Clinical Trials

NCT05948943 | RECRUITING | PHASE2/PHASE3

232 participants

Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation.

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-11-24

Completion:

2028-05-31

Conditions

• Lymphatic Malformations

Interventions

• DRUG

No Results Yet

NCT05916417 | ACTIVE_NOT_RECRUITING | NA

60 participants

TMS-fNIRS Personalized Dosing

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2024-01-19

Completion:

2026-07-28

Conditions

• Post Traumatic Stress Disorder
• Traumatic Brain Injury

Interventions

• DEVICE

No Results Yet

NCT05902169 | RECRUITING | PHASE3

560 participants

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2024-01-29

Completion:

2028-01-28

Conditions

• Glioblastoma
• Recurrent Glioblastoma
• GBM

Interventions

• DEVICE
• DRUG

No Results Yet

NCT05891496 | COMPLETED | PHASE3

23 participants

A Research Study Looking at the Effect of Semaglutide on the Immune System and Other Biological Processes in People With Alzheimer's Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-06-20

Completion:

2024-08-19

Conditions

• Alzheimers Disease

Interventions

• DRUG

Results Available

NCT05878730 | RECRUITING

60 participants

Melatonin and Response to Lithium

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-18

Start Date:

2023-07-26

Completion:

2026-12-31

Conditions

• Bipolar Disorder I

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT05863195 | RECRUITING | PHASE3

408 participants

Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-10-19

Completion:

2029-06-30

Conditions

• Metastatic Colorectal Carcinoma
• Metastatic Malignant Neoplasm in the Liver
• Stage IV Colorectal Cancer AJCC v8
• Unresectable Colorectal Carcinoma

Interventions

• BIOLOGICAL
• PROCEDURE
• DRUG

No Results Yet

NCT05853458 | TERMINATED | PHASE4

76 participants

Evaluation of HU-resistance in Adult Patients With Polycythemia Vera Who Meet PV-AIM Predictors

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-07-28

Completion:

2026-02-26

Conditions

• Polycythemia Vera

Interventions

• DRUG

No Results Yet

NCT05831358 | ACTIVE_NOT_RECRUITING | NA

201 participants

Early Detection of Multiple Myeloma to Fight Cancer Disparities: A Screening and Patient Navigation Program

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-06-16

Completion:

2024-12-31

Conditions

• Multiple Myeloma
• Monoclonal Gammopathy of Undetermined Significance
• Smoldering Multiple Myeloma

Interventions

• OTHER

No Results Yet

NCT05821309 | RECRUITING | PHASE4

65 participants

Evaluation of Fecal Microbiome Changes After Antegrade Continence Enema Placement and Initiation of Bowel Flush Regimen

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-06-08

Completion:

2027-07-31

Conditions

• Constipation

Interventions

• DRUG

No Results Yet

NCT05815069 | COMPLETED | NA

20 participants

[18F]AlF-NOTA-pentixather PET/CT in Patients With Suspected Primary Hyperaldosteronism

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-01-07

Completion:

2024-01-30

Conditions

• Primary Hyperaldosteronism
• Aldosterone-Producing Adenoma

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT05801224 | RECRUITING | NA

70 participants

Vascular ARDS Recruitment After Inhaled Nitric Oxide

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2026-07-10

Completion:

2028-12-31

Conditions

• Acute Respiratory Distress Syndrome
• Ventilation Perfusion Mismatch

Interventions

• DEVICE

No Results Yet

NCT05781243 | COMPLETED | PHASE4

812 participants

Normal Saline Versus Lactated Ringer's Solution for Acute Pancreatitis Resuscitation

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-06-19

Completion:

2024-08-30

Conditions

• Acute Pancreatitis

Interventions

• DRUG

No Results Yet

NCT05773066 | COMPLETED | NA

220 participants

A Study of Belotero® Intense Lidocaine for Lip Augmentation

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-03-03

Completion:

2023-10-16

Conditions

• Lip Augmentation

Interventions

• DEVICE

Results Available

NCT05753930 | RECRUITING | PHASE2

10 participants

Imlifidase Prior to Kidney Transplant in Highly Sensitised Children

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-06-02

Completion:

2027-02-28

Conditions

• Kidney Transplantation in Highly Sensitized Patients

Interventions

• DRUG

No Results Yet

NCT05747534 | COMPLETED | PHASE2

107 participants

AT1001 for the Treatment of Long COVID

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-05-31

Completion:

2026-06-18

Conditions

• Long COVID
• Long COVID-19
• Post Acute COVID-19 Syndrome
• Post Acute Sequelae of COVID-19

Interventions

• DRUG

No Results Yet

NCT05736848 | ACTIVE_NOT_RECRUITING

200 participants

A Retrospective Assessment of OviTex PRS (OviTex)

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-18

Start Date:

2022-09-27

Completion:

2026-08-30

Conditions

• Reconstructive Surgical Procedures

Interventions

• DEVICE

No Results Yet

NCT05719441 | RECRUITING | PHASE2

48 participants

A Clinical Trial of Combination HIV-Specific Broadly Neutralizing Monoclonal Antibodies Combined With ART Initiation During Acute HIV Infection to Induce HIV Remission

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2024-08-19

Completion:

2028-04-06

Conditions

• Acute HIV Infection

Interventions

• BIOLOGICAL
• OTHER
• DRUG

No Results Yet

NCT05701917 | RECRUITING | NA

300 participants

DEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombosis

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-01-06

Completion:

2028-01-31

Conditions

• Venous Thromboembolism
• Deep Venous Thrombosis
• Post-Thrombotic Syndrome

Interventions

• DEVICE
• DRUG

No Results Yet

NCT05701215 | COMPLETED | PHASE2

10 participants

Venetoclax After TKI to Target Persisting Stem Cells in CML

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-08-31

Completion:

2026-05-31

Conditions

• Chronic Myeloid Leukemia

Interventions

• DRUG

No Results Yet

NCT05701176 | RECRUITING | NA

15 participants

A Clinical Imaging Study of the Changes in [18F]F-AraG Uptake Following Anti-PD-1 Therapy in Non-small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2022-11-03

Completion:

2027-01-31

Conditions

• Advanced Stage Non-small Cell Lung Cancer

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT05690724 | COMPLETED | NA

100 participants

Exploratory Trial in Healthy Adults With Mild Cognitive Impairment,16-week Intervention With Mitocholine™

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-01-09

Completion:

2024-08-16

Conditions

• Mild Cognitive Impairment

Interventions

• DIETARY_SUPPLEMENT

No Results Yet

NCT05684796 | COMPLETED | NA

100 participants

Comparison of Two Pulmonary Embolism Treatments

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-11-27

Completion:

2025-06-12

Conditions

• Pulmonary Embolism Acute

Interventions

• DRUG
• DEVICE

Results Available

NCT05670496 | RECRUITING

600 participants

Collection of Clinical Data and Specimens for Research in Hearing, Balance, Taste, Smell, Voice, Speech, and Language Disorders.

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-18

Start Date:

2023-03-08

Completion:

2027-08-01

Conditions

• Hearing Loss
• Deafness

No Results Yet

NCT05665595 | TERMINATED | PHASE3

1594 participants

A Study of Adjuvant Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab for Resected High-Risk Melanoma in Participants With High-Risk Stage II-IV Melanoma (MK-7684A-010/KEYVIBE-010)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-01-19

Completion:

2024-03-06

Conditions

• Melanoma

Interventions

• BIOLOGICAL

Results Available

NCT05657405 | RECRUITING

1250 participants

Observational Study of Advanced Data Analytics in Genetic Conditions

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-18

Start Date:

2026-07-29

Completion:

2032-12-31

Conditions

• Genetic Conditions

No Results Yet

NCT05657106 | ACTIVE_NOT_RECRUITING | NA

752 participants

Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-03-06

Completion:

2027-05-31

Conditions

• Opioid-Related Disorders
• Hepatitis C (HCV)
• Human Immunodeficiency Virus (HIV)
• Drug Overdose
• Substance Abuse
• Intravenous Drug Usage
• Opiate Substitution Treatment
• Sexually Transmitted Diseases

Interventions

• BEHAVIORAL

No Results Yet

NCT05653193 | ACTIVE_NOT_RECRUITING | PHASE2

50 participants

Interferon-gamma as Adjunctive Therapy in Chronic Pulmonary Aspergillosis: a Randomised Feasibility Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2024-05-17

Completion:

2026-11-30

Conditions

• Chronic Pulmonary Aspergillosis
• Aspergillosis

Interventions

• DRUG

No Results Yet

NCT05651932 | RECRUITING | PHASE1

165 participants

A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-02-22

Completion:

2027-12-31

Conditions

• Multiple Myeloma
• Myeloma
• Myeloma Multiple

Interventions

• DRUG

No Results Yet

NCT05645328 | ACTIVE_NOT_RECRUITING | NA

31 participants

Implementation of a Health System Intervention to Improve Quality of Cancer Care for Rural Patients

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-01-20

Completion:

2026-12-31

Conditions

• Cancer

Interventions

• OTHER

No Results Yet

NCT05621668 | ACTIVE_NOT_RECRUITING | PHASE1

5 participants

A First-In-Human Phase 1 Trial of T-Cell Membrane-Anchored Tumor Targeted Il12 (Attil12)- T-Cell Therapy in Subjects With Advanced/Metastatic Soft Tissue and Bone Sarcoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-09-08

Completion:

2027-09-30

Conditions

• Soft Tissue Sarcoma
• Bone Sarcoma

Interventions

• DRUG

No Results Yet

NCT05604534 | RECRUITING

200 participants

Assessing and Improving Quantitative Magnetic Resonance Imaging Metrics in Human Subjects

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-18

Start Date:

2023-02-02

Completion:

2041-03-31

Conditions

• Normal Physiology

No Results Yet

NCT05589714 | RECRUITING

1500 participants

Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-18

Start Date:

2023-05-11

Completion:

2029-12-15

Conditions

• Inherited Retinal Degeneration
• Retinitis Pigmentosa

No Results Yet

NCT05587023 | COMPLETED | NA

62 participants

Effect of Ultrasound-guided Left Stellate Ganglion Block on Rapid Recovery of Patients Undergoing Cardiac Valve Replacement and Its Mechanism

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2022-10-16

Completion:

2023-12-30

Conditions

• Stellate Ganglion Block
• Heart Valve Replacement (Mechanical or Biological With AF)

Interventions

• PROCEDURE

No Results Yet

NCT05586581 | RECRUITING | PHASE1/PHASE2

70 participants

SV2A & TSPO PET Imaging Measures to Reveal Mechanisms of HIV Neuropathogenesis During Antiretroviral Therapy

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-05-17

Completion:

2028-12-31

Conditions

• HIV Associated Neurocognitive Disorder
• HIV Dementia
• HIV Encephalitis
• Healthy

Interventions

• DRUG

No Results Yet

NCT05558514 | COMPLETED | NA

24 participants

Place-based Cochlear Implant Mapping

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-06-07

Completion:

2026-06-24

Conditions

• Hearing Loss, Sensorineural
• Cochlear Implants

Interventions

• OTHER

No Results Yet

NCT05541276 | RECRUITING | PHASE3

676 participants

MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2025-01-21

Completion:

2027-03-01

Conditions

• Emergence Delirium

Interventions

• DRUG

No Results Yet

NCT05521854 | COMPLETED | NA

62 participants

Contingency Management for Drug Use: Does Age Matter?

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-05-01

Completion:

2026-05-26

Conditions

• Opioid Use Disorder
• Methamphetamine Abuse
• Cocaine Use Disorder

Interventions

• BEHAVIORAL

No Results Yet

NCT05471128 | ACTIVE_NOT_RECRUITING

29 participants

MRI Fusion Biopsy vs. Micro-Ultrasound Guided Biopsy

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-18

Start Date:

2023-01-27

Completion:

2025-05-01

Conditions

• Prostate Cancer

Interventions

• PROCEDURE

No Results Yet

NCT05470504 | RECRUITING | PHASE2

25 participants

Study of Growth Hormone Inhibition Using Pegvisomant in Severe Insulin Resistance

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2023-01-23

Completion:

2028-01-30

Conditions

• Insulin Receptor Mutation
• Partial Lipodystrophy

Interventions

• DRUG

No Results Yet

NCT05435014 | TERMINATED | PHASE1/PHASE2

2 participants

T-ACE Oil by TAE/TACE in Patients With Hepatocellular Carcinoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-18

Start Date:

2022-09-13

Completion:

2026-06-15

Conditions

• Hepatocellular Carcinoma

Interventions

• DRUG

No Results Yet