Clinical Trials

NCT03765918 | ACTIVE_NOT_RECRUITING | PHASE3

714 participants

Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-12-17
Completion:: 2024-07-25

Conditions

Head and Neck Neoplasms

Interventions

BIOLOGICAL
RADIATION
DRUG

Results Available

NCT03748641 | ACTIVE_NOT_RECRUITING | PHASE3

765 participants

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-01-25
Completion:: 2021-10-08

Conditions

Castration-Resistant Prostatic Cancer

Interventions

DRUG

Results Available

NCT03696784 | ACTIVE_NOT_RECRUITING | PHASE1

12 participants

Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-03-12
Completion:: 2025-08-31

Conditions

Lymphoma
Lymphoma, B-Cell
Immune System Diseases
Immunoproliferative Disorders
Lymphatic Diseases

Interventions

BIOLOGICAL
DRUG

Results Available

NCT03689595 | ENROLLING_BY_INVITATION

30000 participants

Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-10-31
Completion:: 2033-10-31

Conditions

Multiple Myeloma

Interventions

OTHER

No Results Yet

NCT03683251 | RECRUITING | PHASE3

1000 participants

Extension Study for the Port Delivery System With Ranibizumab (Portal)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-09-20
Completion:: 2029-12-31

Conditions

Neovascular Age-Related Macular Degeneration

Interventions

DRUG

No Results Yet

NCT03654079 | NOT_YET_RECRUITING | NA

50 participants

Patient Centered Simulation For Labor and Delivery

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2027-01-31
Completion:: 2027-11-30

Conditions

Pregnancy Related

Interventions

OTHER

No Results Yet

NCT03604978 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

38 participants

Nivolumab and Multi-fraction Stereotactic Radiosurgery With or Without Ipilimumab in Treating Patients With Recurrent Grade II-III Meningioma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-06-17
Completion:: 2027-03-19

Conditions

Grade 2 Meningioma
Grade 3 Meningioma
Recurrent Meningioma

Interventions

PROCEDURE
BIOLOGICAL
RADIATION

No Results Yet

NCT03528642 | ACTIVE_NOT_RECRUITING | PHASE1

40 participants

Telaglenastat With Radiation Therapy and Temozolomide in Treating Patients With IDH-Mutated Diffuse Astrocytoma or Anaplastic Astrocytoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-05-01
Completion:: 2026-09-11

Conditions

Astrocytoma, IDH-Mutant, Grade 2
Astrocytoma, IDH-Mutant, Grade 3

Interventions

OTHER
RADIATION
DRUG

No Results Yet

NCT03517969 | ACTIVE_NOT_RECRUITING | PHASE2

73 participants

M6620 and Carboplatin With or Without Docetaxel in Treating Patients With Metastatic Castration-Resistant Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-05-29
Completion:: 2021-08-10

Conditions

Castration-Resistant Prostate Carcinoma
Metastatic Prostate Carcinoma
Stage IV Prostate Cancer AJCC v8

Interventions

DRUG
OTHER

Results Available

NCT03446651 | COMPLETED | EARLY_PHASE1

50 participants

Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-07-12
Completion:: 2022-09-07

Conditions

Heart Failure

Interventions

DRUG
OTHER

Results Available

NCT03394365 | RECRUITING | PHASE3

115 participants

A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-12-29
Completion:: 2030-05-31

Conditions

Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD)
Solid Organ Transplant Complications
Lymphoproliferative Disorders
Allogeneic Hematopoietic Cell Transplant
Stem Cell Transplant Complications

Interventions

BIOLOGICAL

No Results Yet

NCT03386539 | COMPLETED | PHASE3

211 participants

Tacrolimus/Everolimus vs. Tacrolimus/MMF in Pediatric Heart Transplant Recipients Using the MATE Score

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-01-29
Completion:: 2023-04-17

Conditions

Pediatric Heart Transplantation
Immunosuppression
Chronic Kidney Diseases
Cardiac Allograft Vasculopathy
Heart Transplant Failure and Rejection
Post-transplant Lymphoproliferative Disorder
Heart Transplant Infection

Interventions

DRUG

Results Available

NCT03383458 | ACTIVE_NOT_RECRUITING | PHASE3

545 participants

A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-04-18
Completion:: 2026-05-27

Conditions

Hepatocellular Carcinoma
Liver Cancer

Interventions

BIOLOGICAL
OTHER

No Results Yet

NCT03334253 | COMPLETED | PHASE3

200 participants

Low-Dose Atropine for Treatment of Myopia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-06-01
Completion:: 2022-04-15

Conditions

Myopia

Interventions

DRUG
OTHER

Results Available

NCT03317392 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

132 participants

Testing the Safety of Different Doses of Olaparib Given Radium-223 for Men With Advanced Prostate Cancer With Bone Metastasis

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-02-04
Completion:: 2025-03-31

Conditions

Castration-Resistant Prostate Carcinoma
Metastatic Prostate Adenocarcinoma
Stage IVB Prostate Cancer AJCC v8

Interventions

PROCEDURE
OTHER
DRUG
RADIATION

Results Available

NCT03300817 | ACTIVE_NOT_RECRUITING | PHASE1

50 participants

MUC1 Vaccine in Preventing Lung Cancer in Current and Former Smokers at High Risk for Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-12-27
Completion:: 2021-09-23

Conditions

Lung Carcinoma

Interventions

OTHER
BIOLOGICAL

Results Available

NCT03287271 | TERMINATED | PHASE1/PHASE2

8 participants

ROCKIF Trial: Re-sensitization of Carboplatin-resistant Ovarian Cancer With Kinase Inhibition of FAK

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-02-06
Completion:: 2023-07-30

Conditions

Ovarian Cancer

Interventions

DRUG

Results Available

NCT03284385 | ACTIVE_NOT_RECRUITING | PHASE2

18 participants

Testing AZD1775 in Advanced Solid Tumors That Have a Mutation Called SETD2

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-01-29
Completion:: 2026-03-01

Conditions

Clear Cell Renal Cell Carcinoma
Locally Advanced Clear Cell Renal Cell Carcinoma
Locally Advanced Malignant Solid Neoplasm
Metastatic Malignant Solid Neoplasm
Metastatic Renal Cell Carcinoma
Stage III Renal Cell Cancer AJCC v8
Stage IV Renal Cell Cancer AJCC v8

Interventions

DRUG

No Results Yet

NCT03269422 | COMPLETED | PHASE1

35 participants

Radiotherapy to the Prostate and Dominant Intra-Prostatic Lesion (DIL)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-08-28
Completion:: 2026-07-29

Conditions

Prostate Cancer

Interventions

RADIATION

No Results Yet

NCT03246841 | ACTIVE_NOT_RECRUITING | NA

7274 participants

Investigation of Tumour Spectrum of Germline Mutations in Breast and Ovarian Cancer Genes.

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-09-21
Completion:: 2026-12-30

Conditions

Hereditary Breast and Ovarian Cancer
Mutation

Interventions

OTHER

No Results Yet

NCT03237780 | ACTIVE_NOT_RECRUITING | PHASE2

72 participants

Atezolizumab With or Without Eribulin Mesylate in Treating Patients With Recurrent Locally Advanced or Metastatic Urothelial Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-07-20
Completion:: 2027-06-30

Conditions

Locally Advanced Bladder Urothelial Carcinoma
Locally Advanced Renal Pelvis Urothelial Carcinoma
Locally Advanced Ureter Urothelial Carcinoma
Locally Advanced Urethral Urothelial Carcinoma
Metastatic Bladder Urothelial Carcinoma
Metastatic Renal Pelvis Urothelial Carcinoma
Metastatic Ureter Urothelial Carcinoma
Metastatic Urethral Urothelial Carcinoma
Recurrent Bladder Urothelial Carcinoma
Recurrent Renal Pelvis Urothelial Carcinoma
Recurrent Ureter Urothelial Carcinoma
Recurrent Urethral Urothelial Carcinoma
Stage III Bladder Cancer AJCC v8
Stage III Renal Pelvis Cancer AJCC v8
Stage III Ureter Cancer AJCC v8
Stage III Urethral Cancer AJCC v8
Stage IV Bladder Cancer AJCC v8
Stage IV Renal Pelvis Cancer AJCC v8
Stage IV Ureter Cancer AJCC v8
Stage IV Urethral Cancer AJCC v8
Unresectable Bladder Urothelial Carcinoma
Unresectable Renal Pelvis Urothelial Carcinoma
Unresectable Ureter Urothelial Carcinoma
Unresectable Urethral Urothelial Carcinoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT03188705 | COMPLETED | PHASE4

6 participants

CES1 Carriers in the PAPI Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2019-10-14
Completion:: 2020-01-17

Conditions

Heart Diseases
Coronary Disease
Coronary Artery Disease
Cardiovascular Diseases
Myocardial Ischemia
Artery Occlusion
Aspirin Sensitivity
Clopidogrel, Poor Metabolism of
Platelet Dysfunction
Platelet Thrombus

Interventions

DRUG

Results Available

NCT03145181 | ACTIVE_NOT_RECRUITING | PHASE1

302 participants

Dose Escalation Study of Teclistamab, a Humanized BCMA*CD3 Bispecific Antibody, in Participants With Relapsed or Refractory Multiple Myeloma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-05-16
Completion:: 2025-09-25

Conditions

Hematological Malignancies

Interventions

DRUG

No Results Yet

NCT03141684 | ACTIVE_NOT_RECRUITING | PHASE2

63 participants

Testing Atezolizumab Alone or Atezolizumab Plus Bevacizumab in People With Advanced Alveolar Soft Part Sarcoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-04-25
Completion:: 2026-10-31

Conditions

Metastatic Alveolar Soft Part Sarcoma
Unresectable Alveolar Soft Part Sarcoma

Interventions

DRUG
BIOLOGICAL
PROCEDURE

No Results Yet

NCT03115086 | ACTIVE_NOT_RECRUITING

55 participants

The REPLACE Registry for Cholbam® (Cholic Acid)

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-07-10
Completion:: 2038-07-31

Conditions

Bile Acid Synthesis Disorders

Interventions

DRUG

No Results Yet

NCT03108495 | TERMINATED | PHASE2

210 participants

Study of LN-145, Autologous Tumor Infiltrating Lymphocytes in the Treatment of Patients With Cervical Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-06-22
Completion:: 2025-08-22

Conditions

Cervical Carcinoma

Interventions

BIOLOGICAL

Results Available

NCT03099356 | RECRUITING | PHASE2

22 participants

Cyclophosphamide and Sirolimus for the Treatment of Metastatic, RAI-refractory, Differentiated Thyroid Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-04-27
Completion:: 2026-12-31

Conditions

Metastatic Thyroid Cancer

Interventions

DRUG

No Results Yet

NCT03091257 | ACTIVE_NOT_RECRUITING | PHASE1

30 participants

A Study of Dabrafenib and/or Trametinib in Patients With Relapsed and/or Refractory Multiple Myeloma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-06-21
Completion:: 2026-07-15

Conditions

Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT03055013 | ACTIVE_NOT_RECRUITING | PHASE3

819 participants

Nivolumab in Treating Patients With Localized Kidney Cancer Undergoing Nephrectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-04-28
Completion:: 2023-05-24

Conditions

Metastatic Renal Cell Carcinoma
Sarcomatoid Renal Cell Carcinoma
Stage II Renal Cell Cancer AJCC v7
Stage III Renal Cell Cancer AJCC v7
Unclassified Renal Cell Carcinoma

Interventions

PROCEDURE
BIOLOGICAL
OTHER

Results Available

NCT03053141 | RECRUITING

100 participants

RHythmia mAPping and Signal acquisitiOn for Data analYsis (RHAPSODY)

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-31
Start Date:: 2016-05-31
Completion:: 2027-12-31

Conditions

Cardiac Arrythmias

Interventions

DEVICE

No Results Yet

NCT03048422 | COMPLETED | PHASE3

643 participants

Evaluating the Efficacy and Safety of Dolutegravir-Containing Versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and Their Infants

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-01-19
Completion:: 2020-10-03

Conditions

HIV Infections

Interventions

DRUG

Results Available

NCT03047213 | ACTIVE_NOT_RECRUITING | PHASE2

17 participants

Sapanisertib in Treating Patients With Locally Advanced or Metastatic Bladder Cancer With TSC1 and/or TSC2 Mutations

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-08-24
Completion:: 2020-10-06

Conditions

Locally Advanced Bladder Urothelial Carcinoma
Metastatic Transitional Cell Carcinoma
Metastatic Urothelial Carcinoma
Recurrent Bladder Carcinoma
Stage III Bladder Urothelial Carcinoma AJCC v6 and v7
Stage IV Bladder Urothelial Carcinoma AJCC v7

Interventions

DRUG

Results Available

NCT03030378 | ACTIVE_NOT_RECRUITING | PHASE1

36 participants

Pembrolizumab and Recombinant Interleukin-12 in Treating Patients With Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-05-30
Completion:: 2026-12-01

Conditions

Metastatic Malignant Solid Neoplasm
Unresectable Malignant Solid Neoplasm

Interventions

PROCEDURE
BIOLOGICAL

No Results Yet

NCT03011814 | RECRUITING | PHASE1/PHASE2

78 participants

Durvalumab With or Without Lenalidomide in Treating Patients With Relapsed or Refractory Cutaneous or Peripheral T Cell Lymphoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-03-08
Completion:: 2030-04-14

Conditions

Folliculotropic Mycosis Fungoides
Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma
Recurrent Mycosis Fungoides
Refractory Cutaneous T-Cell Non-Hodgkin Lymphoma
Refractory Mycosis Fungoides
Refractory Peripheral T-Cell Lymphoma, Not Otherwise Specified
Sezary Syndrome
Recurrent Mature T- and NK-Cell Non-Hodgkin Lymphoma

Interventions

BIOLOGICAL
OTHER
DRUG

No Results Yet

NCT03000101 | COMPLETED | NA

18 participants

Study of the Role of Pomegranate Juice Ellagitannins in the Modulation of Inflammation in Inflammatory Bowel Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-01-19
Completion:: 2023-07-19

Conditions

Crohn's Disease
Ulcerative Colitis

Interventions

OTHER

No Results Yet

NCT02997228 | ACTIVE_NOT_RECRUITING | PHASE3

120 participants

Testing the Addition of Atezolizumab to Combination Chemotherapy or Atezolizumab Alone for Metastatic Colon or Rectal Cancer, the COMMIT Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-01-19
Completion:: 2027-06-01

Conditions

Metastatic Colorectal Adenocarcinoma
Stage IV Colorectal Cancer AJCC v7

Interventions

DRUG
BIOLOGICAL
PROCEDURE
OTHER

No Results Yet

NCT02954874 | ACTIVE_NOT_RECRUITING | PHASE3

1155 participants

Testing MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-01-18
Completion:: 2026-08-31

Conditions

Breast Carcinoma In Situ
Invasive Breast Carcinoma
Stage I Breast Cancer AJCC v7
Stage II Breast Cancer AJCC v6 and v7
Stage III Breast Cancer AJCC v7
Triple-Negative Breast Carcinoma

Interventions

PROCEDURE
OTHER
BIOLOGICAL
RADIATION

No Results Yet

NCT02908906 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

234 participants

A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of JNJ-63723283, an Anti-PD-1 Monoclonal Antibody, in Participants With Advanced Cancers

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2016-11-21
Completion:: 2023-11-17

Conditions

Neoplasms

Interventions

DRUG

No Results Yet

NCT02905591 | ACTIVE_NOT_RECRUITING | PHASE2

43 participants

A Phase 2 Study Adding Ascorbate to Chemotherapy and Radiation Therapy for NSCLC

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2018-11-16
Completion:: 2025-07-15

Conditions

Carcinoma, Non-Small-Cell Lung
Non-Small Cell Lung Cancer
Nonsmall Cell Lung Cancer
Non-Small-Cell Lung Carcinoma
NSCLC

Interventions

DRUG

Results Available

NCT02893917 | ACTIVE_NOT_RECRUITING | PHASE2

90 participants

Testing Two Oral Drugs Combination (Cediranib and Olaparib) Compared to a Single Drug (Olaparib) for Men With Advanced Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-31
Start Date:: 2017-08-11
Completion:: 2023-03-14

Conditions

Advanced Prostate Adenocarcinoma With Neuroendocrine Differentiation
Castration-Resistant Prostate Carcinoma
Metastatic Prostate Adenocarcinoma With Neuroendocrine Differentiation
Metastatic Prostate Carcinoma
Prostate Adenocarcinoma With Neuroendocrine Differentiation
Stage IV Prostate Adenocarcinoma AJCC v7

Interventions

DRUG

Results Available