Treatment for Bipolar I Depression

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2021-05-10
Completion:: 2030-09-30

Conditions

Bipolar Depression

Interventions

DRUG

No Results Yet

NCT04549116 | COMPLETED | PHASE3

688 participants

Subcutaneous Progesterone in Frozen- Thawed Single Euploid Blastocyst Transfer.

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2022-10-12
Completion:: 2026-01-20

Conditions

Infertility

Interventions

DRUG

No Results Yet

NCT04540211 | COMPLETED | PHASE3

461 participants

A Study of Atezolizumab Plus Tiragolumab in Combination With Paclitaxel and Cisplatin Compared With Paclitaxel and Cisplatin as First-Line Treatment in Participants With Unresectable Locally Advanced, Unresectable Recurrent, or Metastatic Esophageal Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2020-10-30
Completion:: 2023-02-13

Conditions

Esophageal Cancer

Interventions

DRUG

Results Available

NCT04506151 | COMPLETED | NA

144 participants

Sleep Optimization to Improve Glycemic Control in Adults With Type 1 Diabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2021-01-19
Completion:: 2024-12-21

Conditions

Type 1 Diabetes

Interventions

BEHAVIORAL

Results Available

NCT04501419 | RECRUITING | NA

600 participants

Tablet-based Mobile Health Ultrasound for Point-of-care Breast Cancer Diagnosis in Nigeria

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2019-10-05
Completion:: 2027-06-30

Conditions

Breast Cancer

Interventions

PROCEDURE
OTHER

No Results Yet

NCT04464200 | ACTIVE_NOT_RECRUITING | PHASE1

30 participants

19(T2)28z1xx Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Cancers

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2020-07-06
Completion:: 2027-07-31

Conditions

Diffuse Large B Cell Lymphoma
Primary Mediastinal Large B Cell Lymphoma
Transformed Follicular Lymphoma to Diffuse Large B Cell Lymphoma
Chronic Lymphocytic Leukemia
Indolent Non-Hodgkin Lymphoma
Marginal Zone Lymphoma
Waldenstrom Macroglobulinemia
Burkitt's Lymphoma
Primary CNS Lymphoma

Interventions

DRUG

No Results Yet

NCT04437225 | ACTIVE_NOT_RECRUITING | NA

15 participants

Renal Metabolism of Glycolate to Oxalate

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2020-03-12
Completion:: 2028-12-01

Conditions

Healthy

Interventions

DIETARY_SUPPLEMENT
OTHER

No Results Yet

NCT04426461 | COMPLETED | NA

260 participants

Approach-Avoidance, Computational Framework for Predicting Behavioral Therapy Outcome (AAC-BeT)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2020-09-11
Completion:: 2025-12-06

Conditions

Anxiety
Depression

Interventions

BEHAVIORAL

No Results Yet

NCT04380831 | ACTIVE_NOT_RECRUITING | EARLY_PHASE1

15 participants

TBI Using IMRT and Cyclophosphamide Prior to Stem Cell Transplant for the Treatment of Severe Systemic Sclerosis

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2022-02-24
Completion:: 2026-12-22

Conditions

Systemic Scleroderma

Interventions

PROCEDURE
DRUG
RADIATION

No Results Yet

NCT04352166 | COMPLETED | PHASE2

33 participants

Extended-Release Buprenorphine vs. Sublingual Buprenorphine for the Treatment of Opioid Use Disorder

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2020-12-15
Completion:: 2023-08-08

Conditions

Opioid-use Disorder

Interventions

DRUG

Results Available

NCT04318717 | RECRUITING | PHASE2

20 participants

Pembrolizumab and Hypofractionated Radiation Therapy for the Treatment of Mucosal Melanoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2020-05-29
Completion:: 2030-07-31

Conditions

Mucosal Melanoma of the Head and Neck

Interventions

DRUG
RADIATION

No Results Yet

NCT04303169 | COMPLETED | PHASE1/PHASE2

146 participants

Substudy 02C: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Stage III Melanoma Who Are Candidates for Neoadjuvant Therapy (MK-3475-02C/KEYMAKER-U02)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2020-06-26
Completion:: 2025-09-24

Conditions

Melanoma

Interventions

BIOLOGICAL
DRUG

Results Available

NCT04288089 | ACTIVE_NOT_RECRUITING | PHASE1

31 participants

A Study of H3B-6545 in Combination With Palbociclib in Women With Advanced or Metastatic Estrogen Receptor-Positive Human Epidermal Growth Factor Receptor-2 (HER2)-Negative Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2020-04-01
Completion:: 2022-09-16

Conditions

Receptors, Estrogen
Genes, Erbb-2
Breast Neoplasms

Interventions

DRUG

Results Available

NCT04278690 | TERMINATED | NA

36 participants

Supporting Safe Use of Medications by Parents After Infant Discharge From the Neonatal Intensive Care Unit

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2021-03-10
Completion:: 2026-01-09

Conditions

Medication Administered in Error

Interventions

OTHER

No Results Yet

NCT04261088 | ACTIVE_NOT_RECRUITING

25 participants

Assisted Suicide in Switzerland

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-27
Start Date:: 2020-02-03
Completion:: 2027-01-31

Conditions

Assisted Suicide

No Results Yet

NCT04232917 | RECRUITING | PHASE4

284 participants

Study of 2LPAPI® on the Clearance of Genital HR-HPV Infections.

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2020-10-17
Completion:: 2027-10-30

Conditions

Human Papilloma Virus

Interventions

DRUG

No Results Yet

NCT04222413 | RECRUITING | PHASE1

116 participants

Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2020-10-27
Completion:: 2027-12-31

Conditions

Advanced Solid Tumors
Metastatic Pancreatic Cancer
Pediatric Solid Tumor
Advanced Breast Cancer
Malignant Peripheral Nerve Sheath Tumor
Colorectal Neoplasms

Interventions

DRUG

No Results Yet

NCT04222335 | COMPLETED | NA

47 participants

Understanding and Overcoming the Early Adaptive Resistance to EGFR Tyrosine-kinase Inhibitors in Lung Cancer Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-27
Start Date:: 2021-03-26
Completion:: 2026-04-21

Conditions

Lung Cancer, Nonsmall Cell

Interventions

OTHER

No Results Yet