Clinical Trials

NCT06089954 | ACTIVE_NOT_RECRUITING | NA

2500 participants

Penn Medicine Biobank Return of Results Program

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-10-20

Completion:

2026-07-01

Conditions

• Genetic Disease
• Cancer
• Cardiovascular Diseases

Interventions

• OTHER

No Results Yet

NCT06087445 | COMPLETED | NA

12 participants

A User-friendly, Non-invasive Neuro-orthosis That Restores Volitionally Controlled Grasp Functions for SCI Survivors With Tetraplegia

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-10-31

Completion:

2026-05-11

Conditions

• Cervical Spinal Cord Injury

Interventions

• DEVICE

No Results Yet

NCT06077760 | RECRUITING | PHASE3

868 participants

A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-12-06

Completion:

2030-06-25

Conditions

• Non-small Cell Lung Cancer

Interventions

• BIOLOGICAL
• OTHER

No Results Yet

NCT06064097 | RECRUITING | PHASE2

50 participants

A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2024-06-25

Completion:

2026-12-31

Conditions

• Stage II Nasopharyngeal Carcinoma AJCC v8
• Stage III Nasopharyngeal Carcinoma AJCC v8
• Stage IV Nasopharyngeal Carcinoma AJCC v8

Interventions

• PROCEDURE
• DRUG
• OTHER
• BIOLOGICAL
• RADIATION

No Results Yet

NCT06058377 | RECRUITING | PHASE3

3680 participants

Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-11-27

Completion:

2027-05-31

Conditions

• Anatomic Stage II Breast Cancer AJCC v8
• Anatomic Stage III Breast Cancer AJCC v8
• HER2-Negative Breast Carcinoma
• Hormone Receptor-Positive Breast Carcinoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL
• OTHER

No Results Yet

NCT06052631 | RECRUITING

16 participants

Microneurographic Assessment of Peripheral Nerves in Healthy Volunteers and Individuals With Sensory Dysfunction Caused by Inherited Mutations in the PIEZO2 Gene

Study Type:

OBSERVATIONAL

Last Updated:

2026-05-26

Start Date:

2026-05-28

Completion:

2026-12-31

Conditions

• PIEZO2-Deficiency Syndrome

No Results Yet

NCT06052267 | ACTIVE_NOT_RECRUITING | PHASE3

2772 participants

A Study to Test if a Fixed-Dose Combination of Fluticasone Propionate/Albuterol Sulfate is Effective in Preventing Asthma Exacerbations

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-08-30

Completion:

2026-10-31

Conditions

• Asthma

Interventions

• DRUG

No Results Yet

NCT06051695 | RECRUITING | PHASE1/PHASE2

474 participants

A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2024-04-03

Completion:

2028-06-30

Conditions

• Rectal Cancer
• Cancer
• Solid Tumor, Adult
• Colorectal Cancer
• NSCLC
• Non Small Cell Lung Cancer
• NSCLC, Recurrent
• Non-Small Cell Squamous Lung Cancer
• Pancreas Cancer
• Pancreatic Neoplasm
• Colorectal Adenocarcinoma
• CRC
• Colon Cancer
• Ovarian Cancer
• Ovarian Neoplasms
• Mesothelioma
• Mesothelioma, Malignant
• Ovary Cancer
• Lung Cancer
• MESOM

Interventions

• BIOLOGICAL
• DIAGNOSTIC_TEST

No Results Yet

NCT06051617 | RECRUITING | PHASE3

318 participants

Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-09-07

Completion:

2030-08-31

Conditions

• Primary Biliary Cholangitis

Interventions

• DRUG

No Results Yet

NCT06046222 | ACTIVE_NOT_RECRUITING | PHASE2

45 participants

Trial of Efficacy and Safety of NS-229 Versus Placebo in Patients With Eosinophilic Granulomatosis With Polyangiitis

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-12-20

Completion:

2026-12-31

Conditions

• Eosinophilic Granulomatosis With Polyangiitis
• Churg-Strauss Syndrome

Interventions

• DRUG

No Results Yet

NCT06013995 | COMPLETED | PHASE1

45 participants

A Study to Investigate the Safety, Tolerability, Drug Levels and Drug Effects of BMS-986326 in Adult Participants With Different Forms of Lupus

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-09-21

Completion:

2026-04-14

Conditions

• Lupus

Interventions

• DRUG
• OTHER

No Results Yet

NCT06001918 | RECRUITING | PHASE2/PHASE3

400 participants

Nectero EAST System Clinical Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-10-25

Completion:

2028-06-30

Conditions

• Abdominal Aortic Aneurysm

Interventions

• DRUG

No Results Yet

NCT05989217 | COMPLETED | NA

160 participants

Conservative Therapies in the Treatment of Temporomandibular Disorders

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-03-01

Completion:

2023-12-30

Conditions

• Temporomandibular Joint Disorders
• Temporomandibular Joint Pain
• Splints
• Photobiomodulation

Interventions

• DEVICE
• RADIATION

No Results Yet

NCT05987241 | RECRUITING | PHASE2/PHASE3

992 participants

Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2024-02-02

Completion:

2030-09-02

Conditions

• Muscle Invasive Bladder Urothelial Carcinoma
• Muscle Invasive Renal Pelvis Urothelial Carcinoma
• Muscle Invasive Ureter Urothelial Carcinoma
• Muscle Invasive Urethral Urothelial Carcinoma
• Stage II Bladder Urothelial Carcinoma AJCC v6 and v7
• Stage III Bladder Urothelial Carcinoma AJCC v6 and v7
• Stage IV Bladder Urothelial Carcinoma AJCC v7

Interventions

• PROCEDURE
• OTHER
• BIOLOGICAL

No Results Yet

NCT05977244 | COMPLETED | NA

12 participants

Exploring the Effects of Varying Fat:Carbohydrate Diet Permutations on Gastric Emptying and Metabolic Status Using Human Postprandial Model

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2022-05-21

Completion:

2024-12-24

Conditions

• Postprandial Lipemia
• Postprandial Glycemia
• Gastric Emptying

Interventions

• OTHER

No Results Yet

NCT05970042 | ACTIVE_NOT_RECRUITING | NA

29 participants

Investigating the Effects of the "GameDay Ready" Behavioral Weight Management Program for Black Men Living in the Rural South

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-08-04

Completion:

2026-03-23

Conditions

• Obesity

Interventions

• BEHAVIORAL

No Results Yet

NCT05950438 | RECRUITING

120 participants

Investigating Outcomes of Elective Robotic Transhiatal Esophagectomy

Study Type:

OBSERVATIONAL

Last Updated:

2026-05-26

Start Date:

2023-07-11

Completion:

2028-05-25

Conditions

• Esophagectomy

Interventions

• PROCEDURE

No Results Yet

NCT05948007 | WITHDRAWN | NA

0 participants

The Role of Neurofeedback Training and Pain Management in Post-operative Shoulder Rehabilitation

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-11-01

Completion:

2026-05-21

Conditions

• Pain, Shoulder
• Post Operative Pain

Interventions

• DEVICE
• BEHAVIORAL

No Results Yet

NCT05943535 | RECRUITING | PHASE3

698 participants

Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-10-30

Completion:

2027-11-30

Conditions

• Progressive Pulmonary Fibrosis
• Interstitial Lung Disease

Interventions

• DRUG
• DEVICE

No Results Yet

NCT05943106 | ACTIVE_NOT_RECRUITING | PHASE3

100 participants

BCG in Combination With Durvalumab in Adult BCG-naïve, High-risk NMIBC Participants

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-08-11

Completion:

2025-06-16

Conditions

• Non-Muscle- Invasive Bladder Cancer

Interventions

• BIOLOGICAL

No Results Yet

NCT05939414 | RECRUITING | PHASE3

450 participants

An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2024-03-12

Completion:

2028-04-25

Conditions

• Oligometastatic Prostate Cancer (OMPC)

Interventions

• DRUG

No Results Yet

NCT05925803 | ACTIVE_NOT_RECRUITING | PHASE3

314 participants

Determine Effectiveness of Anifrolumab In SYstemic Sclerosis (DAISY)

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-11-08

Completion:

2027-01-06

Conditions

• Systemic Sclerosis
• Scleroderma

Interventions

• COMBINATION_PRODUCT
• DRUG

No Results Yet

NCT05921487 | ENROLLING_BY_INVITATION | NA

15 participants

Time Restricted Eating to Mitigate Obesity in Veterans With Spinal Cord Injury

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-09-01

Completion:

2026-06-01

Conditions

• Spinal Cord Injury
• Obesity

Interventions

• BEHAVIORAL

No Results Yet

NCT05920330 | RECRUITING | NA

330 participants

Nasal Obstruction and Olfactory Losses

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-01-25

Completion:

2027-07-31

Conditions

• Nasal Obstruction

Interventions

• OTHER

No Results Yet

NCT05901766 | NOT_YET_RECRUITING | PHASE4

600 participants

Effect of Iodine-containing Multiple Micronutrient During Lactation on Infant Neurodevelopment

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2026-05-01

Completion:

2027-10-04

Conditions

• Iodine Deficiency
• Nutrition Poor
• Development, Infant
• Breastfeeding

Interventions

• DIETARY_SUPPLEMENT

No Results Yet

NCT05887700 | RECRUITING

145 participants

Lifetech CeraFlex™ ASD Closure System Post-Market Clinical Follow-Up

Study Type:

OBSERVATIONAL

Last Updated:

2026-05-26

Start Date:

2024-07-09

Completion:

2026-12-30

Conditions

• Atrial Septal Defect

Interventions

• DEVICE

No Results Yet

NCT05874934 | COMPLETED | NA

40 participants

Endoscopic Drainage of Presumed Resectable pCCA Using an Intrahepatic Plastic Stent With Retrieval String

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-03-01

Completion:

2026-05-21

Conditions

• Perihilar Cholangiocarcinoma

Interventions

• DEVICE

No Results Yet

NCT05874141 | COMPLETED | NA

295 participants

Comorbidities in Type 2 Diabetes Mellitus

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-11-15

Completion:

2025-12-30

Conditions

• Type 2 Diabetes

Interventions

• DIAGNOSTIC_TEST
• PROCEDURE

No Results Yet

NCT05864560 | ACTIVE_NOT_RECRUITING

164 participants

Ankura™ AAA, Cuff and AUI Stent Graft System Post-Market Clinical Follow-Up

Study Type:

OBSERVATIONAL

Last Updated:

2026-05-26

Start Date:

2023-09-15

Completion:

2026-08-30

Conditions

• Abdominal Aortic Aneurysm

Interventions

• DEVICE

No Results Yet

NCT05863572 | COMPLETED | NA

179 participants

Strengthening Care in Collaboration With People With Lived Experience of Psychosis in Uganda

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2024-01-16

Completion:

2026-01-13

Conditions

• Psychosis

Interventions

• OTHER

No Results Yet

NCT05834725 | COMPLETED | NA

260 participants

Resilience Coaching for Adolescents With Chronic Musculoskeletal Pain

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-05-08

Completion:

2025-11-02

Conditions

• Pain, Chronic
• Pain Syndrome
• Psychological

Interventions

• BEHAVIORAL
• OTHER

No Results Yet

NCT05828069 | RECRUITING | PHASE2

48 participants

A Study With Tovorafenib (DAY101) as a Treatment Option for Progressive, Relapsed, or Refractory Langerhans Cell Histiocytosis

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2024-03-28

Completion:

2028-09-30

Conditions

• Recurrent Langerhans Cell Histiocytosis
• Refractory Langerhans Cell Histiocytosis

Interventions

• DRUG
• PROCEDURE

No Results Yet

NCT05822141 | RECRUITING | NA

30 participants

Omega-3 Fatty Acids as Regulators of Brown Adipose Tissue During Cold Exposure

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-06-12

Completion:

2026-12-31

Conditions

• Cold Exposure

Interventions

• DIETARY_SUPPLEMENT

No Results Yet

NCT05789173 | RECRUITING | EARLY_PHASE1

60 participants

Interaction of CYP2B6 Genotype and Efavirenz With Methadone and Tizanidine PK

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-10-06

Completion:

2027-04-30

Conditions

• Drug-Drug Interaction

Interventions

• DRUG

No Results Yet

NCT05774275 | RECRUITING | PHASE1/PHASE2

52 participants

The Combination of Radiotherapy, Chemotherapy and Immunotherapy in High-Risk Localized Soft Tissue Sarcoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2022-08-25

Completion:

2027-08-24

Conditions

• High-Risk Localized Soft Tissue Sarcoma

Interventions

• DRUG
• RADIATION

No Results Yet

NCT05773274 | RECRUITING | PHASE2

100 participants

Comparing Retreatment of 177Lu-DOTATATE PRRT Versus the Usual Treatment in Patients With Metastatic Unresectable Gastroenteropancreatic Neuroendocrine Tumors, NET RETREAT Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2024-01-12

Completion:

2029-04-30

Conditions

• Metastatic Digestive System Neuroendocrine Tumor G1
• Metastatic Digestive System Neuroendocrine Tumor G2
• Unresectable Digestive System Neuroendocrine Tumor G1
• Unresectable Digestive System Neuroendocrine Tumor G2

Interventions

• PROCEDURE
• DRUG
• OTHER

No Results Yet

NCT05769153 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

139 participants

Study of AR-14034 in Participants With Neovascular Age-Related Macular Degeneration (nAMD)

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-12-06

Completion:

2027-05-31

Conditions

• Neovascular Age-related Macular Degeneration (nAMD)

Interventions

• DRUG

No Results Yet

NCT05761743 | ACTIVE_NOT_RECRUITING

80 participants

Glycemic Control, Type II Diabetes, Parathyroidectomy

Study Type:

OBSERVATIONAL

Last Updated:

2026-05-26

Start Date:

2023-02-27

Completion:

2025-12-31

Conditions

• Primary Hyperparathyroidism
• Type 2 Diabetes

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT05740241 | COMPLETED

87 participants

Use of New Tools to Estimate the Intensity of Adapted Physical Activity Sessions

Study Type:

OBSERVATIONAL

Last Updated:

2026-05-26

Start Date:

2024-02-05

Completion:

2025-06-23

Conditions

• Ageing

Interventions

• OTHER

No Results Yet

NCT05723562 | ACTIVE_NOT_RECRUITING | PHASE2

154 participants

A Study of Dostarlimab in Untreated dMMR/MSI-H Locally Advanced Rectal Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-05-26

Start Date:

2023-04-03

Completion:

2026-11-02

Conditions

• Neoplasms, Rectal

Interventions

• BIOLOGICAL

No Results Yet