Clinical Trials

NCT04784715 | ACTIVE_NOT_RECRUITING | PHASE3

1157 participants

Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2021-04-26

Completion:

2026-11-11

Conditions

• Breast Cancer; HER2-positive; Metastatic

Interventions

• DRUG

No Results Yet

NCT04761055 | COMPLETED | NA

300 participants

Study of iBreast, a Handheld Device to Detect Breast Abnormalities During Screening Visits for Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2021-01-29

Completion:

2025-08-19

Conditions

• Breast Screening

Interventions

• OTHER
• DEVICE
• DIAGNOSTIC_TEST

Results Available

NCT04718168 | RECRUITING | NA

245 participants

GORE® ENFORM Biomaterial Product Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2021-05-17

Completion:

2026-09-30

Conditions

• Hernia, Ventral
• Hernia, Hiatal
• Hernia, Diaphragmatic
• Incisional Hernia

Interventions

• DEVICE

No Results Yet

NCT04684589 | COMPLETED | PHASE2

99 participants

Effect of PDE5 Inhibition on Adipose Metabolism in Humans

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2021-03-16

Completion:

2025-06-20

Conditions

• Obesity

Interventions

• DRUG

Results Available

NCT04678856 | COMPLETED | PHASE2

71 participants

Dupilumab in CRSsNP

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2020-12-02

Completion:

2023-11-14

Conditions

• Chronic Rhinosinusitis Without Nasal Polyps
• Sinusitis
• Chronic Sinusitis
• Sinus Disorder
• Respiratory Disorder

Interventions

• DRUG

Results Available

NCT04673357 | COMPLETED | PHASE3

101 participants

A Study of Ustekinumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2021-04-06

Completion:

2024-11-28

Conditions

• Crohn Disease

Interventions

• DRUG

Results Available

NCT04657068 | RECRUITING | PHASE1/PHASE2

542 participants

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2021-01-27

Completion:

2028-01-31

Conditions

• Advanced Cancer
• Metastatic Cancer
• Ovarian Cancer
• Primary Peritoneal Cancer
• Fallopian Tube Cancer
• Endometrial Cancer
• Metastatic Colorectal Cancer
• Pancreatic Ductal Adenocarcinoma
• Acinar Cell Carcinoma

Interventions

• DRUG

No Results Yet

NCT04634643 | RECRUITING

260 participants

Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-30

Start Date:

2021-06-28

Completion:

2027-01-30

Conditions

• NAFLD

Interventions

• OTHER

No Results Yet

NCT04627818 | RECRUITING

1500 participants

Diagnostic, Therapeutic and Reproductive Aspects of Patients With Mullerian Anomalies

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-30

Start Date:

2021-01-01

Completion:

2050-12-31

Conditions

• Mullerian Anomaly of Uterus, Nec
• Mullerian Anomaly of Vagina
• Mullerian Anomaly of Cervix

No Results Yet

NCT04626518 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

370 participants

Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participants With Second Line Plus (2L+) Renal Cell Carcinoma (MK-3475-03B/KEYMAKER-U03)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2020-12-17

Completion:

2026-08-21

Conditions

• Carcinoma, Renal Cell

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT04626479 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

400 participants

Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2020-12-16

Completion:

2026-08-21

Conditions

• Carcinoma, Renal Cell

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT04620239 | ACTIVE_NOT_RECRUITING | PHASE3

89 participants

ENdoluminal LIGHT ActivatED Treatment of Upper Tract Urothelial Cancer (ENLIGHTED) Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2021-03-22

Completion:

2026-07-01

Conditions

• Transitional Cell Cancer of Renal Pelvis and Ureter

Interventions

• DRUG

No Results Yet

NCT04617834 | ACTIVE_NOT_RECRUITING

215 participants

Enhancing Rural Health Via Cardiovascular Telehealth for Rural Patients Implementation (E-VICTORS)

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-30

Start Date:

2021-02-01

Completion:

2025-08-31

Conditions

• Cardiovascular Diseases
• Acute Coronary Syndrome

Interventions

• OTHER

No Results Yet

NCT04606771 | ACTIVE_NOT_RECRUITING | PHASE2

30 participants

A Study Comparing Savolitinib Plus Osimertinib vs Savolitinib Plus Placebo in Patients With EGFRm+ and MET Amplified Advanced NSCLC

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2020-09-28

Completion:

2022-12-21

Conditions

• Non-Small Cell Lung Cancer

Interventions

• DRUG

Results Available

NCT04585893 | COMPLETED | PHASE2

15 participants

Safety and Efficacy of Rituximab for Treatment of Multicentric Castleman Disease in Malawi

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2021-06-22

Completion:

2024-08-30

Conditions

• Multicentric Castleman Disease

Interventions

• DRUG

Results Available

NCT04557462 | ACTIVE_NOT_RECRUITING | PHASE3

448 participants

A Rollover Extension Program (REP) to Evaluate the Long-term Safety and Tolerability of Open Label Iptacopan/LNP023 in Participants With Primary IgA Nephropathy

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2021-09-20

Completion:

2030-12-04

Conditions

• Primary IgA Nephropathy

Interventions

• DRUG

No Results Yet

NCT04555577 | ACTIVE_NOT_RECRUITING | PHASE1

29 participants

Phase I Trial of DNA-PK Inhibitor (PEPOSERTIB ) in Combination With Radiation and Adjuvant Temozolomide in Newly Diagnosed MGMT Unmethylated and Recurrent Glioblastoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2020-09-20

Completion:

2027-12-31

Conditions

• Glioblastoma
• Gliosarcoma

Interventions

• DRUG
• RADIATION
• PROCEDURE

No Results Yet

NCT04544436 | ACTIVE_NOT_RECRUITING | PHASE3

864 participants

A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2020-11-26

Completion:

2024-12-19

Conditions

• Multiple Sclerosis

Interventions

• DRUG

Results Available

NCT04543097 | TERMINATED | NA

130 participants

Work And Vocational advicE Study - Effectiveness of Adding a Brief Vocational Support Intervention to Usual Primary Care

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2020-12-23

Completion:

2023-04-20

Conditions

• Musculoskeletal Pain
• Mental Health Issue
• Mental Health Disorder
• Other Physical Health Condition
• Absence

Interventions

• BEHAVIORAL

Results Available

NCT04521673 | RECRUITING

100 participants

Pathogen Detection in Infectious Uveitis

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-30

Start Date:

2025-02-26

Completion:

2025-12-31

Conditions

• Infectious Panuveitis
• Infectious Iridocyclitis

No Results Yet

NCT04511845 | COMPLETED | PHASE1

85 participants

A Dose-Escalation Study of SPYK04 in Patients With Locally Advanced or Metastatic Solid Tumors (With Expansion).

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2020-09-10

Completion:

2026-06-18

Conditions

• Locally Advanced or Metastatic Solid Tumors

Interventions

• DRUG

No Results Yet

NCT04502316 | TERMINATED

435 participants

Real-World Experience - Barostim™ Advancing the Level of Clinical Evidence (REBALANCE Registry)

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-30

Start Date:

2020-06-26

Completion:

2026-05-14

Conditions

• Heart Failure

Interventions

• DEVICE

No Results Yet

NCT04458584 | RECRUITING

165 participants

Restoration of Thumb Strength and Function in Basal Joint Arthritis: A Comparative Effectiveness Trial (RESTART)

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-30

Start Date:

2020-06-29

Completion:

2026-12-31

Conditions

• Osteoarthritis Thumb

Interventions

• PROCEDURE

No Results Yet

NCT04439227 | ACTIVE_NOT_RECRUITING | PHASE2

33 participants

Testing AZD1775 as a Potential Targeted Treatment in Cancers With BRCA Genetic Changes (MATCH-Subprotocol Z1I)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2017-03-24

Completion:

2020-05-29

Conditions

• Advanced Lymphoma
• Advanced Malignant Solid Neoplasm
• Hematopoietic and Lymphoid Cell Neoplasm
• Refractory Lymphoma
• Refractory Malignant Solid Neoplasm
• Refractory Multiple Myeloma

Interventions

• DRUG

No Results Yet

NCT04419584 | RECRUITING | PHASE2/PHASE3

64 participants

Evaluate the Efficacy of Using Modified Qing-Ying Decoction in Atopic Dermatitis Children

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2020-09-10

Completion:

2027-06-30

Conditions

• Atopic Dermatitis

Interventions

• DRUG

No Results Yet

NCT04363684 | RECRUITING

2100 participants

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-30

Start Date:

2020-03-01

Completion:

2030-08-31

Conditions

• Frontotemporal Lobar Degeneration (FTLD)
• Progressive Supranuclear Palsy (PSP)
• Corticobasal Degeneration (CBD)
• Behavioral Variant Frontotemporal Dementia (bvFTD)
• Semantic Variant Primary Progressive Aphasia (svPPA)
• Nonfluent Variant Primary Progressive Aphasia (nfvPPA)
• FTD With Amyotrophic Lateral Sclerosis (FTD/ALS)
• Amyotrophic Lateral Sclerosis
• Oligosymptomatic PSP (oPSP)
• C9orf72
• GRN Related Frontotemporal Dementia
• MAPT Gene Mutation
• TBK1 Gene Mutation
• Oligosymptomatic Progressive Supranuclear Palsy

No Results Yet

NCT04360395 | ACTIVE_NOT_RECRUITING | NA

120 participants

Igniting Mobility in Adolescents and Young Adults With Cerebral Palsy

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2020-08-03

Completion:

2027-05-31

Conditions

• Cerebral Palsy

Interventions

• BEHAVIORAL

No Results Yet

NCT04340882 | ACTIVE_NOT_RECRUITING | PHASE2

30 participants

Phase 2 DoceRamPem for Patients With Metastatic or Recurrent NSCLC Who Progressed on Platinum-Doublet and PD-1/PD-L1 Blockade

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2020-06-05

Completion:

2026-09-02

Conditions

• Metastatic Non-Small Lung Cell Cancer
• Recurrent Non-Small Lung Cell Cancer
• Stage IV Lung Cancer AJCC v8
• Stage IVA Lung Cancer AJCC v8
• Stage IVB Lung Cancer AJCC v8

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT04337177 | ACTIVE_NOT_RECRUITING | PHASE1

20 participants

Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2021-10-25

Completion:

2026-12-31

Conditions

• Solid Tumors
• Neuroblastoma
• Rhabdomyosarcoma
• Ewing Sarcoma
• Hepatoblastoma
• Medulloblastoma

Interventions

• DRUG

No Results Yet

NCT04335799 | ACTIVE_NOT_RECRUITING | NA

341 participants

Reducing Weight and Elevated Stress Levels Using Educational and Behavioral Tools

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2021-10-12

Completion:

2025-12-19

Conditions

• Obesity

Interventions

• BEHAVIORAL

No Results Yet

NCT04329962 | COMPLETED | NA

12 participants

Metabolism and Absorption of Anthocyanins From Extract and Whole Blueberry Powder Confections in Healthy Adults

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2018-05-08

Completion:

2018-05-14

Conditions

• Healthy Diet
• Nutrition Aspect of Cancer

Interventions

• OTHER

No Results Yet

NCT04290546 | COMPLETED | PHASE1

11 participants

CIML NK Cell in Head & Neck Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2020-07-20

Completion:

2024-09-01

Conditions

• Squamous Cell Carcinoma of the Head and Neck
• Recurrent Head and Neck Squamous Cell Carcinoma

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT04268524 | COMPLETED | PHASE3

645 participants

Randomised Clinical Trial in Treatment Modalities for Cutaneous Leishmaniasis Caused by Leishmania Tropica, in Pakistan

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2022-10-07

Completion:

2026-06-19

Conditions

• Old World Cutaneous Leishmaniasis

Interventions

• COMBINATION_PRODUCT

No Results Yet

NCT04263584 | COMPLETED | PHASE2

62 participants

Copanlisib in Combination With Rituximab and CHOP Chemotherapy in Patients With Previously Untreated DLBCL

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2020-06-19

Completion:

2025-05-03

Conditions

• Diffuse Large B Cell Lymphoma

Interventions

• DRUG

No Results Yet

NCT04241328 | RECRUITING

5000 participants

Medtronic SYMBIOSIS Post-Market Registry for Patients Undergoing Cardiac Surgery

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-30

Start Date:

2020-01-09

Completion:

2026-12-31

Conditions

• Cardiovascular Diseases

No Results Yet

NCT04195399 | ACTIVE_NOT_RECRUITING | PHASE2

31 participants

A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2020-10-07

Completion:

2026-03-31

Conditions

• Desmoid Fibromatosis
• Recurrent Desmoid Fibromatosis
• Unresectable Desmoid Fibromatosis

Interventions

• PROCEDURE
• DRUG
• OTHER

No Results Yet

NCT04194775 | ACTIVE_NOT_RECRUITING | PHASE3

534 participants

A Study of Nofazinlimab (CS1003) in Subjects With Advanced Hepatocellular Carcinoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2019-12-13

Completion:

2025-06-18

Conditions

• Hepatocellular Carcinoma

Interventions

• DRUG

Results Available

NCT04165798 | RECRUITING

1065 participants

KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-30

Start Date:

2019-12-19

Completion:

2032-02-13

Conditions

• Carcinoma, Non-Small-Cell Lung

Interventions

• DIAGNOSTIC_TEST
• PROCEDURE

No Results Yet

NCT04165070 | RECRUITING | PHASE1/PHASE2

450 participants

KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2019-12-19

Completion:

2032-02-13

Conditions

• Carcinoma, Non-Small-Cell Lung

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT04131907 | ACTIVE_NOT_RECRUITING | NA

162 participants

Optilume™ BPH Catheter System in Men With Symptomatic BPH

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-30

Start Date:

2020-02-05

Completion:

2022-08-23

Conditions

• Benign Prostatic Hyperplasia

Interventions

• DEVICE

Results Available