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Clinical Trials

NCT03984448 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
363 participants

Testing the Addition of a New Anti-cancer Drug, Venetoclax, to Usual Chemotherapy for High Grade B-cell Lymphomas

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2019-10-22
Completion:
2028-04-01
Conditions
  • Diffuse Large B-Cell Lymphoma
  • Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
  • Double-Expressor Lymphoma
  • EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
  • High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements
  • High Grade B-Cell Lymphoma, Not Otherwise Specified
  • Neoplastic Cells With Double Expression of MYC and BCL2 Proteins Present
  • Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma
Interventions
  • PROCEDURE
  • DRUG
  • BIOLOGICAL
No Results Yet
NCT03907488 | ACTIVE_NOT_RECRUITING | PHASE3
994 participants

Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2019-08-29
Completion:
2024-03-31
Conditions
  • Ann Arbor Stage III Hodgkin Lymphoma
  • Ann Arbor Stage III Lymphocyte-Depleted Classic Hodgkin Lymphoma
  • Ann Arbor Stage III Mixed Cellularity Classic Hodgkin Lymphoma
  • Ann Arbor Stage III Nodular Sclerosis Classic Hodgkin Lymphoma
  • Ann Arbor Stage IV Hodgkin Lymphoma
  • Ann Arbor Stage IV Lymphocyte-Depleted Classic Hodgkin Lymphoma
  • Ann Arbor Stage IV Mixed Cellularity Classic Hodgkin Lymphoma
  • Ann Arbor Stage IV Nodular Sclerosis Classic Hodgkin Lymphoma
  • Classic Hodgkin Lymphoma
  • Lymphocyte-Rich Classic Hodgkin Lymphoma
Interventions
  • PROCEDURE
  • DRUG
  • BIOLOGICAL
  • OTHER
  • RADIATION
Results Available
NCT03811015 | ACTIVE_NOT_RECRUITING | PHASE3
636 participants

Testing Immunotherapy Versus Observation in Patients With HPV Throat Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2019-08-16
Completion:
2027-01-01
Conditions
  • Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
  • Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
Interventions
  • PROCEDURE
  • DRUG
  • OTHER
  • RADIATION
  • BIOLOGICAL
No Results Yet
NCT03811002 | ACTIVE_NOT_RECRUITING | PHASE3
544 participants

Testing the Addition of a New Immunotherapy Drug, Atezolizumab (MPDL3280A), to the Usual Chemoradiation (CRT) Therapy Treatment for Limited Stage Small Cell Lung Cancer (LS-SCLC)

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2019-07-26
Completion:
2024-04-21
Conditions
  • Limited Stage Lung Small Cell Carcinoma
  • Stage I Lung Cancer AJCC v8
  • Stage II Lung Cancer AJCC v8
  • Stage III Lung Cancer AJCC v8
Interventions
  • RADIATION
  • DRUG
  • PROCEDURE
  • OTHER
Results Available
NCT03793166 | ACTIVE_NOT_RECRUITING | PHASE3
1175 participants

Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2019-06-07
Completion:
2028-01-25
Conditions
  • Clear Cell Renal Cell Carcinoma
  • Metastatic Malignant Neoplasm in the Bone
  • Metastatic Malignant Neoplasm in the Lymph Nodes
  • Metastatic Malignant Neoplasm in the Soft Tissue
  • Metastatic Malignant Neoplasm in the Viscera
  • Rhabdoid Tumor of the Kidney
  • Sarcomatoid Renal Cell Carcinoma
  • Stage III Renal Cell Cancer AJCC v8
  • Stage IV Renal Cell Cancer AJCC v8
Interventions
  • PROCEDURE
  • DRUG
  • BIOLOGICAL
  • OTHER
No Results Yet
NCT03739814 | RECRUITING | PHASE2
84 participants

Inotuzumab Ozogamicin and Blinatumomab With or Without Ponatinib in Treating Patients With Newly Diagnosed, Recurrent, or Refractory CD22-Positive B-Lineage Acute Lymphoblastic Leukemia

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2019-05-08
Completion:
2027-02-01
Conditions
  • B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative
  • Recurrent B Acute Lymphoblastic Leukemia
  • Refractory B Acute Lymphoblastic Leukemia
Interventions
  • PROCEDURE
  • BIOLOGICAL
  • DRUG
No Results Yet
NCT03712605 | ACTIVE_NOT_RECRUITING | PHASE3
280 participants

Testing Pembrolizumab Versus Observation in Patients With Merkel Cell Carcinoma After Surgery, STAMP Trial

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2018-11-15
Completion:
2026-12-31
Conditions
  • Pathologic Stage I Cutaneous Merkel Cell Carcinoma AJCC v8
  • Pathologic Stage II Cutaneous Merkel Cell Carcinoma AJCC v8
  • Pathologic Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
Interventions
  • OTHER
  • PROCEDURE
  • BIOLOGICAL
  • RADIATION
No Results Yet
NCT03698019 | ACTIVE_NOT_RECRUITING | PHASE2
313 participants

A Study to Compare the Administration of Pembrolizumab After Surgery Versus Administration Both Before and After Surgery for High-Risk Melanoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2019-02-15
Completion:
2022-09-01
Conditions
  • Acral Lentiginous Melanoma
  • Clinical Stage III Cutaneous Melanoma AJCC v8
  • Clinical Stage IV Cutaneous Melanoma AJCC v8
  • Mucosal Melanoma
Interventions
  • PROCEDURE
  • BIOLOGICAL
Results Available
NCT03625037 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
666 participants

First-in-Human (FIH) Trial in Patients With Relapsed, Progressive or Refractory B-Cell Lymphoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2018-06-26
Completion:
2029-01-31
Conditions
  • DLBCL
  • High-grade B-cell Lymphoma (HGBCL)
  • Primary Mediastinal Large B-cell Lymphoma (PMBCL)
  • FL
  • MCL
  • Small Lymphocytic Lymphoma (SLL)
  • Marginal Zone Lymphoma (MZL)
  • Indolent B-cell Non-Hodgkin Lymphoma (iNHL)
  • Aggressive B-cell Non-Hodgkin Lymphoma (aNHL)
Interventions
  • BIOLOGICAL
No Results Yet
NCT03375320 | ACTIVE_NOT_RECRUITING | PHASE3
298 participants

Testing Cabozantinib in Patients With Advanced Pancreatic Neuroendocrine and Carcinoid Tumors

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2018-10-26
Completion:
2023-08-23
Conditions
  • Functioning Pancreatic Neuroendocrine Tumor
  • Intermediate Grade Lung Neuroendocrine Neoplasm
  • Locally Advanced Digestive System Neuroendocrine Neoplasm
  • Locally Advanced Digestive System Neuroendocrine Tumor G1
  • Locally Advanced Lung Neuroendocrine Neoplasm
  • Locally Advanced Pancreatic Neuroendocrine Tumor
  • Locally Advanced Unresectable Digestive System Neuroendocrine Neoplasm
  • Low Grade Lung Neuroendocrine Neoplasm
  • Lung Neuroendocrine Tumor
  • Lung Neuroendocrine Tumor G2
  • Metastatic Digestive System Neuroendocrine Neoplasm
  • Metastatic Digestive System Neuroendocrine Tumor G1
  • Metastatic Lung Neuroendocrine Neoplasm
  • Metastatic Lung Neuroendocrine Tumor
  • Metastatic Pancreatic Neuroendocrine Neoplasm
  • Metastatic Pancreatic Neuroendocrine Tumor
  • Metastatic Thymus Neuroendocrine Neoplasm
  • Neuroendocrine Neoplasm
  • Neuroendocrine Tumor
  • Neuroendocrine Tumor G2
  • Non-Functioning Pancreatic Neuroendocrine Tumor
  • Pancreatic Serotonin-Producing Neuroendocrine Tumor
  • Thymus Neuroendocrine Tumor
  • Unresectable Digestive System Neuroendocrine Neoplasm
  • Unresectable Digestive System Neuroendocrine Tumor G1
  • Unresectable Lung Neuroendocrine Neoplasm
  • Unresectable Pancreatic Neuroendocrine Neoplasm
  • Unresectable Thymus Neuroendocrine Neoplasm
Interventions
  • PROCEDURE
  • DRUG
  • OTHER
Results Available
NCT03244384 | ACTIVE_NOT_RECRUITING | PHASE3
739 participants

Testing MK-3475 (Pembrolizumab) After Surgery for Localized Muscle-Invasive Bladder Cancer and Locally Advanced Urothelial Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2017-11-03
Completion:
2026-10-31
Conditions
  • Localized Renal Pelvis and Ureter Urothelial Carcinoma
  • Locally Advanced Bladder Urothelial Carcinoma
  • Locally Advanced Renal Pelvis and Ureter Urothelial Carcinoma
  • Locally Advanced Ureter Urothelial Carcinoma
  • Locally Advanced Urothelial Carcinoma
  • Stage II Bladder Urothelial Carcinoma AJCC v6 and v7
  • Stage II Renal Pelvis and Ureter Cancer AJCC v7
  • Stage II Ureter Cancer AJCC v7
  • Stage III Bladder Urothelial Carcinoma AJCC v6 and v7
  • Stage III Renal Pelvis and Ureter Cancer AJCC v7
  • Stage III Ureter Cancer AJCC v7
Interventions
  • PROCEDURE
  • OTHER
  • BIOLOGICAL
No Results Yet
NCT03228537 | ACTIVE_NOT_RECRUITING | PHASE1
28 participants

Atezolizumab, Pemetrexed Disodium, Cisplatin, and Surgery With or Without Radiation Therapy in Treating Patients With Stage I-III Pleural Malignant Mesothelioma

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2018-07-16
Completion:
2022-10-01
Conditions
  • Biphasic Mesothelioma
  • Epithelioid Mesothelioma
  • Stage I Pleural Diffuse Malignant Mesothelioma AJCC v7
  • Stage IA Pleural Diffuse Malignant Mesothelioma AJCC v7
  • Stage IB Pleural Diffuse Malignant Mesothelioma AJCC v7
  • Stage II Pleural Diffuse Malignant Mesothelioma AJCC v7
  • Stage III Pleural Diffuse Malignant Mesothelioma AJCC v7
Interventions
  • DRUG
  • PROCEDURE
  • RADIATION
Results Available
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