Clinical Trials

NCT05361174 | RECRUITING | PHASE1/PHASE2

53 participants

A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2022-07-20

Completion:

2027-09-30

Conditions

• Unresectable Melanoma
• Metastatic Melanoma
• Stage III Non-small Cell Lung Cancer
• Stage IV Non-small Cell Lung Cancer

Interventions

• BIOLOGICAL

No Results Yet

NCT05329090 | COMPLETED | PHASE3

75 participants

Evaluation of Glucocorticoids Plus Rituximab in Patients With Newly-Diagnosed or Relapsing IgA Vasculitis

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2022-03-11

Completion:

2026-01-13

Conditions

• IgA Vasculitis

Interventions

• DRUG

No Results Yet

NCT05313243 | RECRUITING | PHASE2

32 participants

Pembrolizumab and Brentuximab Vedotin in Subjects With Relapsed/Refractory T-cell Lymphoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2023-07-10

Completion:

2028-04-30

Conditions

• T-Cell Lymphoma

Interventions

• DRUG

No Results Yet

NCT05303129 | COMPLETED | NA

165 participants

Prognostic Impact of the Neutrophil/Lymphocyte Ratio (NLR) in the Treatment of First-line Metastatic or Locally Advanced Breast Cancer Treated With CDK4/6 Inhibitor.

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2022-05-27

Completion:

2024-12-17

Conditions

• Breast Cancer
• Metastatic Breast Cancer

Interventions

• BIOLOGICAL

Results Available

NCT05283330 | RECRUITING | PHASE1

48 participants

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2022-12-22

Completion:

2027-01-31

Conditions

• Cervical Cancer
• Breast Cancer
• Colon Cancer
• NSCLC
• mCRPC (Metastatic Castration-resistant Prostate Cancer)
• Glioblastoma
• Nonsmall Cell Lung Cancer

Interventions

• DRUG

No Results Yet

NCT05280457 | ACTIVE_NOT_RECRUITING | PHASE2

21 participants

HPV 16-positive and/or HPV 18-positive Recurrent and/or For Patients With Metastatic Head and Neck Cancer to Evaluate GX-188E DNA Vaccination, GX-I7 and Nivolumab Combination Therapy

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2022-04-15

Completion:

2027-01-31

Conditions

• Head and Neck Squamous Cell Carcinoma

Interventions

• DRUG

No Results Yet

NCT05253742 | WITHDRAWN

0 participants

Fetal MRI Acquisition and Sequence Development

Study Type:

OBSERVATIONAL

Last Updated:

2026-06-11

Start Date:

2023-05-31

Completion:

2026-05-31

Conditions

• Pregnancy Related

Interventions

• OTHER

No Results Yet

NCT05241275 | ACTIVE_NOT_RECRUITING | PHASE2

60 participants

Xenon MRI and Progressive ILD

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2022-07-19

Completion:

2025-11-03

Conditions

• Idiopathic Pulmonary Fibrosis
• Progressive Pulmonary Fibrosis

Interventions

• DRUG

No Results Yet

NCT05240716 | COMPLETED | NA

15 participants

Functional Electrical Stimulation on Tibial Nerve in Stroke Patients.

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2022-03-21

Completion:

2026-04-10

Conditions

• Chronic Stroke

Interventions

• OTHER

No Results Yet

NCT05235542 | COMPLETED | PHASE1/PHASE2

128 participants

A Phase Ib/II Study of AK104 and AK117 in Combination With or Without Chemotherapy in Advanced Malignant Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2022-03-12

Completion:

2026-05-09

Conditions

• Advanced Malignant Tumors

Interventions

• DRUG

No Results Yet

NCT05230368 | COMPLETED | PHASE1

9 participants

Evaluation of the Safety and the Tolerability of a Combination of Two HIV Inducers in Patients With Undetectable Viral Load

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2022-12-14

Completion:

2025-12-11

Conditions

• HIV-1-infection, Subtype b

Interventions

• DRUG

No Results Yet

NCT05219929 | COMPLETED | PHASE2

60 participants

Tetracycline Treatment Tolerability Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2022-11-02

Completion:

2026-06-09

Conditions

• Post-Treatment Lyme Disease

Interventions

• DRUG
• OTHER

No Results Yet

NCT05180110 | COMPLETED

79 participants

A Performance Evaluation of the LumiraDx Point of Care CRP Assay

Study Type:

OBSERVATIONAL

Last Updated:

2026-06-11

Start Date:

2021-11-25

Completion:

2022-01-11

Conditions

• Inflammation
• Infections
• Tissue Injury

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT05177536 | ACTIVE_NOT_RECRUITING | PHASE2

40 participants

Iberdomide Maintenance Therapy in Patients With Multiple Myeloma

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2022-06-14

Completion:

2026-01-02

Conditions

• Multiple Myeloma

Interventions

• DRUG

No Results Yet

NCT05171244 | RECRUITING | NA

50 participants

Use of Immersive Virtual Reality to Train the Multisensory Processing Capacities of Children Aged 8 to 16 Years-old With an Autism Spectrum Disorder: Single-center Randomized Pilot Study in Parallel Groups - SEVIRE. (Sensory Virtual Reality)

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2022-03-03

Completion:

2027-10-31

Conditions

• Autism Spectrum Disorder

Interventions

• BEHAVIORAL

No Results Yet

NCT05162391 | COMPLETED | NA

59 participants

Inflammation in Methamphetamine and STIs (IMSTI)

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2022-05-31

Completion:

2026-04-15

Conditions

• Methamphetamine-dependence
• Rectal Gonorrhea
• Rectal Chlamydia

Interventions

• BEHAVIORAL

Results Available

NCT05143983 | COMPLETED | NA

39 participants

Perception of Music and Facial and Vocal Emotions in a Population With and Without Depression

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2022-02-07

Completion:

2023-02-02

Conditions

• Depression

Interventions

• BEHAVIORAL

No Results Yet

NCT05121337 | COMPLETED | NA

180 participants

Groceries for Black Residents of Boston to Stop Hypertension Among Adults Without Treated Hypertension

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2022-09-30

Completion:

2025-06-18

Conditions

• Elevated Blood Pressure
• Hypertension

Interventions

• BEHAVIORAL

No Results Yet

NCT05106777 | ACTIVE_NOT_RECRUITING | PHASE2

47 participants

Surufatinib in Patients With Osteosarcoma and Soft Tissue Sarcoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2021-12-10

Completion:

2025-12-10

Conditions

• Sarcoma

Interventions

• DRUG

No Results Yet

NCT05076760 | RECRUITING | PHASE1

40 participants

MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2022-04-21

Completion:

2027-02-28

Conditions

• Solid Tumor
• Advanced Cancer
• Metastatic Cancer
• Non Small Cell Lung Cancer
• Cutaneous Squamous Cell Carcinoma
• Merkel Cell Carcinoma
• Melanoma
• Pancreatic Cancer
• Triple Negative Breast Cancer
• Head and Neck Cancer

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT05070429 | COMPLETED | NA

339 participants

ACHIEVE Hearing Intervention Follow-Up Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2021-11-12

Completion:

2024-01-10

Conditions

• Hearing Loss
• Aging

Interventions

• OTHER

Results Available

NCT05061238 | ACTIVE_NOT_RECRUITING | NA

15 participants

Impact Of Muscle Vibration On Gait Control

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2021-10-04

Completion:

2027-12-31

Conditions

• Muscle

Interventions

• DEVICE

No Results Yet

NCT05060302 | COMPLETED | NA

191 participants

Prognosis of Right Ventricular Dysfunction Assessed by Speckle Tracking in Postoperative Thoracic Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2021-09-13

Completion:

2023-11-08

Conditions

• Right Ventricle
• Thoracic Surgery

Interventions

• OTHER

No Results Yet

NCT05055063 | RECRUITING | PHASE1

30 participants

A Phase 1 With Extension Cohort, Single Arm, Single Center, Open Label Trial of Belantamab Mafodotin for the Treatment of High-Risk Smoldering Multiple Myeloma

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2022-05-18

Completion:

2027-02-02

Conditions

• Myeloma

Interventions

• DRUG

No Results Yet

NCT05038527 | COMPLETED | NA

120 participants

ABM/P-15 Bone Graft vs Traditional Bone Graft in Adult Spinal Deformity Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2021-10-01

Completion:

2025-02-27

Conditions

• Spine Deformity
• Bone Graft; Complications
• Adverse Events

Interventions

• DEVICE

No Results Yet

NCT05017311 | RECRUITING | PHASE4

400 participants

Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2023-01-20

Completion:

2028-12-31

Conditions

• Major Depressive Disorder

Interventions

• DRUG

No Results Yet

NCT04984811 | TERMINATED | PHASE2

33 participants

NT-I7 in Combination With Atezolizumab in Previously Untreated, PD-L1-expressing, Locally Advanced or Metastatic NSCLC

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2021-11-15

Completion:

2024-08-28

Conditions

• Carcinoma, Non-Small-Cell Lung
• Non-Small Cell Lung Cancer
• Non-Small Cell Lung Carcinoma
• Nonsmall Cell Lung Cancer
• Non Small Cell Lung Cancer

Interventions

• DRUG

Results Available

NCT04959175 | RECRUITING | PHASE1/PHASE2

320 participants

Phase I/II Study to Reduce Post-transplantation Cyclophosphamide Dosing for Older or Unfit Patients Undergoing Bone Marrow Transplantation for Hematologic Malignancies

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2021-09-23

Completion:

2027-04-27

Conditions

• Hematologic Neoplasms

Interventions

• DRUG
• PROCEDURE

No Results Yet

NCT04958798 | COMPLETED | NA

2059 participants

Culturally Centering Medications for Opioid Use Disorder With American Indian and Alaska Native Communities

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2021-12-20

Completion:

2024-12-13

Conditions

• Opioid-use Disorder

Interventions

• BEHAVIORAL

Results Available

NCT04886986 | RECRUITING | PHASE1

42 participants

Phase I Study of 225Ac-J591 Plus 177Lu-PSMA Small Molecule for Progressive Metastatic Castration Resistant Prostate Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2021-06-30

Completion:

2027-12-31

Conditions

• Prostate Cancer

Interventions

• DRUG

No Results Yet

NCT04876742 | RECRUITING | NA

380 participants

Wheat Beer for Prevention of Delirium in Intensive Care Patients

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2023-01-18

Completion:

2028-12-31

Conditions

• ICU Delirium

Interventions

• OTHER

No Results Yet

NCT04815239 | ACTIVE_NOT_RECRUITING | NA

119 participants

Early Intervention for Youth at High Risk for Bipolar Disorder

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2021-09-01

Completion:

2027-04-30

Conditions

• Bipolar Disorder

Interventions

• BEHAVIORAL

No Results Yet

NCT04791449 | RECRUITING | NA

60 participants

Exercise Enhances Wound Healing in Patients With Diabetic Foot Ulcers

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2021-10-10

Completion:

2035-05-31

Conditions

• Diabetic Foot Ulcer

Interventions

• OTHER

No Results Yet

NCT04771520 | RECRUITING | PHASE2

50 participants

Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2021-01-20

Completion:

2026-12-31

Conditions

• Anatomic Stage IV Breast Cancer AJCC v8
• Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
• Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
• Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
• Locally Advanced Malignant Solid Neoplasm
• Locally Advanced Melanoma
• Locally Advanced Primary Malignant Central Nervous System Neoplasm
• Locally Advanced Sarcoma
• Metastatic Malignant Solid Neoplasm
• Metastatic Melanoma
• Metastatic Primary Malignant Central Nervous System Neoplasm
• Metastatic Sarcoma
• Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
• Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
• Pathologic Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
• Prognostic Stage IIIC Breast Cancer AJCC v8
• Prognostic Stage IV Breast Cancer AJCC v8
• Stage IIIC Colorectal Cancer AJCC v8
• Stage IIIC Lung Cancer AJCC v8
• Stage IV Colorectal Cancer AJCC v8
• Stage IV Lung Cancer AJCC v8
• Stage IVA Colorectal Cancer AJCC v8
• Stage IVA Lung Cancer AJCC v8
• Stage IVB Colorectal Cancer AJCC v8
• Stage IVB Lung Cancer AJCC v8
• Stage IVC Colorectal Cancer AJCC v8

Interventions

• DRUG

No Results Yet

NCT04751747 | ACTIVE_NOT_RECRUITING | NA

34 participants

Adaptive Radiation Planning for the Reduction of Radiation-Induced Toxicity in Patients With Stage II-IV Non-small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2021-02-11

Completion:

2026-12-31

Conditions

• Locally Advanced Lung Non-Small Cell Carcinoma
• Metastatic Lung Non-Small Cell Carcinoma
• Stage II Lung Cancer AJCC v8
• Stage IIA Lung Cancer AJCC v8
• Stage IIB Lung Cancer AJCC v8
• Stage III Lung Cancer AJCC v8
• Stage IIIA Lung Cancer AJCC v8
• Stage IIIB Lung Cancer AJCC v8
• Stage IIIC Lung Cancer AJCC v8
• Stage IV Lung Cancer AJCC v8
• Stage IVA Lung Cancer AJCC v8
• Stage IVB Lung Cancer AJCC v8
• Unresectable Lung Non-Small Cell Carcinoma

Interventions

• PROCEDURE
• OTHER

No Results Yet

NCT04745871 | TERMINATED | NA

112 participants

Diagnostic Performance of PSMA PET/CT for Pre-operative Lymph Node Assessment in Intermediate and High-risk Non-metastasic Prostate Cancer (PREOP-PSMA ).

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2021-05-20

Completion:

2025-11-21

Conditions

• Prostate Cancer

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT04737954 | COMPLETED

679 participants

A Performance Evaluation of the LumiraDx Point Of Care D-dimer Assay

Study Type:

OBSERVATIONAL

Last Updated:

2026-06-11

Start Date:

2021-03-18

Completion:

2022-06-30

Conditions

• Deep Vein Thrombosis
• Pulmonary Embolism
• Venous Thromboembolism

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT04732065 | RECRUITING | PHASE1

208 participants

ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2021-08-23

Completion:

2027-05-31

Conditions

• Diffuse Midline Glioma (DMG)
• Glioblastoma
• Recurrent Ependymoma
• Recurrent Malignant Central Nervous System Neoplasm
• Spinal Cord Glioma
• World Health Organization (WHO) Grade III Glioma
• CNS Tumor
• Central Nervous System Tumor

Interventions

• DRUG
• RADIATION
• PROCEDURE

No Results Yet

NCT04728230 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

63 participants

Olaparib and Durvalumab With Carboplatin, Etoposide, and/or Radiation Therapy for the Treatment of Extensive-Stage Small Cell Lung Cancer, PRIO Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2021-01-05

Completion:

2027-12-31

Conditions

• Extensive Stage Lung Small Cell Carcinoma
• Stage IV Lung Cancer AJCC v8
• Stage IVA Lung Cancer AJCC v8
• Stage IVB Lung Cancer AJCC v8

Interventions

• DRUG
• BIOLOGICAL
• RADIATION

No Results Yet

NCT04703907 | COMPLETED | NA

62 participants

Auricular Stimulation for Relief of Stress and Anxiety During COVID-19 Epidemic

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-11

Start Date:

2020-12-03

Completion:

2021-08-30

Conditions

• Stress and Anxiety

Interventions

• OTHER

No Results Yet