Clinical Trials

NCT03698019 | ACTIVE_NOT_RECRUITING | PHASE2
313 participants

A Study to Compare the Administration of Pembrolizumab After Surgery Versus Administration Both Before and After Surgery for High-Risk Melanoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2019-02-15
Completion:
2022-09-01
Conditions
  • Acral Lentiginous Melanoma
  • Clinical Stage III Cutaneous Melanoma AJCC v8
  • Clinical Stage IV Cutaneous Melanoma AJCC v8
  • Mucosal Melanoma
Interventions
  • PROCEDURE
  • BIOLOGICAL
NCT03625037 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
666 participants

First-in-Human (FIH) Trial in Patients With Relapsed, Progressive or Refractory B-Cell Lymphoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2018-06-26
Completion:
2029-01-31
Conditions
  • DLBCL
  • High-grade B-cell Lymphoma (HGBCL)
  • Primary Mediastinal Large B-cell Lymphoma (PMBCL)
  • FL
  • MCL
  • Small Lymphocytic Lymphoma (SLL)
  • Marginal Zone Lymphoma (MZL)
  • Indolent B-cell Non-Hodgkin Lymphoma (iNHL)
  • Aggressive B-cell Non-Hodgkin Lymphoma (aNHL)
Interventions
  • BIOLOGICAL
No Results Yet
NCT03375320 | ACTIVE_NOT_RECRUITING | PHASE3
298 participants

Testing Cabozantinib in Patients With Advanced Pancreatic Neuroendocrine and Carcinoid Tumors

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2018-10-26
Completion:
2023-08-23
Conditions
  • Functioning Pancreatic Neuroendocrine Tumor
  • Intermediate Grade Lung Neuroendocrine Neoplasm
  • Locally Advanced Digestive System Neuroendocrine Neoplasm
  • Locally Advanced Digestive System Neuroendocrine Tumor G1
  • Locally Advanced Lung Neuroendocrine Neoplasm
  • Locally Advanced Pancreatic Neuroendocrine Tumor
  • Locally Advanced Unresectable Digestive System Neuroendocrine Neoplasm
  • Low Grade Lung Neuroendocrine Neoplasm
  • Lung Neuroendocrine Tumor
  • Lung Neuroendocrine Tumor G2
  • Metastatic Digestive System Neuroendocrine Neoplasm
  • Metastatic Digestive System Neuroendocrine Tumor G1
  • Metastatic Lung Neuroendocrine Neoplasm
  • Metastatic Lung Neuroendocrine Tumor
  • Metastatic Pancreatic Neuroendocrine Neoplasm
  • Metastatic Pancreatic Neuroendocrine Tumor
  • Metastatic Thymus Neuroendocrine Neoplasm
  • Neuroendocrine Neoplasm
  • Neuroendocrine Tumor
  • Neuroendocrine Tumor G2
  • Non-Functioning Pancreatic Neuroendocrine Tumor
  • Pancreatic Serotonin-Producing Neuroendocrine Tumor
  • Thymus Neuroendocrine Tumor
  • Unresectable Digestive System Neuroendocrine Neoplasm
  • Unresectable Digestive System Neuroendocrine Tumor G1
  • Unresectable Lung Neuroendocrine Neoplasm
  • Unresectable Pancreatic Neuroendocrine Neoplasm
  • Unresectable Thymus Neuroendocrine Neoplasm
Interventions
  • PROCEDURE
  • DRUG
  • OTHER
NCT03244384 | ACTIVE_NOT_RECRUITING | PHASE3
739 participants

Testing MK-3475 (Pembrolizumab) After Surgery for Localized Muscle-Invasive Bladder Cancer and Locally Advanced Urothelial Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2017-11-03
Completion:
2026-10-31
Conditions
  • Localized Renal Pelvis and Ureter Urothelial Carcinoma
  • Locally Advanced Bladder Urothelial Carcinoma
  • Locally Advanced Renal Pelvis and Ureter Urothelial Carcinoma
  • Locally Advanced Ureter Urothelial Carcinoma
  • Locally Advanced Urothelial Carcinoma
  • Stage II Bladder Urothelial Carcinoma AJCC v6 and v7
  • Stage II Renal Pelvis and Ureter Cancer AJCC v7
  • Stage II Ureter Cancer AJCC v7
  • Stage III Bladder Urothelial Carcinoma AJCC v6 and v7
  • Stage III Renal Pelvis and Ureter Cancer AJCC v7
  • Stage III Ureter Cancer AJCC v7
Interventions
  • PROCEDURE
  • OTHER
  • BIOLOGICAL
No Results Yet
NCT03228537 | ACTIVE_NOT_RECRUITING | PHASE1
28 participants

Atezolizumab, Pemetrexed Disodium, Cisplatin, and Surgery With or Without Radiation Therapy in Treating Patients With Stage I-III Pleural Malignant Mesothelioma

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2018-07-16
Completion:
2022-10-01
Conditions
  • Biphasic Mesothelioma
  • Epithelioid Mesothelioma
  • Stage I Pleural Diffuse Malignant Mesothelioma AJCC v7
  • Stage IA Pleural Diffuse Malignant Mesothelioma AJCC v7
  • Stage IB Pleural Diffuse Malignant Mesothelioma AJCC v7
  • Stage II Pleural Diffuse Malignant Mesothelioma AJCC v7
  • Stage III Pleural Diffuse Malignant Mesothelioma AJCC v7
Interventions
  • DRUG
  • PROCEDURE
  • RADIATION
NCT02839707 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
444 participants

Pegylated Liposomal Doxorubicin Hydrochloride With Atezolizumab and/or Bevacizumab in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2017-06-23
Completion:
2023-05-09
Conditions
  • Fallopian Tube High Grade Serous Adenocarcinoma
  • Ovarian High Grade Serous Adenocarcinoma
  • Ovarian Seromucinous Carcinoma
  • Primary Peritoneal High Grade Serous Adenocarcinoma
  • Recurrent Fallopian Tube Carcinoma
  • Recurrent Fallopian Tube Clear Cell Adenocarcinoma
  • Recurrent Fallopian Tube Endometrioid Adenocarcinoma
  • Recurrent Fallopian Tube Undifferentiated Carcinoma
  • Recurrent Ovarian Carcinoma
  • Recurrent Ovarian Clear Cell Adenocarcinoma
  • Recurrent Ovarian Endometrioid Adenocarcinoma
  • Recurrent Ovarian Undifferentiated Carcinoma
  • Recurrent Platinum-Resistant Fallopian Tube Carcinoma
  • Recurrent Platinum-Resistant Ovarian Carcinoma
  • Recurrent Platinum-Resistant Primary Peritoneal Carcinoma
  • Recurrent Primary Peritoneal Carcinoma
  • Recurrent Primary Peritoneal Clear Cell Adenocarcinoma
  • Recurrent Primary Peritoneal Endometrioid Adenocarcinoma
  • Recurrent Primary Peritoneal Undifferentiated Carcinoma
Interventions
  • DRUG
  • BIOLOGICAL
  • PROCEDURE
  • OTHER
NCT02698293 | WITHDRAWN | PHASE1
0 participants

PDT Plus Vitamin D3 for Anal Dysplasia

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2019-12-01
Completion:
2022-08-03
Conditions
  • Anal Dysplasia
  • Carcinoma in Situ
Interventions
  • DRUG
  • OTHER
No Results Yet
NCT02610465 | COMPLETED
148 participants

High Image Matrix CT Reconstruction

Study Type:
OBSERVATIONAL
Last Updated:
2026-08-04
Start Date:
2015-11-09
Completion:
2020-03-27
Conditions
  • Healthy Subjects
  • Pulmonary-Related Conditions
  • Cardiac-Related Conditions
No Results Yet
NCT02595944 | ACTIVE_NOT_RECRUITING | PHASE3
903 participants

Nivolumab After Surgery and Chemotherapy in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer (An ALCHEMIST Treatment Trial)

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2016-07-22
Completion:
2026-12-31
Conditions
  • Stage IB Lung Non-Small Cell Carcinoma AJCC v7
  • Stage II Lung Non-Small Cell Cancer AJCC v7
  • Stage IIIA Lung Non-Small Cell Cancer AJCC v7
Interventions
  • PROCEDURE
  • BIOLOGICAL
  • OTHER
No Results Yet
NCT02465060 | ACTIVE_NOT_RECRUITING | PHASE2
6452 participants

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2015-08-17
Completion:
2026-12-31
Conditions
  • Advanced Lymphoma
  • Advanced Malignant Solid Neoplasm
  • Bladder Carcinoma
  • Breast Carcinoma
  • Cervical Carcinoma
  • Colon Carcinoma
  • Colorectal Carcinoma
  • Endometrial Carcinoma
  • Esophageal Carcinoma
  • Exocrine Pancreas Carcinoma
  • Gastric Carcinoma
  • Glioma
  • Head and Neck Carcinoma
  • Hematopoietic and Lymphoid Cell Neoplasm
  • Kidney Carcinoma
  • Liver Carcinoma
  • Lung Carcinoma
  • Lymphoma
  • Malignant Uterine Corpus Neoplasm
  • Malignant Uterine Neoplasm
  • Melanoma
  • Multiple Myeloma
  • Ovarian Carcinoma
  • Prostate Carcinoma
  • Rectal Carcinoma
  • Recurrent Bladder Carcinoma
  • Recurrent Breast Carcinoma
  • Recurrent Cervical Carcinoma
  • Recurrent Colon Carcinoma
  • Recurrent Colorectal Carcinoma
  • Recurrent Esophageal Carcinoma
  • Recurrent Gastric Carcinoma
  • Recurrent Glioma
  • Recurrent Head and Neck Carcinoma
  • Recurrent Liver Carcinoma
  • Recurrent Lung Carcinoma
  • Recurrent Lymphoma
  • Recurrent Malignant Solid Neoplasm
  • Recurrent Malignant Uterine Corpus Neoplasm
  • Recurrent Melanoma
  • Recurrent Multiple Myeloma
  • Recurrent Ovarian Carcinoma
  • Recurrent Pancreatic Carcinoma
  • Recurrent Prostate Carcinoma
  • Recurrent Rectal Carcinoma
  • Recurrent Skin Carcinoma
  • Recurrent Thyroid Gland Carcinoma
  • Refractory Lymphoma
  • Refractory Malignant Solid Neoplasm
  • Refractory Multiple Myeloma
  • Skin Carcinoma
  • Thyroid Gland Carcinoma
Interventions
  • DRUG
  • PROCEDURE
  • OTHER
  • BIOLOGICAL
No Results Yet
NCT02257528 | ACTIVE_NOT_RECRUITING | PHASE2
26 participants

Nivolumab in Treating Patients With Persistent, Recurrent, or Metastatic Cervical Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2015-05-18
Completion:
2019-03-05
Conditions
  • Cervical Adenocarcinoma
  • Cervical Adenosquamous Carcinoma
  • Recurrent Cervical Carcinoma
  • Stage IV Cervical Cancer AJCC v6 and v7
  • Stage IVA Cervical Cancer AJCC v6 and v7
  • Stage IVB Cervical Cancer AJCC v6 and v7
Interventions
  • OTHER
  • BIOLOGICAL
NCT02224781 | ACTIVE_NOT_RECRUITING | PHASE3
267 participants

Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-04
Start Date:
2015-09-08
Completion:
2023-09-30
Conditions
  • Clinical Stage III Cutaneous Melanoma AJCC v8
  • Clinical Stage IV Cutaneous Melanoma AJCC v8
  • Metastatic Melanoma
  • Recurrent Melanoma
  • Unresectable Melanoma
Interventions
  • PROCEDURE
  • DRUG
  • BIOLOGICAL
  • OTHER
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