Clinical Trials

NCT04305041 | COMPLETED | PHASE1/PHASE2

100 participants

Substudy 02A: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents in Participants With Programmed Cell-death 1 (PD-1) Refractory Melanoma (MK-3475-02A/KEYMAKER-U02)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2020-06-26
Completion:: 2025-08-25

Conditions

Melanoma

Interventions

BIOLOGICAL
DRUG

Results Available

NCT04291196 | COMPLETED | NA

66 participants

Virtual Reality to Reduce Pre-procedure Anxiety Prior ECT

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2020-11-27
Completion:: 2024-09-03

Conditions

ECT
Electroconvulsive Therapy
Virtual Reality
Anxiety
Education
Hemodynamics
Depression
Cognition
Mental Health

Interventions

OTHER

No Results Yet

NCT04269902 | RECRUITING | PHASE3

247 participants

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2021-03-02
Completion:: 2028-10-01

Conditions

Chronic Lymphocytic Leukemia
Small Lymphocytic Lymphoma

Interventions

PROCEDURE
BIOLOGICAL
OTHER
DRUG

No Results Yet

NCT04267861 | ACTIVE_NOT_RECRUITING

232 participants

M7824 Related Adverse Effects in Adults With Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-13
Start Date:: 2020-01-28
Completion:: 2027-11-01

Conditions

Neoplasms
Skin Neoplasms

No Results Yet

NCT04267848 | RECRUITING | PHASE3

1210 participants

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2020-06-16
Completion:: 2027-01-31

Conditions

Lung Non-Small Cell Carcinoma
Lung Non-Small Cell Squamous Carcinoma
Lung Non-Squamous Non-Small Cell Carcinoma
Stage II Lung Cancer AJCC v8
Stage IIIA Lung Cancer AJCC v8
Stage IIIB Lung Cancer AJCC v8

Interventions

PROCEDURE
DRUG
OTHER
BIOLOGICAL

No Results Yet

NCT04235777 | RECRUITING | PHASE1

100 participants

Bintrafusp Alfa (M7824) and PDS01ADC Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2020-07-13
Completion:: 2027-12-01

Conditions

Urothelial Cancer
Bladder Cancer
Genitourinary Cancer
Urogenital Neoplasms
Urogenital Cancer

Interventions

RADIATION
DRUG

No Results Yet

NCT04235764 | RECRUITING

25 participants

En-bloc Transurethral Resection of Bladder Tumor (En-bloc TURBT) Specimens Using a Redesigned Surgical Resectoscope Device

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-13
Start Date:: 2020-09-09
Completion:: 2026-09-30

Conditions

Bladder Cancer

Interventions

DEVICE
PROCEDURE

No Results Yet

NCT04220073 | COMPLETED | PHASE1

40 participants

Phase I Study of Comparing Single Dose JS005 (Recombinant Humanized Monoclonal Antibody Against IL-17A) With Placebo in Tolerability, Safety, Immunogenicity and Pharmacokinetic in Healthy Volunteers

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2020-05-17
Completion:: 2020-11-20

Conditions

Tolerability, Safety, Immunogenicity and Pharmacokinetic of JS005

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT04202393 | COMPLETED | NA

178 participants

Intervention for Comorbid Substance Use and Bipolar Disorders

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2020-10-21
Completion:: 2025-08-31

Conditions

Bipolar Disorder
Substance Use Disorders

Interventions

BEHAVIORAL

Results Available

NCT04190563 | COMPLETED | NA

83 participants

Pain, Inflammation and Opioid Craving

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2021-05-04
Completion:: 2025-07-31

Conditions

Opioid-use Disorder

Interventions

BEHAVIORAL

Results Available

NCT04181060 | RECRUITING | PHASE3

300 participants

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2020-12-28
Completion:: 2026-12-31

Conditions

Advanced Lung Non-Squamous Non-Small Cell Carcinoma
Metastatic Lung Non-Squamous Non-Small Cell Carcinoma
Recurrent Lung Non-Squamous Non-Small Cell Carcinoma
Stage IIIB Lung Cancer AJCC v8
Stage IV Lung Cancer AJCC v8

Interventions

BIOLOGICAL
PROCEDURE
DRUG

No Results Yet

NCT04170153 | ACTIVE_NOT_RECRUITING | PHASE1

161 participants

Tuvusertib (M1774) in Participants With Metastatic or Locally Advanced Unresectable Solid Tumors (DDRiver Solid Tumors 301)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2019-12-20
Completion:: 2026-11-30

Conditions

Metastatic or Locally Advanced Unresectable Solid Tumors

Interventions

DRUG

No Results Yet

NCT04166409 | RECRUITING | PHASE3

170 participants

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2020-01-31
Completion:: 2030-12-31

Conditions

Low Grade Astrocytoma
Low Grade Glioma
Metastatic Low Grade Astrocytoma
Metastatic Low Grade Glioma
WHO Grade 1 Glioma
WHO Grade 2 Glioma

Interventions

PROCEDURE
DRUG
OTHER

No Results Yet

NCT04113018 | ACTIVE_NOT_RECRUITING | PHASE2

39 participants

Study of Daratumumab Combined With Carfilzomib, Lenalidomide and Dexamethasone for Newly Diagnosed Multiple Myeloma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2020-01-10
Completion:: 2023-06-28

Conditions

Multiple Myeloma

Interventions

DRUG

Results Available

NCT04094701 | RECRUITING | NA

170 participants

Hip Arthroscopy Postoperative Opioid Demands

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2020-10-21
Completion:: 2027-11-30

Conditions

Opioid Use
Pain
Femoral Acetabular Impingement
Labral Tear, Glenoid

Interventions

OTHER

No Results Yet

NCT04086485 | RECRUITING | PHASE1/PHASE2

56 participants

Lu-177-DOTATATE (Lutathera) in Combination With Olaparib in Inoperable Gastroenteropancreatico Neuroendocrine Tumors (GEP-NET)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2022-10-03
Completion:: 2027-07-01

Conditions

Gastroenteropancreatico Tumors
Neuroendocrine Tumors
Neuroendocrine Neoplasms

Interventions

DRUG
DIAGNOSTIC_TEST

No Results Yet

NCT04083456 | COMPLETED | NA

35 participants

Dysvascular Amputation Self-Management of Health

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2019-11-01
Completion:: 2025-05-31

Conditions

Amputation
Diabetes Mellitus
Peripheral Artery Disease

Interventions

BEHAVIORAL
OTHER

Results Available

NCT04082429 | ACTIVE_NOT_RECRUITING | PHASE3

156 participants

Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia Without Inhibitors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2019-11-13
Completion:: 2022-07-12

Conditions

Haemophilia A Without Inhibitors
Haemophilia B Without Inhibitors

Interventions

DRUG

Results Available

NCT04036409 | COMPLETED | NA

4368 participants

Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Stroke Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2019-08-05
Completion:: 2026-07-08

Conditions

Ischemic Stroke
Blood Pressure
Cognitive Impairment
Vascular Diseases

Interventions

DRUG

No Results Yet

NCT04014348 | RECRUITING

250 participants

Geospatial Analysis of Neighborhood Environmental Stress in Relation to Biological Markers of Cardiovascular Health and Health Behaviors in Women

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-13
Start Date:: 2021-10-20
Completion:: 2026-12-10

Conditions

Cardiovascular (CV) Risk

No Results Yet

NCT04002947 | RECRUITING | PHASE2

132 participants

Acalabrutinib With DA-EPOCH-R or R-CHOP for People With Untreated Diffuse Large B-cell Lymphoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2019-08-05
Completion:: 2027-05-31

Conditions

Non-Hodgkin's Lymphoma
Diffuse Large B-Cell Lymphoma
DLBCL
NHL

Interventions

DRUG
BIOLOGICAL

No Results Yet

NCT03987555 | SUSPENDED

55 participants

Paclitaxel Therapeutic Drug Monitoring in Cancer Patients

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-13
Start Date:: 2019-11-11
Completion:: 2027-05-31

Conditions

Solid Tumor, Adult
Metastatic Nonsmall Cell Lung Cancer
Anatomic Stage IV Breast Cancer AJCC v8
Metastatic Cervical Carcinoma
Metastatic Ovarian Carcinoma
Malignant Uterine Neoplasm
Vulvar Cancer
Invasive Breast Cancer
Metastatic Breast Carcinoma
Prognostic Stage IV Breast Cancer AJCC v8
Recurrent Breast Carcinoma
Recurrent Cervical Carcinoma
Recurrent Lung Non-Small Cell Carcinoma
Recurrent Ovarian Carcinoma
Recurrent Vulvar Carcinoma
Stage IV Cervical Cancer AJCC v8
Stage IV Lung Cancer AJCC v8
Stage IV Vulvar Cancer AJCC v8
Stage IV Ovarian Cancer AJCC v8
Stage IVA Cervical Cancer AJCC v8
Stage IVA Lung Cancer AJCC v8
Stage IVA Ovarian Cancer AJCC v8
Stage IVA Vulvar Cancer AJCC v8
Stage IVB Cervical Cancer AJCC v8
Stage IVB Lung Cancer AJCC v8
Stage IVB Ovarian Cancer AJCC v8
Stage IVB Vulvar Cancer AJCC v8
Vulva Squamous Cell Carcinoma

Interventions

OTHER

No Results Yet

NCT03962127 | ACTIVE_NOT_RECRUITING

800 participants

MIDNOR-STROKE- a Long Term Follow-up Study of Patients With First Ever Ischemic Stroke in Central Norway

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-13
Start Date:: 2015-05-01
Completion:: 2026-08-31

Conditions

Stroke
Cardiovascular Diseases
Cardiovascular Risk Factor
Brain Ischemia
Cerebrovascular Disorders
Nervous System Diseases
Central Nervous System Lymphoma
Pathologic Processes
Vascular Diseases

Interventions

OTHER

No Results Yet

NCT03952598 | SUSPENDED | PHASE2

42 participants

Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR Spectroscopy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2019-10-16
Completion:: 2027-12-31

Conditions

Glioma
Gliomas
High Grade Glioma
Malignant Glioma
Low Grade Glioma

Interventions

DRUG
DEVICE

No Results Yet

NCT03924817 | ACTIVE_NOT_RECRUITING

500 participants

Registry Study on Prescription, Patient Pathways, Therapy Efficacy and Usage of Mandibular Advancement Devices in Obstructive Sleep Apnea - PATT-OSA Registry

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-13
Start Date:: 2024-02-01
Completion:: 2026-10-31

Conditions

Obstructive Sleep Apnea

No Results Yet

NCT03921944 | RECRUITING | NA

30 participants

Evaluation of Structural and Functional Integrity of the Rotator Cuff After Total Shoulder Arthroplasty

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2024-05-02
Completion:: 2028-09-30

Conditions

Osteoarthritis of Shoulder

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT03911128 | RECRUITING

500 participants

A Treatment Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-13
Start Date:: 2019-08-29
Completion:: 2033-06-30

Conditions

Leukemia, Acute Lymphoblastic

Interventions

OTHER

No Results Yet

NCT03895645 | ENROLLING_BY_INVITATION

1000 participants

Connors Protocol for the Management and Use of Stored Human Specimens (Stored Human Specimens)

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-13
Start Date:: 2026-08-18
Completion:: 2029-12-31

Conditions

Healthy Volunteer Samples

No Results Yet

NCT03878446 | ACTIVE_NOT_RECRUITING | PHASE2

62 participants

A Research Study in Children Born Small and Who Stayed Small. Treatment is Somapacitan Once a Week Compared to Norditropin® Once a Day

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2019-07-04
Completion:: 2021-05-05

Conditions

Short Stature Children Born Small for Gestational Age (SGA)

Interventions

DRUG

Results Available

NCT03871257 | ACTIVE_NOT_RECRUITING | PHASE3

165 participants

A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2020-01-15
Completion:: 2027-12-31

Conditions

Low Grade Glioma
Neurofibromatosis Type 1
Visual Pathway Glioma

Interventions

DRUG
PROCEDURE
OTHER

No Results Yet

NCT03858322 | ACTIVE_NOT_RECRUITING | PHASE1

41 participants

'ADVANCE' (A Pilot Trial)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2019-03-21
Completion:: 2020-11-10

Conditions

Breast Cancer

Interventions

DRUG

No Results Yet

NCT03841617 | RECRUITING | PHASE2

30 participants

The Use of 124-I-PET/CT Whole Body and Lesional Dosimetry in Differentiated Thyroid Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2019-07-29
Completion:: 2035-11-01

Conditions

Thyroid Cancer

Interventions

DRUG
RADIATION
OTHER

No Results Yet

NCT03831958 | RECRUITING

600 participants

Long-Term Follow-Up of Survivors of Pediatric Cushing Disease

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-13
Start Date:: 2019-03-04
Completion:: 2040-01-03

Conditions

Cushing Disease

No Results Yet

NCT03827343 | ACTIVE_NOT_RECRUITING

500 participants

Retrospective Study of Immunotherapy Related Toxicities and Factors Impacting Outcomes in Children and Adults With Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-13
Start Date:: 2019-01-23
Completion:: 2026-12-31

Conditions

Macrophage Activation Syndrome
Primary Hemophagocytic Lymphohistiocytosis

No Results Yet

NCT03814746 | ACTIVE_NOT_RECRUITING | PHASE3

254 participants

Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2019-07-26
Completion:: 2022-08-31

Conditions

Sickle Cell Disease (SCD)

Interventions

DRUG

Results Available

NCT03813407 | RECRUITING | PHASE3

140 participants

An Open-label Study to Assess Safety and Efficacy of SZC in Paediatric Patients With Hyperkalaemia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2019-04-02
Completion:: 2030-02-21

Conditions

Hyperkalaemia

Interventions

DRUG

No Results Yet

NCT03805919 | RECRUITING

500 participants

Men at High Genetic Risk for Prostate Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-13
Start Date:: 2019-03-27
Completion:: 2029-01-01

Conditions

Prostatic Neoplasms

No Results Yet

NCT03790098 | COMPLETED | NA

38 participants

Flow-Restorative Yoga to Decrease Pain and Inflammation

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2018-11-19
Completion:: 2019-04-27

Conditions

Pain
Inflammation

Interventions

BEHAVIORAL

No Results Yet

NCT03782207 | COMPLETED

2756 participants

A Study Investigating the Outcomes and Safety of Atezolizumab Under Real-World Conditions in Patients Treated in Routine Clinical Practice

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-13
Start Date:: 2019-02-07
Completion:: 2026-07-31

Conditions

Urothelial Carcinoma
Non-Small Cell Lung Cancer
Small Cell Lung Cancer
Hepatocellular Carcinoma

Interventions

DRUG

No Results Yet

NCT03737955 | RECRUITING | PHASE2

36 participants

Fractionated Gemtuzumab Ozogamicin in Treating Measurable Residual Disease in Patients With Acute Myeloid Leukemia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-13
Start Date:: 2018-11-30
Completion:: 2026-12-31

Conditions

Acute Myeloid Leukemia

Interventions

DRUG
OTHER
PROCEDURE

No Results Yet