Clinical Trials

NCT04975308 | ACTIVE_NOT_RECRUITING | PHASE3

874 participants

A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-10-04

Completion:

2024-06-24

Conditions

• Breast Neoplasms
• Neoplasm Metastasis

Interventions

• DRUG

Results Available

NCT04970056 | RECRUITING

20000 participants

Pancreatic Cancer Early Detection Consortium

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-22

Start Date:

2020-09-18

Completion:

2030-12-31

Conditions

• Pancreas Cancer
• Pancreas Cyst
• Pancreatic Ductal Adenocarcinoma
• Genetic Predisposition

No Results Yet

NCT04967170 | COMPLETED | PHASE1/PHASE2

30 participants

A Study to Evaluate Platelet Rich Plasma to Treat Vulvar Lichen Sclerosus

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-01-19

Completion:

2025-12-12

Conditions

• Vulvar Lichen Sclerosus

Interventions

• BIOLOGICAL
• OTHER

No Results Yet

NCT04957095 | RECRUITING | NA

120 participants

Motor Network Physiology

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-02-18

Completion:

2027-12-01

Conditions

• Parkinson Disease
• Essential Tremor

Interventions

• DRUG
• OTHER

No Results Yet

NCT04950127 | COMPLETED | PHASE3

238 participants

Global Linerixibat Itch Study of Efficacy and Safety in Primary Biliary Cholangitis (PBC) (GLISTEN)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-08-27

Completion:

2024-10-28

Conditions

• Pruritus

Interventions

• DRUG

Results Available

NCT04949529 | COMPLETED

355 participants

Falls: A Marker of Preclinical AD

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-22

Start Date:

2019-03-07

Completion:

2025-04-30

Conditions

• Fall
• Alzheimer Disease

Results Available

NCT04925375 | RECRUITING | PHASE2

38 participants

Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-07-14

Completion:

2028-07-31

Conditions

• Interstitial Lung Disease
• Common Variable Immunodeficiency

Interventions

• DRUG
• OTHER

No Results Yet

NCT04920136 | RECRUITING | NA

20 participants

Gain of Keratinized Mucosa Around Teeth and Dental Implants Using a Combination of Strip Gingival Graft and Acellular Dermal Matrix

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-09-17

Completion:

2026-12-30

Conditions

• Gingival Recession
• Lack of Keratinized Attached Peri-implant Mucosa
• Thin Gingiva

Interventions

• PROCEDURE

No Results Yet

NCT04917796 | ACTIVE_NOT_RECRUITING | NA

255 participants

The Effect of Electroacupuncture on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-05-21

Completion:

2026-09-24

Conditions

• Chemotherapy-induced Peripheral Neuropathy
• Nerve Pain
• Neuropathy
• Neuropathy, Painful
• Pain
• CIPN - Chemotherapy-Induced Peripheral Neuropathy

Interventions

• OTHER

No Results Yet

NCT04899037 | RECRUITING

50 participants

Pilot Study to Evaluate the Long-term Chronic Care of Patients Who Could or do Utilize an Osseointegrated Device (OID)

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-22

Start Date:

2021-01-29

Completion:

2027-12-31

Conditions

• Hearing Loss, Conductive
• Hearing Loss, Mixed
• Deafness, Unilateral

Interventions

• OTHER

No Results Yet

NCT04895358 | ACTIVE_NOT_RECRUITING | PHASE3

342 participants

Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-06-18

Completion:

2026-04-24

Conditions

• Breast Neoplasms

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT04892810 | COMPLETED

20 participants

Immunomonitoring of Interventional Radiology Procedures in the Management of Hepatocellular Carcinoma

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-22

Start Date:

2022-02-03

Completion:

2026-06-10

Conditions

• Hepatocellular Carcinoma

Interventions

• PROCEDURE

No Results Yet

NCT04879329 | RECRUITING | PHASE2

372 participants

A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-05-03

Completion:

2026-12-11

Conditions

• Urothelial Carcinoma

Interventions

• DRUG

No Results Yet

NCT04877613 | ACTIVE_NOT_RECRUITING | PHASE1

9 participants

GFRα4 CAR T Cells in MTC Patients

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-08-19

Completion:

2039-06-01

Conditions

• Metastatic Medullary Thyroid Cancer
• Recurrent Thyroid Gland Medullary Carcinoma

Interventions

• DRUG

No Results Yet

NCT04873401 | COMPLETED | NA

498 participants

Leveraging Social Networks to Increase COVID-19 Testing Uptake

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-04-20

Completion:

2022-03-18

Conditions

• Covid-19
• Substance Use
• Opioid Use

Interventions

• BEHAVIORAL

Results Available

NCT04868903 | COMPLETED | NA

1475 participants

Low vs. Moderate to High Dose Vitamin D for Prevention of COVID-19

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2020-11-30

Completion:

2024-12-01

Conditions

• SARS-CoV-2 Infection

Interventions

• DIETARY_SUPPLEMENT

Results Available

NCT04864418 | COMPLETED | PHASE1

22 participants

AST-021p Study in Advanced Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-06-09

Completion:

2023-11-02

Conditions

• Advanced Cancer

Interventions

• DRUG

No Results Yet

NCT04799470 | RECRUITING | NA

10 participants

Novel DBS Stimulation Patterns for Treatment of Parkinson's Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-05-10

Completion:

2028-04-30

Conditions

• Parkinson's Disease

Interventions

• DEVICE

No Results Yet

NCT04798833 | COMPLETED | NA

19344 participants

Newborn Care Kit to Save Lives in GB, Pakistan

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-03-01

Completion:

2024-08-31

Conditions

• Neonatal Mortality
• Omphalitis
• Post-Partum Hemorrhage

Interventions

• DEVICE

No Results Yet

NCT04781673 | ACTIVE_NOT_RECRUITING | PHASE4

74 participants

Ketamine vs Lidocaine in Traumatic Rib Fractures

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-04-01

Completion:

2024-10-10

Conditions

• Rib Fractures
• Rib Fracture Multiple
• Rib Trauma

Interventions

• DRUG

No Results Yet

NCT04776447 | COMPLETED | PHASE2

38 participants

Atezolizumab Plus Induction Chemotherapy Plus CT-radiotherapy. (APOLO)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-06-16

Completion:

2025-01-15

Conditions

• Lung Diseases
• Carcinoma, Non-Small-Cell Lung
• Stage IIIA Non-small Cell Lung Cancer
• Stage IIIB Non-small Cell Lung Cancer
• Respiratory Tract Neoplasms
• Carcinoma Bronchiogenic Stage III
• Thoracic Neoplasms

Interventions

• DRUG

Results Available

NCT04714892 | RECRUITING

350 participants

Mechanisms Underlying Individual Variations of Taste and Smell in Obesity

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-22

Start Date:

2022-05-11

Completion:

2026-12-30

Conditions

• Obesity

No Results Yet

NCT04678154 | RECRUITING | PHASE3

600 participants

Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT 2

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-05-07

Completion:

2028-09-30

Conditions

• Post Operative Surgical Site Infection

Interventions

• DRUG

No Results Yet

NCT04607005 | COMPLETED | PHASE3

169 participants

Efficacy and Safety of Mepolizumab in Adults With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)/ Eosinophilic Chronic Rhinosinusitis (ECRS)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-02-08

Completion:

2023-04-12

Conditions

• Nasal Polyps

Interventions

• DRUG

Results Available

NCT04603001 | ACTIVE_NOT_RECRUITING | PHASE1

260 participants

Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2020-11-19

Completion:

2023-07-03

Conditions

• Acute Myeloid Leukemia (AML)
• Myelodysplastic Syndrome (MDS)
• Chronic Myelomonocytic Leukemia (CMML)
• Myeloproliferative Neoplasms (MPNs)

Interventions

• DRUG

No Results Yet

NCT04597008 | COMPLETED | PHASE3

1660 participants

Topical Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: TOBRA

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-06-18

Completion:

2025-07-30

Conditions

• Post Operative Surgical Site Infection

Interventions

• DRUG

Results Available

NCT04535544 | COMPLETED | PHASE2

52 participants

A Study of JNJ-73763989 + Nucleos(t)Ide Analog in Participants Co-Infected With Hepatitis B and Hepatitis D Virus

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2020-09-17

Completion:

2023-10-19

Conditions

• Hepatitis D, Chronic

Interventions

• DRUG

Results Available

NCT04526093 | RECRUITING

1000 participants

Real-World Evidence in Patient-Reported Outcomes for Medical Cannabis (MC-RWE)

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-22

Start Date:

2020-07-15

Completion:

2028-03-31

Conditions

• Pain
• Sleep
• Anxiety
• Depression
• Epilepsy

Interventions

• OTHER

No Results Yet

NCT04521686 | ACTIVE_NOT_RECRUITING | PHASE1

200 participants

Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 or IDH2 Mutations

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2020-10-01

Completion:

2023-07-17

Conditions

• Cholangiocarcinoma
• Chondrosarcoma
• Glioma
• Any Solid Tumor

Interventions

• DRUG

No Results Yet

NCT04491292 | RECRUITING

20000 participants

Assessment of the Psychosocial Impact of the COVID-19 Pandemic on the MD Anderson Cancer Center Workforce

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-22

Start Date:

2020-05-18

Completion:

2028-04-30

Conditions

• COVID-19 Infection

Interventions

• OTHER

No Results Yet

NCT04461509 | TERMINATED | PHASE2

62 participants

High Resolution, 18F-PSMA PET-MRI Before Prostate Cancer HIFU or Radical Prostatectomy

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-04-06

Completion:

2024-09-03

Conditions

• Prostatic Neoplasms
• Genital Neoplasms, Male
• Urogenital Neoplasms
• Neoplasms by Site
• Neoplasms
• Genital Diseases, Male
• Prostatic Disease

Interventions

• DRUG

Results Available

NCT04427384 | RECRUITING

600 participants

Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-22

Start Date:

2020-09-11

Completion:

2028-10-31

Conditions

• Brain Tumor, Recurrent
• Brain Tumor
• Brain Tumor, Primary
• Brain Tumor - Metastatic
• Brain Tumor, Adult: Glioblastoma
• Brain Tumor, Adult Meningioma

Interventions

• DEVICE

No Results Yet

NCT04419909 | WITHDRAWN | PHASE1

0 participants

Retreatment With CTL019/CTL119

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2026-05-31

Completion:

2026-07-15

Conditions

• Lymphoma, B-Cell

Interventions

• DRUG

No Results Yet

NCT04405401 | ACTIVE_NOT_RECRUITING | PHASE2

68 participants

Stereotactic Ablative Radiotherapy for Oligo-Progressive Non Small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-01-05

Completion:

2026-12-01

Conditions

• Lung Cancer Metastatic

Interventions

• RADIATION
• OTHER

No Results Yet

NCT04404283 | ACTIVE_NOT_RECRUITING | PHASE3

239 participants

Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2020-08-20

Completion:

2026-01-23

Conditions

• Diffuse Large B-cell Lymphoma

Interventions

• DRUG
• OTHER

No Results Yet

NCT04325217 | COMPLETED

586 participants

Post-marketing Surveillance on Long Term Use of Ofev Capsules in Systemic Scleroderma Associated Interstitial Lung Disease (SSc-ILD) in Japan

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-22

Start Date:

2020-05-27

Completion:

2026-07-13

Conditions

• Lung Diseases, Interstitial

Interventions

• DRUG

No Results Yet

NCT04303780 | COMPLETED | PHASE3

345 participants

Study to Compare AMG 510 "Proposed INN Sotorasib" With Docetaxel in Non Small Cell Lung Cancer (NSCLC) (CodeBreak 200).

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2020-06-04

Completion:

2022-08-02

Conditions

• KRAS p, G12c Mutated /Advanced Metastatic NSCLC

Interventions

• DRUG

Results Available

NCT04285086 | ACTIVE_NOT_RECRUITING | PHASE3

174 participants

Ropeginterferon Alfa-2b (P1101) vs. Anagrelide in Essential Thrombocythemia Patients With Hydroxyurea Resistance or Intolerance

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2020-08-25

Completion:

2024-11-12

Conditions

• Essential Thrombocythemia

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT04281485 | ACTIVE_NOT_RECRUITING | PHASE3

114 participants

Study to Evaluate the Safety and Efficacy of PF-06939926 for the Treatment of Duchenne Muscular Dystrophy

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2020-11-05

Completion:

2024-05-15

Conditions

• Duchenne Muscular Dystrophy

Interventions

• GENETIC
• OTHER

Results Available

NCT04272515 | RECRUITING | NA

100 participants

Molecular Characterization for Understanding Biliary Atresia

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-02-07

Completion:

2026-08-07

Conditions

• Biliary Atresia

Interventions

• OTHER

No Results Yet