Clinical Trials

NCT05076760 | RECRUITING | PHASE1
40 participants

MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors

Study Type:
INTERVENTIONAL
Last Updated:
2026-06-11
Start Date:
2022-04-21
Completion:
2027-02-28
Conditions
  • Solid Tumor
  • Advanced Cancer
  • Metastatic Cancer
  • Non Small Cell Lung Cancer
  • Cutaneous Squamous Cell Carcinoma
  • Merkel Cell Carcinoma
  • Melanoma
  • Pancreatic Cancer
  • Triple Negative Breast Cancer
  • Head and Neck Cancer
Interventions
  • BIOLOGICAL
  • DRUG
No Results Yet
NCT04771520 | RECRUITING | PHASE2
50 participants

Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

Study Type:
INTERVENTIONAL
Last Updated:
2026-06-11
Start Date:
2021-01-20
Completion:
2026-12-31
Conditions
  • Anatomic Stage IV Breast Cancer AJCC v8
  • Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Locally Advanced Malignant Solid Neoplasm
  • Locally Advanced Melanoma
  • Locally Advanced Primary Malignant Central Nervous System Neoplasm
  • Locally Advanced Sarcoma
  • Metastatic Malignant Solid Neoplasm
  • Metastatic Melanoma
  • Metastatic Primary Malignant Central Nervous System Neoplasm
  • Metastatic Sarcoma
  • Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Pathologic Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Prognostic Stage IIIC Breast Cancer AJCC v8
  • Prognostic Stage IV Breast Cancer AJCC v8
  • Stage IIIC Colorectal Cancer AJCC v8
  • Stage IIIC Lung Cancer AJCC v8
  • Stage IV Colorectal Cancer AJCC v8
  • Stage IV Lung Cancer AJCC v8
  • Stage IVA Colorectal Cancer AJCC v8
  • Stage IVA Lung Cancer AJCC v8
  • Stage IVB Colorectal Cancer AJCC v8
  • Stage IVB Lung Cancer AJCC v8
  • Stage IVC Colorectal Cancer AJCC v8
Interventions
  • DRUG
No Results Yet
NCT04751747 | ACTIVE_NOT_RECRUITING | NA
34 participants

Adaptive Radiation Planning for the Reduction of Radiation-Induced Toxicity in Patients With Stage II-IV Non-small Cell Lung Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-06-11
Start Date:
2021-02-11
Completion:
2026-12-31
Conditions
  • Locally Advanced Lung Non-Small Cell Carcinoma
  • Metastatic Lung Non-Small Cell Carcinoma
  • Stage II Lung Cancer AJCC v8
  • Stage IIA Lung Cancer AJCC v8
  • Stage IIB Lung Cancer AJCC v8
  • Stage III Lung Cancer AJCC v8
  • Stage IIIA Lung Cancer AJCC v8
  • Stage IIIB Lung Cancer AJCC v8
  • Stage IIIC Lung Cancer AJCC v8
  • Stage IV Lung Cancer AJCC v8
  • Stage IVA Lung Cancer AJCC v8
  • Stage IVB Lung Cancer AJCC v8
  • Unresectable Lung Non-Small Cell Carcinoma
Interventions
  • PROCEDURE
  • OTHER
No Results Yet
NCT04732065 | RECRUITING | PHASE1
208 participants

ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors

Study Type:
INTERVENTIONAL
Last Updated:
2026-06-11
Start Date:
2021-08-23
Completion:
2027-05-31
Conditions
  • Diffuse Midline Glioma (DMG)
  • Glioblastoma
  • Recurrent Ependymoma
  • Recurrent Malignant Central Nervous System Neoplasm
  • Spinal Cord Glioma
  • World Health Organization (WHO) Grade III Glioma
  • CNS Tumor
  • Central Nervous System Tumor
Interventions
  • DRUG
  • RADIATION
  • PROCEDURE
No Results Yet
NCT04728230 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
63 participants

Olaparib and Durvalumab With Carboplatin, Etoposide, and/or Radiation Therapy for the Treatment of Extensive-Stage Small Cell Lung Cancer, PRIO Trial

Study Type:
INTERVENTIONAL
Last Updated:
2026-06-11
Start Date:
2021-01-05
Completion:
2027-12-31
Conditions
  • Extensive Stage Lung Small Cell Carcinoma
  • Stage IV Lung Cancer AJCC v8
  • Stage IVA Lung Cancer AJCC v8
  • Stage IVB Lung Cancer AJCC v8
Interventions
  • DRUG
  • BIOLOGICAL
  • RADIATION
No Results Yet
NCT04686929 | COMPLETED | PHASE1/PHASE2
29 participants

Abatacept s.c. for aGVHD Prevention in Haplo-HCT

Study Type:
INTERVENTIONAL
Last Updated:
2026-06-11
Start Date:
2021-06-01
Completion:
2023-05-31
Conditions
  • Abatacept
  • Acute-graft-versus-host Disease
  • Haplo-identical HCT
  • Prevention
Interventions
  • DRUG
No Results Yet
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